Antibody-protein binding and conformational changes: identifying allosteric signalling pathways to engineer a better effector response

[1]  D. Lane,et al.  Author Correction: The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding , 2018, Scientific Reports.

[2]  P. Mulheran,et al.  Thinking outside the Laboratory: Analyses of Antibody Structure and Dynamics within Different Solvent Environments in Molecular Dynamics (MD) Simulations , 2018, Antibodies.

[3]  Grain and starch granule morphology in superior and inferior kernels of maize in response to nitrogen , 2018, Scientific Reports.

[4]  D. Lane,et al.  The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding , 2018, Scientific Reports.

[5]  P. F. Vasconcelos,et al.  In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus , 2018, Scientific Reports.

[6]  Ruth Nussinov,et al.  Mechanisms of recognition of amyloid-β (Aβ) monomer, oligomer, and fibril by homologous antibodies , 2017, The Journal of Biological Chemistry.

[7]  D. Cullen,et al.  Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction , 2015, BMC Biotechnology.

[8]  D. Salunke,et al.  Antibody promiscuity: Understanding the paradigm shift in antigen recognition , 2015, IUBMB life.

[9]  Harry Jubb,et al.  Protein-protein interactions as druggable targets: recent technological advances. , 2013, Current opinion in pharmacology.

[10]  Yanay Ofran,et al.  A Systematic Comparison of Free and Bound Antibodies Reveals Binding-Related Conformational Changes , 2012, The Journal of Immunology.

[11]  L. Lopalco,et al.  Isotype modulates epitope specificity, affinity, and antiviral activities of anti–HIV-1 human broadly neutralizing 2F5 antibody , 2012, Proceedings of the National Academy of Sciences.

[12]  G. Raghunathan,et al.  Antigen‐binding site anatomy and somatic mutations in antibodies that recognize different types of antigens , 2012, Journal of molecular recognition : JMR.

[13]  Andrew C. R. Martin,et al.  Analysis and prediction of VH/VL packing in antibodies. , 2010, Protein engineering, design & selection : PEDS.

[14]  Kengo Kinoshita,et al.  Domain distribution and intrinsic disorder in hubs in the human protein–protein interaction network , 2010, Protein science : a publication of the Protein Society.

[15]  K. Shitara,et al.  Engineered therapeutic antibodies with improved effector functions , 2009, Cancer science.

[16]  A. Casadevall,et al.  The Immunoglobulin Heavy Chain Constant Region Affects Kinetic and Thermodynamic Parameters of Antibody Variable Region Interactions with Antigen* , 2007, Journal of Biological Chemistry.

[17]  M. Ultsch,et al.  Structure-Function Studies of Two Synthetic Anti-vascular Endothelial Growth Factor Fabs and Comparison with the Avastin™ Fab* , 2006, Journal of Biological Chemistry.

[18]  J. C. Almagro,et al.  Identification of differences in the specificity‐determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoires , 2004, Journal of molecular recognition : JMR.

[19]  Mayuko Takeda-Shitaka,et al.  Interaction between the antigen and antibody is controlled by the constant domains: Normal mode dynamics of the HEL–HyHEL‐10 complex , 2003, Protein science : a publication of the Protein Society.

[20]  Andrew C. R. Martin,et al.  Analysis of the antigen combining site: correlations between length and sequence composition of the hypervariable loops and the nature of the antigen. , 2003, Journal of molecular biology.

[21]  S. Pongor,et al.  A normalized root‐mean‐spuare distance for comparing protein three‐dimensional structures , 2001, Protein science : a publication of the Protein Society.

[22]  P. Alzari,et al.  Can isotype switch modulate antigen‐binding affinity and influence clonal selection? , 2000, European journal of immunology.

[23]  T. Honjo,et al.  Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme , 2000, Cell.

[24]  T. A. Hall,et al.  BIOEDIT: A USER-FRIENDLY BIOLOGICAL SEQUENCE ALIGNMENT EDITOR AND ANALYSIS PROGRAM FOR WINDOWS 95/98/ NT , 1999 .

[25]  M. Buckle,et al.  Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies? , 1996, The Journal of clinical investigation.

[26]  Andrew J. Martin,et al.  Antibody-antigen interactions: contact analysis and binding site topography. , 1996, Journal of molecular biology.

[27]  K Schulten,et al.  VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.

[28]  C. J. Oss.  Hydrophobic, hydrophilic and other interactions in epitope-paratope binding. , 1995 .

[29]  R. Poljak,et al.  Structural features of the reactions between antibodies and protein antigens , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  Chantal Abergel,et al.  Identification of specificity‐determining residues in antibodies , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  C. V. van Oss.  Hydrophobic, hydrophilic and other interactions in epitope-paratope binding. , 1995, Molecular immunology.

[32]  J. Thornton,et al.  Satisfying hydrogen bonding potential in proteins. , 1994, Journal of molecular biology.

[33]  E. Padlan,et al.  Anatomy of the antibody molecule. , 1994, Molecular immunology.

[34]  D. Webster,et al.  Antibody-antigen interactions , 1994 .

[35]  R L Stanfield,et al.  Antibody-antigen interactions: new structures and new conformational changes. , 1994, Current opinion in structural biology.

[36]  Klaus Rajewsky,et al.  Intraclonal generation of antibody mutants in germinal centres , 1991, Nature.

[37]  Ian Mac Lennan,et al.  The centre of hypermutation , 1991, Nature.

[38]  E. Kabat,et al.  Sequences of proteins of immunological interest , 1991 .

[39]  R. Porter,et al.  Parapepsins: two proteolytic enzymes associated with porcine pepsin. , 1959, The Biochemical journal.

[40]  R. Porter.  The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. , 1959, The Biochemical journal.