Efeitos da metadona ou do neostigmine, associados à lidocaína administrados pela via epidural em cães (Effects of methadone or neostigmine in combination with lidocaine for epidural anesthesia in dogs)

Six mature mongrel dogs of both genders, weighing 13.3±3.4kg (mean±SD) were used in the present research. Thirty minutes after premedication with intravenous acepromazine (0.1mg/kg, IV), dogs were randomly assigned to receive epidural administration of one of following three treatments: 2% lidocaine 0.25ml/kg (control), or neostigmine 0.01mg/kg plus lidocaine (NEO), or methadone 0.3mg/kg plus lidocaine (MET). All dogs received all treatments in a cross-over design with at least one-week interval. Heart rate (HR), respiratory rate (RR), systolic arterial pressure (SAP), time to loss of pedal withdrawal reflex, duration of epidural anesthesia, and cranial spread of epidural anesthesia were evaluated for 90 minutes. No differences among treatments in HR, RR, SAP, duration of anesthesia, and time to loss of pedal withdrawal reflex were found. In MET, HR decreased from 30 to 90 minutes compared to baseline and there was a higher cranial spread of epidural anesthesia than in controls and NEO animals. Neostigmine or methadone did not prolong epidural anesthesia with lidocaine in dogs. Methadone, but not neostigmine, appeared to result in more cranial spread of epidural anesthesia with lidocaine.

[1]  M. Mosing,et al.  A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs. , 2006, Veterinary anaesthesia and analgesia.

[2]  Hirokazu Saito,et al.  Postoperative analgesic effect of epidural neostigmine and plasma cortisol and IL-6 responses. , 2004, Journal of clinical anesthesia.

[3]  S. P. L. Luna,et al.  Efeitos cardiorrespiratório e analgésico da clonidina, xilazina, butorfanol, buprenorfina e tramadol, associados a lidocaína, da anestesia epidural de cães , 2004 .

[4]  J. Eisenach,et al.  Epidural Neostigmine Produces Analgesia but Also Sedation in Women after Cesarean Delivery , 2004, Anesthesiology.

[5]  C. Waldner,et al.  An evaluation of the analgesic effects of meloxicam in addition to epidural morphine/mepivacaine in dogs undergoing cranial cruciate ligament repair. , 2003, The Canadian veterinary journal = La revue veterinaire canadienne.

[6]  P. Gambús,et al.  [Postoperative patient-controlled analgesia is more effective with epidural methadone than with intravenous methadone in thoracic surgery]. , 2003, Revista espanola de anestesiologia y reanimacion.

[7]  M. Mosing,et al.  A comparison of the analgesic effects of caudal epidural methadone and lidocaine in the horse. , 2003, Veterinary anaesthesia and analgesia.

[8]  G. Lauretti,et al.  Epidural Morphine and Neostigmine for Postoperative Analgesia After Orthopedic Surgery , 2002, Anesthesia and analgesia.

[9]  P. Pibarot,et al.  Results of preemptive epidural administration of morphine with or without bupivacaine in dogs and cats undergoing surgery: 265 cases (1997-1999). , 2002, Journal of the American Veterinary Medical Association.

[10]  N. Oleskovicz,et al.  Injeção epidural de morfina ou cetamina em cães: avaliação do efeito analgésico pelo emprego de filamentos de von Frey , 2002 .

[11]  R. D’angelo,et al.  Neostigmine Combined with Bupivacaine, Clonidine, and Sufentanil for Spinal Labor Analgesia , 2001, Anesthesia and analgesia.

[12]  Y. Shir,et al.  Methadone is safe for treating hospitalized patients with severe pain , 2001, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[13]  N. Göğüş,et al.  Comparison of postoperative analgesic effects of preemptively used epidural ketamine and neostigmine. , 2000, Journal of clinical anesthesia.

[14]  M. Nakayama,et al.  Analgesic effect of epidural neostigmine after abdominal hysterectomy. , 2000, Journal of clinical anesthesia.

[15]  M. M. Glowaski,et al.  Epidural analgesia in veterinary critical care. , 2000, Clinical techniques in small animal practice.

[16]  M. Owen,et al.  Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia. , 2000, Anesthesiology.

[17]  G. Lauretti,et al.  Study of three different doses of epidural neostigmine coadministered with lidocaine for postoperative analgesia. , 1999, Anesthesiology.

[18]  E. Liu,et al.  Side‐effects of epidural infusions of opioid bupivacaine mixtures , 1998, Anaesthesia.

[19]  M. P. Prieto-Alvarez,et al.  [Comparative study of postoperative analgesia with methadone and fentanyl in continuous peridural perfusion]. , 1997, Revista espanola de anestesiologia y reanimacion.

[20]  J. Martínez-Lage,et al.  [Postoperative analgesia with epidural methadone in patients operated for hernia of the lumbar disc]. , 1997, Revista espanola de anestesiologia y reanimacion.

[21]  J. Eisenach,et al.  Postoperative Analgesia from Intrathecal Neostigmine in Sheep , 1995, Anesthesia and analgesia.

[22]  D. Dutton,et al.  Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section , 1993 .

[23]  T. Yaksh,et al.  The antinociceptive effects of epidural opiates in the cat: Studies on the pharmacology and the effects of lipophilicity in spinal analgesia , 1982, Pain.

[24]  D. A. Pybus,et al.  Comparison of four narcotic analgesics for extradural analgesia. , 1982, British journal of anaesthesia.

[25]  L. Hall.  Chapter 10 – General principles of local analgesia , 2001 .