Inimical Effects of Sodium Fluoride on Ovarian Weight and Relative Tissue Weight Index of Adult Albino Rats

Objective: To determine the impacts of sodium fluoride on ovarian weight and relative tissue weight index (RTWI) of adult Wistar albino rats. Study Design: Comparative study. Place and Duration of Study: This experimental study was performed at the Department of Anatomy, at Shaikh Zayed Postgraduate Medical Institute, Lahore from 25th November to 24th December 2016. Materials and Methods: Forty-four adult female albino Wistar rats were selected randomly for this study. They were segregated into 4 groups, each comprised of eleven rats. Group A was control, group B was low dose experimental, group C was medium dose experimental and group D was high dose experimental. The control group received distilled water whereas low, medium and high dose experimental groups received 100mg/L, 200mg/L and 300mg/L sodium fluoride solution respectively. The animals were weighed before and after experiment. At 31st and 32nd day, dissection was done, ovaries were removed and evaluated for ovarian tissue weight and RTWI. Results: The mean weight and RTWI of paired ovaries among the experimental groups were decreased. The differences among groups were statistically significant. Conclusion: The present study confirms that sodium fluoride has detrimental dose dependent effects on ovarian weight and RTWI of adult albino rats.

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