Photoplethysmography (PPG) is a non-invasive technique that employs near infrared light to estimate periodic oscillations in blood volume within arteries caused by the pulse pressure wave. Importantly, combined Electrocardiography (ECG) and PPG can be employed to quantify arterial stiffness. The capabilities of a home-made multi-channel PPG-ECG device (7 PPG probes, 4 ECG derivations) to evaluate arterial ageing were assessed. The high numerosity of channels allowed to estimate arterial stiffness at multiple body locations, without supra-systolic cuff occlusion, providing a fast and accurate examination of cardiovascular status and potentially allowing large scale clinical screening of cardiovascular risk.