Spinal Cord Injury Repair in a Rat Model via a Nanofibrous Scaffold Loaded with Illicium Verum Extract: An In Vitro and In Vivo Study

In the current study, illicium verum extract (IVE) was loaded into polycaprolacton/collagen nanofibrous scaffolds using electrospinningmethod. The produced membranes were characterized In Vitro. Spinal cord injury repair was evaluated in a rat model. In Vitro studies showed that IVE-loaded polycaprolacton/collagen scaffolds were fibrous and prevented cellular death in oxidative stress conditions. In Vivo study showed that the developed scaffolds promoted locomotor function after 8 weeks of treatment.

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