Evolving treatments and emerging strategies for tendon and ligament reconstruction

The topic of emerging trends in a certain field of research is always bound to the actual situation. As books usually have quite a long production process, emerging trends in tendon and ligament healing in this chapter refer mostly to the situation of April 2016. At that time, it was found that reports and publications mostly dealt with combinations of earlier findings to improve tendon and ligament healing by the application of especially fabricated grafts with several features addressing antiadhesion, acceleration of healing processes, and stimulation of neo-angiogenesis, among others. Moreover, cellular approaches were being investigated where transduction approaches as well as the application of cell mixtures, platelet rich plasma, or whole blood were used and shown to have beneficial effects in terms of biomechanical properties of the regenerated tendons or ligaments.

[1]  D. Mcallister,et al.  Evaluation of polycaprolactone scaffold with basic fibroblast growth factor and fibroblasts in an athymic rat model for anterior cruciate ligament reconstruction. , 2015, Tissue engineering. Part A.

[2]  D. Elliot,et al.  Primary flexor tendon surgery: the search for a perfect result. , 2013, Hand clinics.

[3]  Kai-Nan An,et al.  Biomechanical and histological effects of augmented soft tissue mobilization therapy on achilles tendinopathy in a rabbit model. , 2015, Journal of manipulative and physiological therapeutics.

[4]  Tianwu Chen,et al.  Local delivery of controlled-release simvastatin to improve the biocompatibility of polyethylene terephthalate artificial ligaments for reconstruction of the anterior cruciate ligament , 2016, International journal of nanomedicine.

[5]  L. Galatz,et al.  Tendon regeneration and scar formation: The concept of scarless healing , 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  Renato V. Iozzo,et al.  Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility , 1997, Journal of Cell Biology.

[7]  F. Collins,et al.  Evidence for a prostate cancer susceptibility locus on the X chromosome. , 1998, Nature Genetics.

[8]  M. Flury.  [Patch augmentation of the rotator cuff. A reasonable choice or a waste of money?]. , 2016, Der Orthopade.

[9]  S. Cartmell,et al.  Most British Surgeons Would Consider Using a Tissue-Engineered Anterior Cruciate Ligament: A Questionnaire Study , 2012, Stem cells international.

[10]  Andrea L. Lalley,et al.  Improved biomechanical and biological outcomes in the MRL/MpJ murine strain following a full‐length patellar tendon injury , 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[11]  N. Maffulli,et al.  Role of xenogenous bovine platelet gel embedded within collagen implant on tendon healing: an in vitro and in vivo study , 2015, Experimental biology and medicine.

[12]  Jia Jiang,et al.  Layer-by-layer hyaluronic acid-chitosan coating promoted new collagen ingrowth into a poly(ethylene terephthalate) artificial ligament in a rabbit medical collateral ligament (MCL) reconstruction model , 2013, Journal of biomaterials science. Polymer edition.

[13]  D. Mcallister,et al.  Use of ultra‐high molecular weight polycaprolactone scaffolds for ACL reconstruction , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[14]  P. E. Müller,et al.  Klinische Versorgung von Rupturen der Rotatorenmanschette , 2015, Der Orthopäde.

[15]  Kai-Nan An,et al.  The effect of surface modification on gliding ability of decellularized flexor tendon in a canine model in vitro. , 2013, The Journal of hand surgery.

[16]  Freddie H Fu,et al.  The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation. , 2015, Biomaterials.

[17]  Yulei Gao,et al.  TOB1 Deficiency Enhances the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Tendon-Bone Healing in a Rat Rotator Cuff Repair Model , 2016, Cellular Physiology and Biochemistry.

[18]  J. Fisher,et al.  A biomechanical characterisation of acellular porcine super flexor tendons for use in anterior cruciate ligament replacement: Investigation into the effects of fat reduction and bioburden reduction bioprocesses , 2015, Journal of biomechanics.

[19]  M. Flury.  Patch-Augmentation der Rotatorenmanschette , 2016, Der Orthopäde.

[20]  D. Lindsey,et al.  Decellularized human tendon-bone grafts for composite flexor tendon reconstruction: a cadaveric model of initial mechanical properties. , 2013, The Journal of hand surgery.

[21]  W. Lineaweaver,et al.  Effect of taurine on rat Achilles tendon healing , 2015, Connective tissue research.

[22]  J. Machan,et al.  Addition of Autologous Mesenchymal Stem Cells to Whole Blood for Bioenhanced ACL Repair Has No Benefit in the Porcine Model , 2015, The American journal of sports medicine.

[23]  Yilin Cao,et al.  Tissue Engineering of Tendons: A Comparison of Muscle-Derived Cells, Tenocytes, and Dermal Fibroblasts as Cell Sources , 2016, Plastic and reconstructive surgery.

[24]  S. Goldstein,et al.  Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice , 1998, Nature Genetics.

[25]  Shih-Hsien Chen,et al.  Dual functional core-sheath electrospun hyaluronic acid/polycaprolactone nanofibrous membranes embedded with silver nanoparticles for prevention of peritendinous adhesion. , 2015, Acta biomaterialia.

[26]  K. An,et al.  Effects of lubricant and autologous bone marrow stromal cell augmentation on immobilized flexor tendon repairs , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[27]  J. Machan,et al.  Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction , 2015, Knee Surgery, Sports Traumatology, Arthroscopy.

[28]  Jing-Cong Luo,et al.  Preparation and characterization of decellularized tendon slices for tendon tissue engineering. , 2012, Journal of biomedical materials research. Part A.

[29]  Xin Zhang,et al.  Runx2-Modified Adipose-Derived Stem Cells Promote Tendon Graft Integration in Anterior Cruciate Ligament Reconstruction , 2016, Scientific Reports.

[30]  K. An,et al.  What is the best candidate allograft for ACL reconstruction? An in vitro mechanical and histologic study in a canine model. , 2015, Journal of biomechanics.

[31]  ChangJames,et al.  Optimization of an injectable tendon hydrogel: the effects of platelet-rich plasma and adipose-derived stem cells on tendon healing in vivo. , 2015 .

[32]  G. Winter,et al.  Growth factor release by vesicular phospholipid gels: in-vitro results and application for rotator cuff repair in a rat model , 2015, BMC Musculoskeletal Disorders.

[33]  Jing-Cong Luo,et al.  Rotator cuff repair using a decellularized tendon slices graft: an in vivo study in a rabbit model , 2015, Knee Surgery, Sports Traumatology, Arthroscopy.

[34]  J. Gordon,et al.  Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model. , 2015, Journal of biomechanics.