Electrical behaviour of the motoneurone membrane during intracellularly applied current steps.

The electrical properties of the motoneurone membrane have so far been investigated by many workers by the use of intracellular application of current steps (Coombs, Eccles & Fatt, 1955a; Araki & Otani, 1955; Frank & Fuortes, 1956; Coombs, Curtis & Eccles, 1959). The changes in transmembrane potential thus produced have been interpreted on the basis of the conventional capacitance-resistance model of the membrane. However, Araki, Ito & Oshima (1962) have recently noticed a rather peculiar behaviour of the motoneurone membrane of the cat; on application of current steps, the potential change reaches a maximum at about 15 msec after the onset of current and thereafter declines gradually to a steady level, stabilizing within about 100 msec. After the current ceases, the potential undershoots the original level and recovers thereto with a time course similar to the decline of the overshoot. This paper gives an account of a systematic investigation of these overand undershoots, and in the discussion it will be found necessary to develop new concepts with respect to the electrical properties of the motoneurone membrane.

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