Central nervous system complications in hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis is a rare disease, affecting multiple systems. Central nervous system involvement is very important because of the effect on the prognosis. Arising neurological symptoms as a result of this involvement are included in some publications, but the number of publications related to their frequency, characteristics, and relations with morbidity and mortality is rare. In this article, we wanted to attract attention to the picture of the central nervous system involvement as a result of hemophagocytic lymphohistiocytosis.

[1]  S. Esposito,et al.  Debate around infection-dependent hemophagocytic syndrome in paediatrics , 2013, BMC Infectious Diseases.

[2]  H. Im,et al.  Central nervous system (CNS) involvement is a critical prognostic factor for hemophagocytic lymphohistiocytosis , 2012, The Korean journal of hematology.

[3]  Navneet Singh,et al.  Diagnosing and treating hemophagocytic lymphohistiocytosis in the tropics: systematic review from the Indian subcontinent. , 2012, Acta medica academica.

[4]  Sebastian F N Bode,et al.  Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis , 2012, Arthritis Research & Therapy.

[5]  N. Mahlaoui,et al.  CNS involvement at the onset of primary hemophagocytic lymphohistiocytosis , 2012, Neurology.

[6]  S. Ehl,et al.  A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes. , 2012, Blood.

[7]  E. Onelöv,et al.  Risk factors for early death in children with haemophagocytic lymphohistiocytosis , 2012, Acta paediatrica.

[8]  G. Janka,et al.  Familial and acquired hemophagocytic lymphohistiocytosis. , 2012, Annual review of medicine.

[9]  A. Filipovich,et al.  How I treat hemophagocytic lymphohistiocytosis. , 2011, Blood.

[10]  G. Koretzky,et al.  Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. , 2011, The Journal of clinical investigation.

[11]  Yongmin Tang,et al.  Advances in Hemophagocytic Lymphohistiocytosis: Pathogenesis, Early Diagnosis/Differential Diagnosis, and Treatment , 2011, TheScientificWorldJournal.

[12]  K. Gilmour,et al.  Familial haemophagocytic lymphohistiocytosis: advances in the genetic basis, diagnosis and management , 2011, Clinical and experimental immunology.

[13]  A. Ramanan,et al.  Profile of hemophagocytic lymphohistiocytosis in children in a tertiary care hospital in India , 2011, Indian pediatrics.

[14]  W. Al-Herz,et al.  Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2. , 2010, Blood.

[15]  A. Fischer,et al.  Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules , 2010, Nature Reviews Immunology.

[16]  J. Henter,et al.  Frequency and development of CNS involvement in Chinese children with hemophagocytic lymphohistiocytosis , 2010, Pediatric blood & cancer.

[17]  K. McClain,et al.  Hemophagocytic lymphohistiocytosis in Texas: Observations on ethnicity and race , 2010, Pediatric blood & cancer.

[18]  S. Gupta,et al.  Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy , 2010, Expert review of clinical immunology.

[19]  S. Ehl,et al.  Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. , 2009, American journal of human genetics.

[20]  G. Janka,et al.  Hemophagocytic Lymphohistiocytosis: When the Immune System Runs Amok , 2009, Klinische Padiatrie.

[21]  U. Blank,et al.  Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. , 2008, Biochimica et biophysica acta.

[22]  M. Abdelhaleem,et al.  The role of hemophagocytosis in bone marrow aspirates in the diagnosis of hemophagocytic lymphohistiocytosis , 2008, Pediatric blood & cancer.

[23]  H. Goo,et al.  A spectrum of neuroradiological findings in children with haemophagocytic lymphohistiocytosis , 2007, Pediatric Radiology.

[24]  A. Ramanan,et al.  The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis. , 2007, Arthritis and rheumatism.

[25]  G. Janka Hemophagocytic syndromes. , 2007, Blood reviews.

[26]  D. Rigante,et al.  Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis , 2007, Rheumatology International.

[27]  P. Courville,et al.  Role of TLR9 in Anti-Nucleosome and Anti-DNA Antibody Production in lpr Mutation-Induced Murine Lupus1 , 2006, The Journal of Immunology.

[28]  S. Wilkerson,et al.  Fulminant Neonatal Liver Failure in Siblings: Probable Congenital Hemophagocytic Lymphohistiocytosis , 2006, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[29]  H. Mitsuya,et al.  PERIPHERAL HEMOPHAGOCYTOSIS: AN EARLY INDICATOR OF ADVANCED SYSTEMIC INFLAMMATORY RESPONSE SYNDROME/HEMOPHAGOCYTIC SYNDROME , 2006, Shock.

[30]  A. Fischer,et al.  Progressive neurologic dysfunctions 20 years after allogeneic bone marrow transplantation for Chediak-Higashi syndrome. , 2005, Blood.

[31]  A. Fischer,et al.  Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity. , 2005, Blood.

[32]  H. Hennies,et al.  Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. , 2005, Human molecular genetics.

[33]  J. Cohen,et al.  Perforin and lymphohistiocytic proliferative disorders , 2005, British journal of haematology.

[34]  A. Fischer,et al.  Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis , 2005, Immunological reviews.

[35]  M. Kurrer,et al.  Soluble hemoglobin–haptoglobin scavenger receptor CD163 as a lineage‐specific marker in the reactive hemophagocytic syndrome , 2005, European journal of haematology.

[36]  E. Schneider,et al.  Modern management of children with haemophagocytic lymphohistiocytosis , 2004, British journal of haematology.

[37]  A. Fischer,et al.  Defective cytotoxic granule-mediated cell death pathway impairs T lymphocyte homeostasis , 2003, Current opinion in rheumatology.

[38]  K. McClain,et al.  Hemophagocytic lymphohistiocytosis masquerading as child abuse: presentation of three cases and review of central nervous system findings in hemophagocytic lymphohistiocytosis. , 2003, Pediatrics.

[39]  N. Fitzgerald,et al.  Imaging characteristics of hemophagocytic lymphohistiocytosis , 2003, Pediatric Radiology.

[40]  S. Kaplan,et al.  Hemophagocytic syndrome in children: an important diagnostic consideration in fever of unknown origin. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[41]  M. Çetin,et al.  Primary Hemophagocytic Lymphohistiocytosis in Turkish Children , 2003, Pediatric hematology and oncology.

[42]  Schneider,et al.  Hemophagocytic Lymphohistiocytosis (HLH) is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer cell induced apoptosis , 2002 .

[43]  M. Carcao,et al.  Adverse Outcomes in Primary Hemophagocytic Lymphohistiocytosis , 2002, Journal of pediatric hematology/oncology.

[44]  R. Clementi,et al.  Adult onset and atypical presentation of hemophagocytic lymphohistiocytosis in siblings carrying PRF1 mutations. , 2002, Blood.

[45]  A. Morimoto,et al.  Recent developments in the management of haemophagocytic lymphohistiocytosis , 2001, Expert opinion on pharmacotherapy.

[46]  D. Schwabe,et al.  Acute encephalopathy as a primary manifestation of haemophagocytic lymphohistiocytosis. , 2001, Developmental medicine and child neurology.

[47]  D. Fisman Hemophagocytic syndromes and infection. , 2000, Emerging infectious diseases.

[48]  J. Lacroix,et al.  Reactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndrome , 2000, Critical care medicine.

[49]  A. Fischer,et al.  Perforin gene defects in familial hemophagocytic lymphohistiocytosis. , 1999, Science.

[50]  大杉 夕子 Cytokine Production Regulating Th1 and Th2 Cytokines in Hemophagocytic Lymphohistiocytosis , 1998 .

[51]  J. Henter,et al.  Neuropathologic findings and neurologic symptoms in twenty-three children with hemophagocytic lymphohistiocytosis. , 1997, The Journal of pediatrics.

[52]  A. Fischer,et al.  Frequency and severity of central nervous system lesions in hemophagocytic lymphohistiocytosis. , 1997, Blood.

[53]  A. Fischer,et al.  Hemophagocytic lymphohistiocytosis. Report of 122 children from the International Registry. FHL Study Group of the Histiocyte Society. , 1996, Leukemia.

[54]  Y. Tsunematsu,et al.  Soluble interleukin-2 receptor: a useful prognostic factor for patients with hemophagocytic lymphohistiocytosis. , 1995, Blood.

[55]  G. Mieli-Vergani,et al.  Haemophagocytic lymphohistiocytosis: experience at two U.K. centres , 1994, British journal of haematology.

[56]  J. Andersson,et al.  Familial hemophagocytic lymphohistiocytosis and viral infections , 1993, Acta paediatrica.

[57]  J. Chan,et al.  Reactive hemophagocytic syndrome--a clinicopathologic study of 40 patients in an Oriental population. , 1992, The American journal of medicine.