Antibody-Guided Molecular Imaging of Aspergillus Lung Infections in Leukemia Patients

, I nvasive pulmonary aspergillosis (IPA) caused by the fungus Aspergillus fumigatus (Fig. 1A) is a life-threatening lung disease of acute myeloid leukemia patients, with the diagnosis currently being reliant on invasive, slow, or nonspeci fi c procedures, includ-ing chest CT ( 1 ). Here, we showcase the (to our knowledge) fi rst-time use in humans of an Aspergillus -speci fi c radiotracer ( 2,3 ) administered to acute myeloid leukemia patients diagnosed with no IPA or with IPA according to consensus de fi nitions of the disease. The subjects underwent 64 Cu-NODAGA-hJF5-PET/ MRI on a compassionate-use basis according to the German Medicinal Products Act (Arzneimittelgesetz Scienti fi c analysis was approved by the institutional review board (approval Written informed consent was obtained from all patients.Uptake of the tracer in pulmonary lesions was determined using PET/ MRI 15 18 h after intravenous injection with 196 – 287 MBq (Figs. 1B and 1C). In patient 1, no tracer