The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles

[1]  L. Fradkin,et al.  Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons , 2018, Cell.

[2]  J. Briggs,et al.  The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer , 2018, Cell.

[3]  K. Hayworth,et al.  Enhanced FIB-SEM systems for large-volume 3D imaging , 2017, eLife.

[4]  Thomas Burger,et al.  DAPAR & ProStaR: software to perform statistical analyses in quantitative discovery proteomics , 2016, Bioinform..

[5]  A. Nimmerjahn,et al.  TAM receptors regulate multiple features of microglial physiology , 2016, Nature.

[6]  F. Wendler,et al.  Extracellular vesicles round off communication in the nervous system , 2016, Nature Reviews Neuroscience.

[7]  Brett J. Graham,et al.  Anatomy and function of an excitatory network in the visual cortex , 2016, Nature.

[8]  C. Théry,et al.  Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes , 2016, Proceedings of the National Academy of Sciences.

[9]  S. Mayor,et al.  Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion , 2015, Molecular biology of the cell.

[10]  Jennifer Luebke,et al.  Depletion of microglia and inhibition of exosome synthesis halt tau propagation , 2015, Nature Neuroscience.

[11]  James Briscoe,et al.  Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms , 2015, Nature Communications.

[12]  Maria K. Lehtinen,et al.  Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production , 2015, The Journal of Neuroscience.

[13]  G. Raposo,et al.  Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties , 2014, Scientific Reports.

[14]  F. Wendler,et al.  The ESCRT machinery regulates the secretion and long-range activity of Hedgehog , 2014, Nature.

[15]  David M Feliciano,et al.  Cerebrospinal Fluid Extracellular Vesicles Undergo Age Dependent Declines and Contain Known and Novel Non-coding RNAs , 2014, PloS one.

[16]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[17]  Chad A. Cowan,et al.  Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. , 2014, Cell stem cell.

[18]  C. Teunissen,et al.  Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. , 2014, Journal of proteomics.

[19]  Marco Y. Hein,et al.  Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ * , 2014, Molecular & Cellular Proteomics.

[20]  Christine Carapito,et al.  MSDA, a proteomics software suite for in‐depth Mass Spectrometry Data Analysis using grid computing , 2014, Proteomics.

[21]  Andrew F. Hill,et al.  Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles , 2014, Journal of extracellular vesicles.

[22]  Clotilde Théry,et al.  Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles , 2013, Journal of Cell Science.

[23]  J. D. Macklis,et al.  Molecular logic of neocortical projection neuron specification, development and diversity , 2013, Nature Reviews Neuroscience.

[24]  Nicole H. Wilson,et al.  Sonic Hedgehog Regulates Its Own Receptor on Postcrossing Commissural Axons in a Glypican1-Dependent Manner , 2013, Neuron.

[25]  Aiman S Saab,et al.  Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication , 2013, PLoS biology.

[26]  W. Sundquist,et al.  Membrane fission reactions of the mammalian ESCRT pathway. , 2013, Annual review of biochemistry.

[27]  Cole Trapnell,et al.  TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions , 2013, Genome Biology.

[28]  V. Budnik,et al.  Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release , 2013, Neuron.

[29]  Athar N. Malik,et al.  CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development , 2012, Nature Genetics.

[30]  Ylva Ivarsson,et al.  Syndecan–syntenin–ALIX regulates the biogenesis of exosomes , 2012, Nature Cell Biology.

[31]  Jeremy G. Carlton,et al.  ESCRT-III Governs the Aurora B–Mediated Abscission Checkpoint Through CHMP4C , 2012, Science.

[32]  Anatol C. Kreitzer,et al.  Sonic Hedgehog Expression in Corticofugal Projection Neurons Directs Cortical Microcircuit Formation , 2012, Neuron.

[33]  J. Leszyk,et al.  Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons* , 2012, The Journal of Biological Chemistry.

[34]  E. Clementi,et al.  Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism , 2012, The EMBO journal.

[35]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[36]  C. Théry,et al.  Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation , 2012, Journal of extracellular vesicles.

[37]  S. Mackem,et al.  Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[38]  Mark T. Handley,et al.  Loss-of-function mutations in RAB18 cause Warburg micro syndrome. , 2011, American journal of human genetics.

[39]  G. Lachenal,et al.  Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity , 2011, Molecular and Cellular Neuroscience.

[40]  C. Walsh,et al.  Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors , 2010, Development.

[41]  S. Dymecki,et al.  Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. , 2010, Developmental biology.

[42]  Bulent Ataman,et al.  Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless , 2009, Cell.

[43]  R. Pepperkok,et al.  Rab18 and Rab43 have key roles in ER-Golgi trafficking , 2008, Journal of Cell Science.

[44]  A. McMahon,et al.  Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning , 2008, Development.

[45]  S. Young,et al.  ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration , 2007, Current Biology.

[46]  M. Greenberg,et al.  Polarized Signaling Endosomes Coordinate BDNF-Induced Chemotaxis of Cerebellar Precursors , 2007, Neuron.

[47]  M. Malagón,et al.  Rab18 Inhibits Secretory Activity in Neuroendocrine Cells by Interacting with Secretory Granules , 2007, Traffic.

[48]  C. Chiang,et al.  Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord , 2007, Development.

[49]  G. Fishell,et al.  Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development , 2006, Nature Reviews Neuroscience.

[50]  H. Stenmark,et al.  Endosomal and non-endosomal functions of ESCRT proteins. , 2006, Trends in cell biology.

[51]  A. Joyner,et al.  The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation , 2006, Development.

[52]  D. Westaway,et al.  TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity , 2006, Nature.

[53]  C. Futter,et al.  EGF stimulates annexin 1‐dependent inward vesiculation in a multivesicular endosome subpopulation , 2006, The EMBO journal.

[54]  N. Hirokawa,et al.  FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination , 2005, Nature.

[55]  Suzanne Eaton,et al.  Lipoprotein particles are required for Hedgehog and Wingless signalling , 2005, Nature.

[56]  Paola Arlotta,et al.  Neuronal Subtype-Specific Genes that Control Corticospinal Motor Neuron Development In Vivo , 2005, Neuron.

[57]  A. Joyner,et al.  Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development , 2004, Development.

[58]  G. Raposo,et al.  Exosomes: endosomal-derived vesicles shipping extracellular messages. , 2004, Current opinion in cell biology.

[59]  A. McMahon,et al.  The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance , 2003, Cell.

[60]  J. Slot,et al.  Immunoelectron Microscopic Localization of Cholesterol Using Biotinylated and Non-cytolytic Perfringolysin O , 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[61]  G. Raposo,et al.  Intestinal epithelial cells secrete exosome-like vesicles. , 2001, Gastroenterology.

[62]  S. Hollenberg,et al.  CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. , 2001, Journal of cell science.

[63]  Xin Zeng,et al.  A freely diffusible form of Sonic hedgehog mediates long-range signalling , 2001, Nature.

[64]  A. Ruiz i Altaba,et al.  Sonic hedgehog regulates the growth and patterning of the cerebellum. , 1999, Development.

[65]  M. Scott,et al.  Altered neural cell fates and medulloblastoma in mouse patched mutants. , 1997, Science.

[66]  J. Vandekerckhove,et al.  Tmp21 and p24A, Two Type I Proteins Enriched in Pancreatic Microsomal Membranes, Are Members of a Protein Family Involved in Vesicular Trafficking* , 1996, The Journal of Biological Chemistry.

[67]  T. Jessell,et al.  Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis , 1995, Cell.

[68]  R. Espinosa,et al.  axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase , 1991, Molecular and cellular biology.

[69]  Hollis G. Potter,et al.  Author Manuscript , 2013 .

[70]  P. S. St George-Hyslop,et al.  TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. , 2006, Nature.

[71]  Conrad C. Huang,et al.  BayGenomics: a resource of insertional mutations in mouse embryonic stem cells , 2003, Nucleic Acids Res..

[72]  M. Scott,et al.  Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog , 1999, Neuron.