Accuracy of anthropometric measurements in predicting symptomatic SGA and LGA neonates

Mid‐arm circumference, mid‐arm circumference/head circumference ratio, ponderal index and skinfold thickness at five sites (biceps, triceps, quadriceps, subscapular and flank) were measured in 91 small‐for‐gestational‐age (SGA) and 101 large‐for‐gestational‐age (LGA) neonates to investigate their accuracy in identifying neonates at high risk of complications resulting from disturbed intrauterine growth. Thirty‐one of 91 SGA and 19 of 101 LGA neonates who developed hypoglycaemia and/or polycythaemia were regarded as symptomatic. Mean values of all of the anthropometric parameters differed significantly between symptomatic and asymptomatic SGA or LGA neonates. The quadriceps skinfold thickness was the most sensitive index in predicting symptomatic SGA and LGA neonates (sensitivity 0.93 and 0.95, respectively). The mid‐arm circumference was also a very sensitive index in predicting symptomatic SGA neonates (sensitivity 0.94) but its specificity was extremely low (0.20). The rest of the parameters showed lower sensitivity than quadriceps skinfold thickness associated with similarly low specificity and validity. The findings of this study indicate that the quadriceps skinfold thickness is the most reliable index for use as a screening test for clinical evaluation of SGA and LGA neonates who are likely to develop complications as a result of disturbed intrauterine nutrition.

[1]  H. Laborit,et al.  Possible involvement of a gamma‐hydroxybutyric acid receptor in startle disease , 1994, Acta paediatrica.

[2]  H. Betz,et al.  Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA. , 1993, Science.

[3]  J. Jaeken,et al.  Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease , 1992, The Lancet.

[4]  D. Gozal,et al.  Anthropometric measurements in a newborn population in west Africa: a reliable and simple tool for the identification of infants at risk for early postnatal morbidity. , 1991, The Journal of pediatrics.

[5]  M. Kramer,et al.  Impact of intrauterine growth retardation and body proportionality on fetal and neonatal outcome. , 1990, Pediatrics.

[6]  M. Georgieff,et al.  A Comparison of the Mid‐Arm Circumference/Head Circumference Ratio and Ponderal Index for the Evaluation of Newborn Infants after Abnormal Intrauterine Growth , 1988, Acta paediatrica Scandinavica.

[7]  M. Georgieff,et al.  Mid-arm circumference and mid-arm/head circumference ratios: standard curves for anthropometric assessment of neonatal nutritional status. , 1986, The Journal of pediatrics.

[8]  M. Georgieff,et al.  Mid-arm circumference/head circumference ratios for identification of symptomatic LGA, AGA, and SGA newborn infants. , 1986, The Journal of pediatrics.

[9]  M. Georgieff,et al.  Nutritional assessment of the neonate. , 1986, Clinics in perinatology.

[10]  G. Farmer,et al.  Neonatal skinfold thickness. Measurement and interpretation at or near term. , 1985, Archives of disease in childhood.

[11]  J. Excler,et al.  Anthropometric assessment of nutritional status in newborn infants. Discriminative value of mid arm circumference and of skinfold thickness. , 1985, Early human development.

[12]  Y. Vaucher,et al.  Skinfold thickness in North American infants 24-41 weeks gestation. , 1984, Human biology.

[13]  A. Sacco The Biological Basis of Reproductive and Developmental Medicine , 1984 .

[14]  G. Enzi,et al.  Intrauterine growth and adipose tissue development. , 1981, The American journal of clinical nutrition.

[15]  J. Ballard,et al.  A simplified score for assessment of fetal maturation of newly born infants. , 1979, The Journal of pediatrics.

[16]  R. J. Parsons,et al.  Skinfold Thickness as an Indicator of Neonatal Hypoglycaemia in Infants with Birthweights over 2500g , 1977, Developmental medicine and child neurology.

[17]  T. Mckeown,et al.  Influences on fetal growth. , 1976, Journal of reproduction and fertility.

[18]  A R Feinstein,et al.  XXXI. On the sensitivity, specificity, and discrimination of diagnostic tests , 1975, Clinical pharmacology and therapeutics.

[19]  H. C. Miller,et al.  Diagnosis of impaired fetal growth in newborn infants. , 1971, Pediatrics.

[20]  L. Lubchenco,et al.  Incidence of hypoglycemia in newborn infants classified by birth weight and gestational age. , 1971, Pediatrics.

[21]  K. Kelts,et al.  Genetic and Radiation Hybrid Mapping of the Hyperekplexia , 2006 .

[22]  R. Ridout,et al.  Neonatal Nutrition and Metabolism: Nutritional assessment of the neonate , 2006 .

[23]  J. Khoury,et al.  Diabetic fetal macrosomia: significance of disproportionate growth. , 1993, The Journal of pediatrics.

[24]  G. Wagner,et al.  Measurements of nutritional status of newborn infants. , 1967, Biologia neonatorum. Neo-natal studies.