Effect of phosphate on the biosynthesis of nourseothricin by Streptomyces noursei JA 3890b.

The results present evidence for the important role of phosphate-mediated regulation of the nourseothricin biosynthesis by the processes of phosphate limitation and release of phosphate. Also, higher initial concentrations of phosphate were found to have a strong inhibitory effect on the biosynthesis of nourseothricin. It is concluded that the initial phosphate concentration was the primary target for the biometrical optimization of the fermentation medium. The presence of zinc ions neutralized the negative effect of high initial concentrations of phosphate which was also strongly influenced by the regime of sterilization.

[1]  Jörg-Hermann Ozegowski,et al.  Untersuchungen zum stoffwechsel phosphatlimitierter streptomycetenkulturen , 1984 .

[2]  R. Recknagel,et al.  A new biometrical screening method as applied to nutrient optimization in fermentation , 1983 .

[3]  J. Ozegowski,et al.  Sequential processes of phosphate limitation and of phosphate release in streptomycin fermentations. , 1983, Zeitschrift fur allgemeine Mikrobiologie.

[4]  P. Müller,et al.  Parallel regulation of cAMP phosphodiesterase and phosphatase activities in turimycin fermentations. , 1983, Zeitschrift fur allgemeine Mikrobiologie.

[5]  J. Ozegowski,et al.  Regulation of hydrolase formation and phosphate release in turimycin fermentations. , 1983, Zeitschrift fur allgemeine Mikrobiologie.

[6]  W. Effenberger,et al.  Uncoupling of respiration in turimycin fermentations. , 1983, Zeitschrift fur allgemeine Mikrobiologie.

[7]  M. Menner,et al.  Phosphate release in turimycin fermentations. , 1982, Zeitschrift fur allgemeine Mikrobiologie.

[8]  Y. Aharonowitz.  Nitrogen metabolite regulation of antibiotic biosynthesis. , 1980, Annual review of microbiology.

[9]  J F Martin,et al.  Control of antibiotic biosynthesis. , 1980, Microbiological reviews.

[10]  J. Martín.  Control of antibiotic synthesis by phosphate , 1977 .

[11]  W. T. Edmondson.  VOLLENWEIDER, R. A. 1968. Water management research. Scientific fundamentals of the eutrophication of lakes and flowing waters with particular reference to nitrogen and phosphorus as factors in eutrophication. Organization for Economic Co-operation and De , 1970 .

[12]  R. Vollenweider,et al.  Scientific fundamentals of the eutrophication of lakes and flowing waters , 1968 .

[13]  H. Thrum,et al.  Nourseothricin A und B, zwei neue antibakterielle Antibiotica einer Streptomyces-noursei- Variante , 1963 .