Toxicity, therapeutic applicability, and safe handling of magnetic nanomaterials

Abstract Nanotechnology is a fast-growing field with the broad application of magnetic nanoparticles (MNPs) in different facets of modern human life being a perfect example. MNPs have recently emerged in many industrial technologies and devices related to biomedical, environmental, and clinical disciplines. Such a variety of critical applications of MNPs triggered new important areas of research; this chapter is primarily focused on three main themes: (1) basic characteristics of long-term interaction/behavior between MNPs and biological life, (2) pros and cons of their toxic effects on human cells, and (3) state-of-the-art techniques for safe disposal/recycling of consumed MNPs. Additionally, we highlight the importance of some toxic characteristics of MNPs in cancer treatment through hyperthermia phenomena. We also discussed the importance of MNPs in targeting cancer cells and their application in modern chemotherapy strategies.

[1]  Weihong Tan,et al.  Synthesis and Characterization of Silica-Coated Iron Oxide Nanoparticles in Microemulsion: The Effect of Nonionic Surfactants , 2001 .

[2]  J. Minier,et al.  A new stochastic approach for the simulation of agglomeration between colloidal particles. , 2013, Langmuir : the ACS journal of surfaces and colloids.

[3]  Gareth J.S. Jenkins,et al.  Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION) , 2010, Nano reviews.

[4]  L. Rossi,et al.  Magnetic nanomaterials in catalysis: advanced catalysts for magnetic separation and beyond , 2014 .

[5]  Yue-Wern Huang,et al.  The Toxicity of Nanoparticles Depends on Multiple Molecular and Physicochemical Mechanisms , 2017, International journal of molecular sciences.

[6]  J. Herrera,et al.  Enhanced stability and dechlorination activity of pre-synthesis stabilized nanoscale FePd particles. , 2010, Journal of contaminant hydrology.

[7]  Mary Elizabeth Williams,et al.  Synthesis of Fe Oxide Core/Au Shell Nanoparticles by Iterative Hydroxylamine Seeding , 2004 .

[8]  Guang Yang,et al.  Current state of sludge production, management, treatment and disposal in China. , 2015, Water research.

[9]  M. Nurunnabi,et al.  A photosensitizer-conjugated magnetic iron oxide/gold hybrid nanoparticle as an activatable platform for photodynamic cancer therapy. , 2014, Journal of materials chemistry. B.

[10]  Peter van Gelderen,et al.  Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells , 2001, Nature Biotechnology.

[11]  K. Klabunde,et al.  Unique Chemical Reactivities of Nanocrystalline Metal Oxides toward Hydrogen Sulfide , 2002 .

[12]  Julie W. Fitzpatrick,et al.  Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy , 2005, Particle and Fibre Toxicology.

[13]  James R. Swartz,et al.  The exciting potential of modular nanoparticles for rapid development of highly effective vaccines , 2018 .

[14]  Yun Han,et al.  Effects of natural organic matter on aggregation kinetics of boron nanoparticles in monovalent and divalent electrolytes. , 2010, Journal of colloid and interface science.

[15]  Alberto Carlos Botazzo Delbem,et al.  Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity , 2018, Antibiotics.

[16]  K. Hamad-Schifferli,et al.  Extinction Coefficient of Gold Nanostars. , 2015, The journal of physical chemistry. C, Nanomaterials and interfaces.

[17]  M. Elimelech,et al.  Influence of natural organic matter and ionic composition on the kinetics and structure of hematite colloid aggregation: implications to iron depletion in estuaries. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[18]  S. Kralj,et al.  Magnetic properties of novel superparamagnetic iron oxide nanoclusters and their peculiarity under annealing treatment , 2014 .

[19]  A. Wu,et al.  biomedical applications of magnetic nanoparticles , 2010 .

[20]  A. Pratt Chapter 7 – Environmental Applications of Magnetic Nanoparticles , 2014 .

[21]  M. Ychou,et al.  Assessment of liver metastases from colorectal adenocarcinoma following chemotherapy: SPIO-MRI versus FDG-PET/CT , 2010, La radiologia medica.

[22]  Mohammad Abdollahi,et al.  Toxicity of Nanoparticles and an Overview of Current Experimental Models , 2016, Iranian biomedical journal.

[23]  R. Hong,et al.  Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging , 2008 .

[24]  K. Chen,et al.  Aggregation kinetics of citrate and polyvinylpyrrolidone coated silver nanoparticles in monovalent and divalent electrolyte solutions. , 2011, Environmental science & technology.

[25]  Guangliang Liu,et al.  Dispersion and stability of bare hematite nanoparticles: effect of dispersion tools, nanoparticle concentration, humic acid and ionic strength. , 2012, The Science of the total environment.

[26]  A. Pugazhendhi,et al.  Toxic effects of magnetic nanoparticles on normal cells and organs , 2019, Life sciences.

[27]  R. Castro,et al.  Surface Segregation in SnO2–Fe2O3 Nanopowders and Effects in Mössbauer Spectroscopy , 2005 .

[28]  S. Kalidindi,et al.  Environmental benefits of construction and demolition debris recycling: Evidence from an Indian case study using life cycle assessment , 2020 .

[29]  Tongyang Xu,et al.  Greenhouse Gas Emissions from Landfills: A Review and Bibliometric Analysis , 2019, Sustainability.

[30]  M. Barlaz,et al.  An Assessment of the Dynamic Global Warming Impact Associated with Long-Term Emissions from Landfills. , 2019, Environmental science & technology.

[31]  A. Ricelli,et al.  Functionalized Magnetic Nanoparticles as Catalysts for Enantioselective Henry Reaction , 2019, ACS omega.

[32]  C. Liao,et al.  Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans , 2017, International journal of nanomedicine.

[33]  Wei Yu,et al.  A Review on Nanofluids: Preparation, Stability Mechanisms, and Applications of Ethylene Glycol – Water Based Nanofluids Dispersed with Multi Walled Carbon Nanotubes , 2024, INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT.

[34]  F. Emmerling,et al.  The size distribution of 'gold standard' nanoparticles , 2009, Analytical and bioanalytical chemistry.

[35]  Usha Singh Gaharwar,et al.  Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats , 2019, International journal of nanomedicine.

[36]  Mohammad Reza Zamani Kouhpanji,et al.  A Guideline for Effectively Synthesizing and Characterizing Magnetic Nanoparticles for Advancing Nanobiotechnology: A Review , 2020, Sensors.

[37]  Anubhab Mukherjee,et al.  Recent Trends of the Bio-Inspired Nanoparticles in Cancer Theranostics , 2019, Front. Pharmacol..

[38]  Hui Mao,et al.  Magnetic nanoparticles for precision oncology: theranostic magnetic iron oxide nanoparticles for image-guided and targeted cancer therapy. , 2017, Nanomedicine.

[39]  Nathalie Tufenkji,et al.  Aggregation and deposition of engineered nanomaterials in aquatic environments: role of physicochemical interactions. , 2010, Environmental science & technology.

[40]  Ronnie H. Fang,et al.  Cell Membrane Coating Nanotechnology , 2018, Advanced materials.

[41]  D. Satuła,et al.  Stability of Fe3O4 nanoparticles in various model solutions , 2014 .

[42]  R. Weissleder,et al.  Surface‐Functionalized Nanoparticle Library Yields Probes for Apoptotic Cells , 2004, Chembiochem : a European journal of chemical biology.

[43]  C. Dai,et al.  Heterogeneous Nucleation and Growth of Barium Sulfate at Organic-Water Interfaces: Interplay between Surface Hydrophobicity and Ba(2+) Adsorption. , 2016, Langmuir : the ACS journal of surfaces and colloids.

[44]  Yuan He,et al.  Magnetic nanoparticles based cancer therapy: current status and applications , 2018, Science China Life Sciences.

[45]  Oleg Inshakov,et al.  World market for nanomaterials: structure and trends , 2017 .

[46]  F. Schué,et al.  Terminology for biorelated polymers and applications (IUPAC Recommendations 2012) , 2012 .

[47]  S. Ghoshal,et al.  Systematic comparison of the size, surface characteristics and colloidal stability of zero valent iron nanoparticles pre- and post-grafted with common polymers , 2011 .

[48]  W. Kuschner,et al.  Human pulmonary responses to experimental inhalation of high concentration fine and ultrafine magnesium oxide particles. , 1997, Environmental health perspectives.

[49]  C. Dinu,et al.  Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity , 2018, Scientific Reports.

[50]  Hoik Lee,et al.  Colloidal stability of iron oxide nanoparticles with multivalent polymer surfactants. , 2015, Journal of colloid and interface science.

[51]  Vojtech Adam,et al.  Magnetic Nanoparticles: From Design and Synthesis to Real World Applications , 2017, Nanomaterials.

[52]  C. O'connor,et al.  Recent advances in the liquid-phase syntheses of inorganic nanoparticles. , 2004, Chemical reviews.

[53]  M. Radomski,et al.  Magnetic Nanoparticles in Cancer Theranostics , 2015, Theranostics.

[54]  A. Haes,et al.  What Does Nanoparticle Stability Mean? , 2019, The journal of physical chemistry. C, Nanomaterials and interfaces.

[55]  G. Reyne,et al.  Monitoring the endocytosis of magnetic nanoparticles by cells using permanent micro-flux sources , 2012, Biomedical microdevices.

[56]  P. A. McKeown,et al.  Nanotechnology: International Developments and Emerging Products , 2000 .

[57]  Zhuang Liu,et al.  Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging. , 2016, Nanoscale.

[58]  H. Bienfait,et al.  Depolarization of Cell Membrane Potential during Trans-Plasma Membrane Electron Transfer to Extracellular Electron Acceptors in Iron-Deficient Roots of Phaseolus vulgaris L. , 1984, Plant physiology.

[59]  N. He,et al.  Applications of Magnetic Nanoparticles in Targeted Drug Delivery System. , 2015, Journal of nanoscience and nanotechnology.

[60]  N. He,et al.  Synthesis and characterization of a novel magnetic carrier with its composition of Fe3O4/carbon using hydrothermal reaction , 2006 .

[61]  Ajay Kumar Gupta,et al.  Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. , 2005, Biomaterials.

[62]  Quanguo He,et al.  Sonochemical synthesis, structure and magnetic properties of air-stable Fe3O4/Au nanoparticles , 2007 .

[63]  Zhengguo Song,et al.  Oxidative stress and DNA damage in zebrafish liver due to hydroxyapatite nanoparticles-loaded cadmium. , 2018, Chemosphere.

[64]  A. Haes,et al.  Impacts of pH and Intermolecular Interactions on Surface-Enhanced Raman Scattering Chemical Enhancements , 2018, The Journal of Physical Chemistry C.

[65]  S. Shen,et al.  Magnetic nanoparticle clusters for photothermal therapy with near-infrared irradiation. , 2015, Biomaterials.

[66]  Sang Won Lee,et al.  Easy Synthesis and Magnetic Properties of Iron Oxide Nanoparticles , 2004 .

[67]  Yadong Yin,et al.  Colloidal nanocrystal synthesis and the organic–inorganic interface , 2005, Nature.

[68]  Lingling Wu,et al.  Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus , 2015, Arthritis Research & Therapy.

[69]  Khalid Saeed,et al.  Nanoparticles: Properties, applications and toxicities , 2017, Arabian Journal of Chemistry.

[70]  A. C. Bruno,et al.  Magnetic Fe3O4 nanoparticles coated by natural rubber latex as MRI contrast agent , 2019, Journal of Magnetism and Magnetic Materials.

[71]  G. Jiang,et al.  Distribution, Bioaccumulation, Trophic Transfer, and Influences of CeO2 Nanoparticles in a Constructed Aquatic Food Web. , 2017, Environmental science & technology.

[72]  Xuejun Pan,et al.  Highly stable and covalently functionalized magnetic nanoparticles by polyethyleneimine for Cr(VI) adsorption in aqueous solution , 2015 .

[73]  Zhila Mohajeri Avval,et al.  Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application , 2019, Drug metabolism reviews.

[74]  R. Norwood,et al.  Enhanced magnetism in highly ordered magnetite nanoparticle-filled nanohole arrays. , 2014, Small.

[75]  Meijia Wu,et al.  Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment. , 2017, Molecular and clinical oncology.

[76]  Carlos Rinaldi,et al.  Thermal potentiation of chemotherapy by magnetic nanoparticles. , 2013, Nanomedicine.

[77]  C. Serna,et al.  Yttria-Coated FeCo Magnetic Nanoneedles , 2004 .

[78]  Jianping Wang,et al.  Magnetic nanoparticles in nanomedicine: a review of recent advances , 2018, Nanotechnology.

[79]  S. Djurić,et al.  Silicon in synthesis: stabase adducts - a new primary amine protecting group: alkylation of ethyl glycinate , 1981 .

[80]  T. Korakianitis,et al.  Oxidation and ignition of aluminum nanomaterials. , 2013, Physical chemistry chemical physics : PCCP.

[81]  Guanghai Li,et al.  Fe3O4@SiO2 Core/Shell Nanoparticles: The Silica Coating Regulations with a Single Core for Different Core Sizes and Shell Thicknesses , 2012 .

[82]  H. Karlsson,et al.  Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. , 2008, Chemical research in toxicology.

[83]  Irene M C Lo,et al.  Magnetic nanoparticles: essential factors for sustainable environmental applications. , 2013, Water research.

[84]  A. Arulrajah,et al.  State-Of-The-Art Review of Geosynthetic Clay Liners , 2017 .

[85]  H. Shokrollahi,et al.  Ferrite-based magnetic nanofluids used in hyperthermia applications , 2012 .

[86]  R. Sethi,et al.  Stabilization of highly concentrated suspensions of iron nanoparticles using shear-thinning gels of xanthan gum. , 2009, Water research.

[87]  Richard A. Revia,et al.  Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. , 2016, Materials today.

[88]  Ki-Bum Lee,et al.  Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells. , 2014, Small.

[89]  Navid B. Saleh,et al.  Aggregation and sedimentation of aqueous nanoscale zerovalent iron dispersions. , 2007, Environmental science & technology.

[90]  A. Haes,et al.  Correlating Molecular Surface Coverage and Solution-Phase Nanoparticle Concentration to Surface-Enhanced Raman Scattering Intensities , 2011 .

[91]  T. Pellegrino,et al.  Magnetic properties of iron oxide nanoparticles prepared by seeded-growth route , 2013, Journal of Nanoparticle Research.

[92]  Xiaoguang Meng,et al.  Effects of monovalent and divalent metal cations on the aggregation and suspension of Fe3O4 magnetic nanoparticles in aqueous solution. , 2017, The Science of the total environment.

[93]  S. Rocks,et al.  Advancing the Understanding of Environmental Transformations, Bioavailability and Effects of Nanomaterials, an International US Environmental Protection Agency—UK Environmental Nanoscience Initiative Joint Program , 2018, Journal of environmental protection.

[94]  G. Lowry,et al.  Environmental transformations of silver nanoparticles: impact on stability and toxicity. , 2012, Environmental science & technology.

[95]  Ika Oktavia Wulandari,et al.  Preparation and Characterization of Chitosan-coated Fe3O4 Nanoparticles using Ex-Situ Co-Precipitation Method and Tripolyphosphate/Sulphate as Dual Crosslinkers , 2018 .

[96]  Younghun Kim,et al.  New Paradigm for Nanowastes Treatment , 2012 .

[97]  Catherine C. Berry,et al.  Functionalisation of magnetic nanoparticles for applications in biomedicine , 2003 .

[98]  Navid B. Saleh,et al.  Stabilization of aqueous nanoscale zerovalent iron dispersions by anionic polyelectrolytes: adsorbed anionic polyelectrolyte layer properties and their effect on aggregation and sedimentation , 2008 .

[99]  K. Krishnan,et al.  Magnetic nanoparticles: material engineering and emerging applications in lithography and biomedicine , 2015, Journal of Materials Science.

[100]  Xiangling Gu,et al.  Mussel-Inspired polydopamine coated iron oxide nanoparticles for biomedical application , 2015 .

[101]  Morteza Milani,et al.  Magnetic nanoparticles in cancer diagnosis and treatment: a review , 2017, Artificial cells, nanomedicine, and biotechnology.

[102]  Xiangling Gu,et al.  Synthesis of superparamagnetic iron oxide nanoparticles modified with MPEG-PEI via photochemistry as new MRI contrast agent , 2015 .

[103]  L. Hajba,et al.  The use of magnetic nanoparticles in cancer theranostics: Toward handheld diagnostic devices. , 2016, Biotechnology advances.

[104]  Jelena Kolosnjaj-Tabi,et al.  Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment. , 2016, ACS nano.

[105]  C. Robic,et al.  Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. , 2008, Chemical reviews.

[106]  Victorino Franco,et al.  Magnetocaloric effect: From materials research to refrigeration devices , 2018 .

[107]  Xingzhong Zhao,et al.  Myeloid‐Derived Suppressor Cell Membrane‐Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death , 2018, Advanced Functional Materials.

[108]  B. Evers,et al.  The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity. , 2015, Acta biomaterialia.

[109]  I. Lucet,et al.  Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. , 1996, Journal of microencapsulation.

[110]  U. Panne,et al.  Functionalized magnetic nanoparticles: Synthesis, characterization, catalytic application and assessment of toxicity , 2018, Scientific Reports.