Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics.

A total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of genes encoding modular polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). We report on the distribution of these systems in different bacterial taxa and, whenever known, the metabolites they synthesize. We also highlight, in the different bacterial lineages, the PKS and NRPS genes and, whenever known, the corresponding products.

[1]  R. Barrangou,et al.  Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[2]  J. Hofemeister,et al.  Genetic analysis of the biosynthesis of non-ribosomal peptide- and polyketide-like antibiotics, iron uptake and biofilm formation by Bacillus subtilis A1/3 , 2004, Molecular Genetics and Genomics.

[3]  E. C. Teixeira,et al.  Comparison of the genomes of two Xanthomonas pathogens with differing host specificities , 2002, Nature.

[4]  Mark Borodovsky,et al.  The complete genome sequence of the gastric pathogen Helicobacter pylori , 1997, Nature.

[5]  Y. Nagai,et al.  Genome and virulence determinants of high virulence community-acquired MRSA , 2002, The Lancet.

[6]  R. Schoenfeld,et al.  Comparative Genomics of Listeria Species , 1976 .

[7]  Todd M. Smith,et al.  Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[8]  M. Daffé,et al.  The Acyl-AMP Ligase FadD32 and AccD4-containing Acyl-CoA Carboxylase Are Required for the Synthesis of Mycolic Acids and Essential for Mycobacterial Growth , 2005, Journal of Biological Chemistry.

[9]  Hyungtae Kim,et al.  The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331, the bacterial blight pathogen of rice , 2005, Nucleic acids research.

[10]  D. Gross,et al.  Pseudomonas syringae Phytotoxins: Mode of Action, Regulation, and Biosynthesis by Peptide and Polyketide Synthetases , 1999, Microbiology and Molecular Biology Reviews.

[11]  G. Mahairas,et al.  The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low). , 2003, Microbiology.

[12]  Jürgen Gadau,et al.  The genome sequence of Blochmannia floridanus: Comparative analysis of reduced genomes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  S. Salzberg,et al.  Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae , 2001, Science.

[14]  M. Simmonds,et al.  Genome sequence of Yersinia pestis, the causative agent of plague , 2001, Nature.

[15]  M. Daffé,et al.  Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene. , 2002, The Journal of biological chemistry.

[16]  W. F. Fricke,et al.  Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans , 2005, Nature Biotechnology.

[17]  S. Salzberg,et al.  The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria , 2003, Nature.

[18]  Rekha R Meyer,et al.  Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid , 2004, Nature Genetics.

[19]  Jie Dong,et al.  Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery , 2005, Nucleic acids research.

[20]  G. Mahairas,et al.  The Genome Sequence of Mycoplasma hyopneumoniae Strain 232, the Agent of Swine Mycoplasmosis , 2004, Journal of bacteriology.

[21]  O. White,et al.  Genome sequence of the dissimilatory metal ion–reducing bacterium Shewanella oneidensis , 2002, Nature Biotechnology.

[22]  J. Ravel,et al.  Genomics of the group of organisms , 2005 .

[23]  M. Bibb,et al.  Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes. , 2001, Chemistry & biology.

[24]  M. Hattori,et al.  Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Rino Rappuoli,et al.  Post‐genomic vaccine development , 2006, FEBS letters.

[26]  Sung-Heui Shin,et al.  Production of catechol-siderophore and utilization of transferrin-bound iron in Bacillus cereus. , 2005, Biological & pharmaceutical bulletin.

[27]  C. Walsh,et al.  Biological formation of pyrroles: nature's logic and enzymatic machinery. , 2006, Natural product reports.

[28]  B. Barrell,et al.  Massive gene decay in the leprosy bacillus , 2001, Nature.

[29]  Sylvie Lautru,et al.  Discovery of a new peptide natural product by Streptomyces coelicolor genome mining , 2005, Nature chemical biology.

[30]  R. Wilson,et al.  Complete genome sequence of Salmonella enterica serovar Typhimurium LT2 , 2001, Nature.

[31]  R. Reinhardt,et al.  The mycosubtilin synthetase of Bacillus subtilis ATCC6633: a multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Ian T. Paulsen,et al.  Complete genome sequence of Caulobacter crescentus , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[33]  A. Goesmann,et al.  The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. , 2003, Journal of biotechnology.

[34]  Mohamed A. Marahiel,et al.  Chemoenzymatic and Template-Directed Synthesis of Bioactive Macrocyclic Peptides , 2006, Microbiology and Molecular Biology Reviews.

[35]  R. Rappuoli,et al.  Vaccinology at the beginning of the 21st century , 2005, Current Opinion in Immunology.

[36]  B. Barrell,et al.  The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129. , 2003, Nucleic acids research.

[37]  M. Hattori,et al.  Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. , 2001, DNA research : an international journal for rapid publication of reports on genes and genomes.

[38]  M. Marahiel,et al.  The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases. , 1997, Chemistry & biology.

[39]  A. Ankai,et al.  Whole-Genome Sequencing of Staphylococcus haemolyticus Uncovers the Extreme Plasticity of Its Genome and the Evolution of Human-Colonizing Staphylococcal Species , 2005, Journal of bacteriology.

[40]  A. Kondorosi,et al.  The rkpGHI and -J genes are involved in capsular polysaccharide production by Rhizobium meliloti , 1997, Journal of bacteriology.

[41]  Alfonso Valencia,et al.  Reductive genome evolution in Buchnera aphidicola , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Patrick Wincker,et al.  Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium. , 2004, Nucleic acids research.

[43]  Alan T. Bull,et al.  Search and Discovery Strategies for Biotechnology: the Paradigm Shift , 2000, Microbiology and Molecular Biology Reviews.

[44]  G. Salmond,et al.  The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation. , 2004, Microbiology.

[45]  Meng-Yao Liu,et al.  Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Michael S. Gilmore,et al.  Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis , 2002, Nature.

[47]  H. J. Kim,et al.  Copper-Binding Compounds from Methylosinus trichosporium OB3b , 1998, Journal of bacteriology.

[48]  P. Kolattukudy,et al.  Molecular cloning and sequencing of the gene for mycocerosic acid synthase, a novel fatty acid elongating multifunctional enzyme, from Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. , 1992, The Journal of biological chemistry.

[49]  S. Salzberg,et al.  Complete genome sequence of Treponema pallidum, the syphilis spirochete. , 1998, Science.

[50]  C. Médigue,et al.  Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Masahira Hattori,et al.  Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. , 2003, Genome research.

[52]  G H Goldman,et al.  Comparative Analyses of the Complete Genome Sequences of Pierce's Disease and Citrus Variegated Chlorosis Strains of Xylella fastidiosa , 2003, Journal of bacteriology.

[53]  P. Degnan,et al.  Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects. , 2005, Genome research.

[54]  M. Ikeuchi,et al.  Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1. , 2002, DNA research : an international journal for rapid publication of reports on genes and genomes.

[55]  C. Fraser,et al.  The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Hattori,et al.  The complete genomic sequence of Nocardia farcinica IFM 10152. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[57]  P. Dürre,et al.  The Complete Genome Sequence of Propionibacterium Acnes, a Commensal of Human Skin , 2004, Science.

[58]  C. Walsh,et al.  Post-translational modification of polyketide and nonribosomal peptide synthases. , 1997, Current opinion in chemical biology.

[59]  D. Expert,et al.  Chrysobactin-dependent iron acquisition in Erwinia chrysanthemi. Functional study of a homolog of the Escherichia coli ferric enterobactin esterase. , 2002, The Journal of biological chemistry.

[60]  Kim Rutherford,et al.  Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[61]  Yoshiyuki Sakaki,et al.  Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[62]  P. Jagtap,et al.  A Predator Unmasked: Life Cycle of Bdellovibrio bacteriovorus from a Genomic Perspective , 2004, Science.

[63]  J. Musser,et al.  Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain. , 2004, The Journal of infectious diseases.

[64]  Ronald W. Davis,et al.  Comparative genomes of Chlamydia pneumoniae and C. trachomatis , 1999, Nature Genetics.

[65]  Ian T. Paulsen,et al.  Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment , 2004, Nature.

[66]  E. Greenberg,et al.  Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[67]  Michael Kube,et al.  The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1 , 2004, Archives of Microbiology.

[68]  F. Blattner,et al.  A Genomic Sample Sequence of the Entomopathogenic Bacterium Photorhabdus luminescens W14: Potential Implications for Virulence , 2000, Applied and Environmental Microbiology.

[69]  A. Danchin,et al.  Genome‐based analysis of virulence genes in a non‐biofilm‐forming Staphylococcus epidermidis strain (ATCC 12228) , 2003, Molecular microbiology.

[70]  Sang Yup Lee,et al.  The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens , 2004, Nature Biotechnology.

[71]  J. Claverie,et al.  The Genome Sequence of Rickettsia felis Identifies the First Putative Conjugative Plasmid in an Obligate Intracellular Parasite , 2005, PLoS biology.

[72]  M. Andersson,et al.  Identification and Partial Characterization of the Nonribosomal Peptide Synthetase Gene Responsible for Cereulide Production in Emetic Bacillus cereus , 2005, Applied and Environmental Microbiology.

[73]  W. Degrave,et al.  Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis , 2004, Journal of bacteriology.

[74]  S. Tabata,et al.  Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110. , 2002, DNA research : an international journal for rapid publication of reports on genes and genomes.

[75]  Hyun Seok Park,et al.  The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4 , 2005, Nature Biotechnology.

[76]  S. Malfatti,et al.  Whole-Genome Analyses of Speciation Events in Pathogenic Brucellae , 2005, Infection and Immunity.

[77]  B. Barrell,et al.  The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences , 2000, Nature.

[78]  M. Hattori,et al.  Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[79]  Tilmann Weber,et al.  Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs) , 2005, Nucleic acids research.

[80]  J. Lamerdin,et al.  Complete Genome Sequence of the Ammonia-Oxidizing Bacterium and Obligate Chemolithoautotroph Nitrosomonas europaea , 2003, Journal of bacteriology.

[81]  F. Young.  Biochemistry , 1955, The Indian Medical Gazette.

[82]  Y. Nakamura,et al.  Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. , 2000, DNA research : an international journal for rapid publication of reports on genes and genomes.

[83]  C. Walsh,et al.  Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria , 2002, Microbiology and Molecular Biology Reviews.

[84]  Guangwei Fan,et al.  Complete Genome Sequence of Rickettsia typhi and Comparison with Sequences of Other Rickettsiae , 2004, Journal of bacteriology.

[85]  R. Fleischmann,et al.  The Minimal Gene Complement of Mycoplasma genitalium , 1995, Science.

[86]  G. Weinstock,et al.  Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[87]  B. Barrell,et al.  Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei , 2003, The Lancet.

[88]  Ian T. Paulsen,et al.  Complete Genome Sequence of the Oral Pathogenic Bacterium Porphyromonas gingivalis Strain W83 , 2003, Journal of bacteriology.

[89]  J. Bonmatin,et al.  Recent trends in the biochemistry of surfactin , 1999, Applied Microbiology and Biotechnology.

[90]  M. Marahiel,et al.  The dhb Operon of Bacillus subtilisEncodes the Biosynthetic Template for the Catecholic Siderophore 2,3-Dihydroxybenzoate-Glycine-Threonine Trimeric Ester Bacillibactin* , 2001, The Journal of Biological Chemistry.

[91]  Jean-Marie Meyer,et al.  Pyoverdines: pigments, siderophores and potential taxonomic markers of fluorescent Pseudomonas species , 2000, Archives of Microbiology.

[92]  E. de Hoffmann,et al.  Yersiniabactin Production by Pseudomonas syringae and Escherichia coli, and Description of a Second Yersiniabactin Locus Evolutionary Group , 2006, Applied and Environmental Microbiology.

[93]  B. Barrell,et al.  Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica , 2003, Nature Genetics.

[94]  J Sühnel,et al.  Comparative analysis of the Borrelia garinii genome. , 2004, Nucleic acids research.

[95]  C. R. Howell.  Suppression of Pythium ultimum-induced damping-off of cotton seedlings by Pseudomonas fluorescens and its antibiotic, pyoluteorin. , 1980 .

[96]  David A Rasko,et al.  Genomics of the Bacillus cereus group of organisms. , 2005, FEMS microbiology reviews.

[97]  P. Hanna,et al.  Bacillus anthracis requires siderophore biosynthesis for growth in macrophages and mouse virulence , 2004, Molecular microbiology.

[98]  Rodolphe Barrangou,et al.  The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[99]  Kira J. Weissman,et al.  Combinatorial biosynthesis of reduced polyketides , 2005, Nature Reviews Microbiology.

[100]  Ronald W. Davis,et al.  The Composite Genome of the Legume Symbiont Sinorhizobium meliloti , 2001, Science.

[101]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[102]  C R Hutchinson,et al.  Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. , 2001, Biochemistry.

[103]  S. Schuster,et al.  Insights into Genome Plasticity and Pathogenicity of the Plant Pathogenic Bacterium Xanthomonas campestris pv. vesicatoria Revealed by the Complete Genome Sequence , 2005, Journal of bacteriology.

[104]  J. Handelsman,et al.  Genetics of Zwittermicin A Production by Bacillus cereus , 2004, Applied and Environmental Microbiology.

[105]  M. Kleerebezem,et al.  Complete genome sequence of Lactobacillus plantarum WCFS1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[106]  N. W. Davis,et al.  Genome sequence of enterohaemorrhagic Escherichia coli O157:H7 , 2001, Nature.

[107]  H. Hilbert,et al.  Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. , 1996, Nucleic acids research.

[108]  S. Ehrlich,et al.  The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403. , 2001, Genome research.

[109]  Michal J. Nagiec,et al.  Genome sequence of a serotype M28 strain of group a streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity. , 2005, The Journal of infectious diseases.

[110]  Peer Bork,et al.  The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[111]  M. J. Park,et al.  Symbiobacterium thermophilum gen. nov., sp. nov., a symbiotic thermophile that depends on co-culture with a Bacillus strain for growth. , 2000, International journal of systematic and evolutionary microbiology.

[112]  Wei Wei,et al.  Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma , 2004, Nature Genetics.

[113]  A. Goffeau,et al.  Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus , 2004, Nature Biotechnology.

[114]  N. Moran,et al.  50 Million Years of Genomic Stasis in Endosymbiotic Bacteria , 2002, Science.

[115]  R. Huber,et al.  The complete genome of the hyperthermophilic bacterium Aquifex aeolicus , 1998, Nature.

[116]  B. Barrell,et al.  Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491 , 2000, Nature.

[117]  S. Campanaro,et al.  Life at Depth: Photobacterium profundum Genome Sequence and Expression Analysis , 2005, Science.

[118]  Elliot J. Lefkowitz,et al.  Genome of the Bacterium Streptococcus pneumoniae Strain R6 , 2001, Journal of bacteriology.

[119]  C. Litwin,et al.  Role of catechol siderophore synthesis in Vibrio vulnificus virulence , 1996, Infection and immunity.

[120]  Katherine H. Kang,et al.  Genomic Insights into Methanotrophy: The Complete Genome Sequence of Methylococcus capsulatus (Bath) , 2004, PLoS biology.

[121]  P. Sokol.  Production and utilization of pyochelin by clinical isolates of Pseudomonas cepacia , 1986, Journal of clinical microbiology.

[122]  C. Hertweck,et al.  Biosynthesis of polyunsaturated fatty acids by polyketide synthases. , 2002, Angewandte Chemie.

[123]  Jacob D. Jaffe,et al.  The complete genome and proteome of Mycoplasma mobile. , 2004, Genome research.

[124]  Samuel V. Angiuoli,et al.  Insights on Evolution of Virulence and Resistance from the Complete Genome Analysis of an Early Methicillin-Resistant Staphylococcus aureus Strain and a Biofilm-Producing Methicillin-Resistant Staphylococcus epidermidis Strain , 2005, Journal of bacteriology.

[125]  Rainer Merkl,et al.  The genome sequence of the extreme thermophile Thermus thermophilus , 2004, Nature Biotechnology.

[126]  Carmen Buchrieser,et al.  Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease , 2002, Molecular microbiology.

[127]  J. Weissenbach,et al.  Mechanisms of Evolution in Rickettsia conorii and R. prowazekii , 2001, Science.

[128]  M. Hattori,et al.  Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS , 2000, Nature.

[129]  Rekha Seshadri,et al.  Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5 , 2005, Nature Biotechnology.

[130]  K. Tsuge,et al.  The Genes degQ, pps, and lpa-8(sfp) Are Responsible for Conversion of Bacillus subtilis 168 to Plipastatin Production , 1999, Antimicrobial Agents and Chemotherapy.

[131]  Y. Nakamura,et al.  Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions (supplement). , 1996, DNA research : an international journal for rapid publication of reports on genes and genomes.

[132]  S. Salzberg,et al.  DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae , 2000, Nature.

[133]  Rainer Merkl,et al.  The genome sequence of Clostridium tetani, the causative agent of tetanus disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[134]  R. Roop,et al.  Genetic Organization and Iron-Responsive Regulation of the Brucella abortus 2,3-Dihydroxybenzoic Acid Biosynthesis Operon, a Cluster of Genes Required for Wild-Type Virulence in Pregnant Cattle , 2003, Infection and Immunity.

[135]  Andrew C. Tolonen,et al.  The genome of a motile marine Synechococcus , 2003, Nature.

[136]  P. Caffrey.  The stereochemistry of ketoreduction. , 2005, Chemistry & biology.

[137]  A. Amonsin,et al.  The complete genome sequence of Mycobacterium avium subspecies paratuberculosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[138]  B. Barrell,et al.  Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) , 2002, Nature.

[139]  Guy Plunkett,et al.  Comparative Genomics of Salmonellaenterica Serovar Typhi Strains Ty2 and CT18 , 2003, Journal of bacteriology.

[140]  A. Goffeau,et al.  The complete genome sequence of the Gram-positive bacterium Bacillus subtilis , 1997, Nature.

[141]  H. Sprecher,et al.  The Mycobacterium tuberculosis pks2 Gene Encodes the Synthase for the Hepta- and Octamethyl-branched Fatty Acids Required for Sulfolipid Synthesis* , 2001, The Journal of Biological Chemistry.

[142]  T. Sicheritz-Pontén,et al.  The genome sequence of Rickettsia prowazekii and the origin of mitochondria , 1998, Nature.

[143]  Yoshiyuki Sakaki,et al.  Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis , 2003, Nature Biotechnology.

[144]  Hidemi Watanabe,et al.  Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia , 2002, Nature Genetics.

[145]  Jaideep P. Sundaram,et al.  Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[146]  S. Gould,et al.  Characterization of the Pyoluteorin Biosynthetic Gene Cluster of Pseudomonas fluorescens Pf-5 , 1999, Journal of bacteriology.

[147]  Ling V. Sun,et al.  Phylogenomics of the Reproductive Parasite Wolbachia pipientis wMel: A Streamlined Genome Overrun by Mobile Genetic Elements , 2004, PLoS biology.

[148]  Lisa C. Crossman,et al.  Extensive DNA Inversions in the B. fragilis Genome Control Variable Gene Expression , 2005, Science.

[149]  G. Besra,et al.  Mycobacterium tuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells , 2004, The Journal of experimental medicine.

[150]  E. Karlberg,et al.  The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[151]  S Omura,et al.  Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[152]  V. Loux,et al.  The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K , 2005, Nature Biotechnology.

[153]  J. Ravel,et al.  Genomics of pyoverdine-mediated iron uptake in pseudomonads. , 2003, Trends in microbiology.

[154]  F. Sangari,et al.  Brucella abortus strain 2308 produces brucebactin, a highly efficient catecholic siderophore. , 2002, Microbiology.

[155]  B. Barrell,et al.  The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation. , 2005, Genome research.

[156]  Eriko Takano,et al.  A bacterial hormone (the SCB1) directly controls the expression of a pathway‐specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor , 2005, Molecular microbiology.

[157]  David A Rasko,et al.  Major Structural Differences and Novel Potential Virulence Mechanisms from the Genomes of Multiple Campylobacter Species , 2005, PLoS biology.

[158]  Michael Y. Galperin,et al.  Genome sequence of the deep-sea γ-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[159]  J. Claverie,et al.  Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome. , 2003, Genome research.

[160]  E. Kimura,et al.  Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens. , 2003, Genome research.

[161]  J. Musser,et al.  Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events. , 2005, The Journal of infectious diseases.

[162]  Ingeborg Holt,et al.  The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[163]  M Achtman,et al.  Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[164]  Songnian Hu,et al.  The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen , 2005, Nucleic acids research.

[165]  Yan P. Yuan,et al.  Re-annotating the Mycoplasma pneumoniae genome sequence: adding value, function and reading frames. , 2000, Nucleic acids research.

[166]  S M Payne,et al.  Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T , 2003, Infection and Immunity.

[167]  M. Hattori,et al.  Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism. , 2004, Nucleic acids research.

[168]  Folker Meyer,et al.  Complete genome sequence and analysis of Wolinella succinogenes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[169]  Robert Finking,et al.  Biosynthesis of nonribosomal peptides , 2003 .

[170]  M. Mimuro,et al.  Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids. , 2003, DNA research : an international journal for rapid publication of reports on genes and genomes.

[171]  A. Kondorosi,et al.  Novel rkp Gene Clusters ofSinorhizobium meliloti Involved in Capsular Polysaccharide Production and Invasion of the Symbiotic Nodule: the rkpKGene Encodes a UDP-Glucose Dehydrogenase , 1998, Journal of bacteriology.

[172]  Eriko Takano,et al.  A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2) , 2007, Archives of Microbiology.

[173]  O. White,et al.  Structural flexibility in the Burkholderia mallei genome. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[174]  S. Salzberg,et al.  Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. , 2000, Nucleic acids research.

[175]  W. Nierman,et al.  Bacterial genome adaptation to niches: Divergence of the potential virulence genes in three Burkholderia species of different survival strategies , 2005, BMC Genomics.

[176]  M. Noordewier,et al.  Genome Streamlining in a Cosmopolitan Oceanic Bacterium , 2005, Science.

[177]  Shih-Feng Tsai,et al.  Comparative genome analysis of Vibrio vulnificus, a marine pathogen. , 2003, Genome research.

[178]  Jie Dong,et al.  Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. , 2002, Nucleic acids research.

[179]  P. Watnick,et al.  Vibrio cholerae VibF Is Required for Vibriobactin Synthesis and Is a Member of the Family of Nonribosomal Peptide Synthetases , 2000, Journal of bacteriology.

[180]  S. Salzberg,et al.  Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. , 2000, Science.

[181]  O. White,et al.  Transposition Pathovars in Genes Involved in Virulence 1448 A Reveals Divergence among pv . phaseolicola Pseudomonas syringae Whole-Genome Sequence Analysis of , 2005 .

[182]  C. Walsh,et al.  Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. , 1998, Chemistry & biology.

[183]  J. Waterbury,et al.  Distribution and Diversity of Natural Product Genes in Marine and Freshwater Cyanobacterial Cultures and Genomes , 2005, Applied and Environmental Microbiology.

[184]  Ikuo Uchiyama,et al.  Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus. , 2004, Nucleic acids research.

[185]  Christine J. Martin,et al.  Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity. , 2004, Natural product reports.

[186]  D. Graham,et al.  Isolation of Copper Biochelates fromMethylosinus trichosporium OB3b and Soluble Methane Monooxygenase Mutants , 1998, Applied and Environmental Microbiology.

[187]  Jia Liu,et al.  The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[188]  N. W. Davis,et al.  The complete genome sequence of Escherichia coli K-12. , 1997, Science.

[189]  E. Rocha,et al.  The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis. , 2001, Nucleic acids research.

[190]  Benjamin L. King,et al.  Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori , 1999, Nature.

[191]  A. Danchin,et al.  The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens , 2003, Nature Biotechnology.

[192]  George N. Bennett,et al.  Genome Sequence and Comparative Analysis of the Solvent-Producing Bacterium Clostridium acetobutylicum , 2001, Journal of bacteriology.

[193]  Bertil Pettersson,et al.  The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP). , 2004, Genome research.

[194]  S. Salzberg,et al.  Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima , 1999, Nature.

[195]  B. Barrell,et al.  Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence , 1998, Nature.

[196]  Luiz R Nunes,et al.  The genome sequence of the gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli. , 2004, Molecular plant-microbe interactions : MPMI.

[197]  D. A. Palmieri,et al.  The genome sequence of the plant pathogen Xylella fastidiosa , 2000, Nature.

[198]  Nikos Kyrpides,et al.  Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis , 2003, Nature.

[199]  C. Ferraz,et al.  Comparative Genomic Analysis of Three Strains of Ehrlichia ruminantium Reveals an Active Process of Genome Size Plasticity , 2006, Journal of bacteriology.

[200]  Gregory L. Challis,et al.  Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[201]  Luke E. Ulrich,et al.  Life in Hot Carbon Monoxide: The Complete Genome Sequence of Carboxydothermus hydrogenoformans Z-2901 , 2005, PLoS genetics.

[202]  A. Hill.  The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites. , 2006, Natural product reports.

[203]  B. Barrell,et al.  Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[204]  M. Rosenberg,et al.  Exploiting genomics to discover new antibiotics. , 2001, Trends in microbiology.

[205]  M. Hattori,et al.  Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[206]  M. Hattori,et al.  The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans. , 2002, Nucleic acids research.

[207]  J. Weissenbach,et al.  Genome sequence of the plant pathogen Ralstonia solanacearum , 2002, Nature.

[208]  W. Wolfson.  Anadys uses toll-like receptors to switch on immunity. , 2007, Chemistry & biology.

[209]  G. Besra,et al.  Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis , 2005, Clinical Microbiology Reviews.

[210]  J. Meeks,et al.  A polyketide-synthase-like gene is involved in the synthesis of heterocyst glycolipids in Nostoc punctiforme strain ATCC 29133 , 1997, Archives of Microbiology.

[211]  S. Salzberg,et al.  Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. , 1999, Science.

[212]  G. Besra,et al.  Transposon Mutagenesis of Mb0100 at the ppe1-nrp Locus in Mycobacterium bovis Disrupts Phthiocerol Dimycocerosate (PDIM) and Glycosylphenol-PDIM Biosynthesis, Producing an Avirulent Strain with Vaccine Properties At Least Equal to Those of M. bovis BCG , 2005, Journal of bacteriology.

[213]  Zhang Qing,et al.  Completion of the Genome Sequence of Brucella abortus and Comparison to the Highly Similar Genomes of Brucella melitensis and Brucella suis , 2005, Journal of bacteriology.

[214]  D. Mohanty,et al.  A genetic locus required for iron acquisition in Mycobacterium tuberculosis , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[215]  M. Kanehisa,et al.  Whole genome sequencing of meticillin-resistant Staphylococcus aureus , 2001, The Lancet.

[216]  Guy Plunkett,et al.  Genome Sequence of Yersinia pestis KIM , 2002, Journal of bacteriology.

[217]  O. White,et al.  Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440. , 2002, Environmental microbiology.

[218]  J A Eisen,et al.  Genome of Geobacter sulfurreducens: Metal Reduction in Subsurface Environments , 2003, Science.

[219]  Ian T. Paulsen,et al.  Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[220]  R. Christen,et al.  Elevation of three subspecies of Pectobacterium carotovorum to species level: Pectobacterium atrosepticum sp. nov., Pectobacterium betavasculorum sp. nov. and Pectobacterium wasabiae sp. nov. , 2003, International journal of systematic and evolutionary microbiology.

[221]  William C. Ray,et al.  Genomic Sequence of an Otitis Media Isolate of Nontypeable Haemophilus influenzae: Comparative Study with H. influenzae Serotype d, Strain KW20 , 2005, Journal of bacteriology.

[222]  A. Danchin,et al.  Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing , 2003, Nature.

[223]  Matt Nolan,et al.  Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[224]  Dmitrij Frishman,et al.  Illuminating the Evolutionary History of Chlamydiae , 2004, Science.

[225]  C. Walsh,et al.  Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. , 2002, Chemistry & biology.

[226]  J. Carney,et al.  Photobactin: a Catechol Siderophore Produced by Photorhabdus luminescens, an Entomopathogen Mutually Associated with Heterorhabditis bacteriophora NC1 Nematodes , 2003, Applied and Environmental Microbiology.

[227]  David A Rasko,et al.  The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1. , 2004, Nucleic acids research.

[228]  S. Salzberg,et al.  Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi , 1997, Nature.

[229]  S. Lory,et al.  Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen , 2000, Nature.

[230]  Gurdyal S Besra,et al.  The methyl-branched fortifications of Mycobacterium tuberculosis. , 2002, Chemistry & biology.

[231]  K. Borzym,et al.  Complete genome sequence of the marine planctomycete Pirellula sp. strain 1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[232]  Gitanjali Yadav,et al.  Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases. , 2003, Journal of molecular biology.

[233]  Rainer Merkl,et al.  The Complete Genome Sequence of Bacillus licheniformis DSM13, an Organism with Great Industrial Potential , 2004, Journal of Molecular Microbiology and Biotechnology.

[234]  P. Richardson,et al.  The Genome Sequence of the Obligately Chemolithoautotrophic, Facultatively Anaerobic Bacterium Thiobacillus denitrificans , 2006, Journal of bacteriology.

[235]  M. Hattori,et al.  Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA. , 2000, Nucleic acids research.

[236]  E. Dittmann,et al.  Nonribosomal Peptide Synthesis and Toxigenicity of Cyanobacteria , 1999, Journal of bacteriology.

[237]  C. Buchrieser,et al.  Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity , 2004, Nature Genetics.

[238]  Natalia N. Ivanova,et al.  The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode , 2005, PLoS biology.

[239]  Nikos Kyrpides,et al.  Genome Sequence and Analysis of the Oral Bacterium Fusobacterium nucleatum Strain ATCC 25586 , 2002, Journal of bacteriology.

[240]  Michael Y. Galperin,et al.  Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[241]  C. A. Shull.  Phytopathology , 1929, Botanical Gazette.

[242]  Zhijian Yao,et al.  Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. , 2005, Genome research.

[243]  R. Rosenfeld.  Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[244]  I. Chou,et al.  The Genomic Sequence of the Accidental Pathogen Legionella pneumophila , 2004, Science.

[245]  Mohd Zeeshan Ansari,et al.  Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. , 2005, Molecular cell.

[246]  A. Scaloni,et al.  A new syringopeptin produced by bean strains of Pseudomonas syringae pv. syringae. , 2002, Biochimica et biophysica acta.

[247]  R. Amann,et al.  The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments. , 2004, Environmental microbiology.

[248]  S. Salzberg,et al.  Whole-Genome Comparison of Mycobacterium tuberculosis Clinical and Laboratory Strains , 2002, Journal of bacteriology.

[249]  Y. Nakamura,et al.  Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. , 2000, Nucleic acids research.

[250]  F. Blattner,et al.  Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[251]  Harald Gross,et al.  The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. , 2007, Chemistry & biology.

[252]  T. Stein.  Bacillus subtilis antibiotics: structures, syntheses and specific functions , 2005, Molecular microbiology.

[253]  H. H. Barnes,et al.  Purification of catechol siderophores by boronate affinity chromatography: Identification of chrysobactin from Erwinia carotovora subsp. carotovora , 1999, Biometals.

[254]  Patrick Caffrey,et al.  Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases , 2003, Chembiochem : a European journal of chemical biology.

[255]  A. Fraser,et al.  Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[256]  Haeyoung Jeong,et al.  Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent , 2005, Nucleic acids research.

[257]  Ana Tereza Ribeiro de Vasconcelos,et al.  The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[258]  Y. Nakamura,et al.  Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. , 2001, DNA research : an international journal for rapid publication of reports on genes and genomes.

[259]  Runying Tian,et al.  Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[260]  A. T. Vasconcelos,et al.  Swine and Poultry Pathogens: the Complete Genome Sequences of Two Strains of Mycoplasma hyopneumoniae and a Strain of Mycoplasma synoviae , 2005, Journal of bacteriology.

[261]  Ian T. Paulsen,et al.  The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[262]  Manor Askenazi,et al.  Genome Sequence of the Plant Pathogen and Biotechnology Agent Agrobacterium tumefaciens C58 , 2001, Science.

[263]  Huanming Yang,et al.  Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. , 2004, DNA research : an international journal for rapid publication of reports on genes and genomes.

[264]  W. Doolittle,et al.  The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[265]  Mark S. Thomas,et al.  Isolation and Characterization of Burkholderia cenocepacia Mutants Deficient in Pyochelin Production: Pyochelin Biosynthesis Is Sensitive to Sulfur Availability , 2004, Journal of bacteriology.

[266]  Kelly A Brayton,et al.  Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[267]  Masahira Hattori,et al.  Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae , 2003, The Lancet.

[268]  G. Challis,et al.  Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. , 2000, Chemistry & biology.

[269]  C. Fraser,et al.  Complete genome sequence of the Q-fever pathogen Coxiella burnetii , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[270]  H. Reichenbach,et al.  Biologically active secondary metabolites from myxobacteria. , 1993, Biotechnology advances.

[271]  Bruce A. Roe,et al.  Complete genome sequence of an M1 strain of Streptococcus pyogenes , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[272]  Jon R. Armstrong,et al.  Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[273]  H. Caldwell,et al.  Comparative Genomic Analysis of Chlamydia trachomatis Oculotropic and Genitotropic Strains , 2005, Infection and Immunity.

[274]  Fourie Joubert,et al.  The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[275]  C Richard Hutchinson,et al.  A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. , 2003, Biochemistry.

[276]  Caroline Peres,et al.  Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris , 2004, Nature Biotechnology.

[277]  H. Takami,et al.  Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments. , 2002, Nucleic acids research.

[278]  R. Müller,et al.  Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium. , 2003, Journal of biotechnology.

[279]  P. Perani,et al.  A Bacillus subtilis large ORF coding for a polypeptide highly similar to polyketide synthases. , 1993, Gene.

[280]  T. Stachelhaus,et al.  The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. , 1999, Chemistry & biology.

[281]  A. Allsop.  Bacterial genome sequencing and drug discovery. , 1998, Current opinion in biotechnology.

[282]  S. Eykyn.  Microbiology , 1950, The Lancet.

[283]  Rekha Seshadri,et al.  The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough , 2004, Nature Biotechnology.

[284]  Lynn K. Carmichael,et al.  A Genomic View of the Human-Bacteroides thetaiotaomicron Symbiosis , 2003, Science.

[285]  Natalia N. Ivanova,et al.  The genome sequence of the facultative intracellular pathogen Brucella melitensis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[286]  Manesh Shah,et al.  Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation , 2003, Nature.

[287]  G. Nyakatura,et al.  The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[288]  R. W. Davis,et al.  Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. , 1998, Science.

[289]  S Dusko Ehrlich,et al.  Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species , 2004, Genome Biology.

[290]  David A Rasko,et al.  Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species. , 2004, Nucleic acids research.

[291]  M. Marahiel,et al.  Molecular and Biochemical Characterization of the Protein Template Controlling Biosynthesis of the Lipopeptide Lichenysin , 1999, Journal of bacteriology.

[292]  J A Eisen,et al.  The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58 , 2001, Science.

[293]  R. Fleischmann,et al.  Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. , 1995, Science.

[294]  Mark Welch,et al.  Genetic approaches to polyketide antibiotics. 1. , 2005, Chemical reviews.

[295]  Jian Wang,et al.  A complete sequence of the T. tengcongensis genome. , 2002, Genome research.

[296]  Anders Sjöstedt,et al.  The complete genome sequence of Francisella tularensis, the causative agent of tularemia , 2005, Nature Genetics.

[297]  Kim Rutherford,et al.  Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18 , 2001, Nature.

[298]  J. Vaitomaa,et al.  Phylogenetic evidence for the early evolution of microcystin synthesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[299]  S. Salzberg,et al.  Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae. , 2003, Nucleic acids research.

[300]  A. Goesmann,et al.  Complete Genome Sequence and Analysis of the Multiresistant Nosocomial Pathogen Corynebacterium jeikeium K411, a Lipid-Requiring Bacterium of the Human Skin Flora , 2005, Journal of bacteriology.

[301]  M. Marahiel,et al.  4′-Phosphopantetheine Transfer in Primary and Secondary Metabolism of Bacillus subtilis * , 2001, The Journal of Biological Chemistry.

[302]  G. Challis,et al.  Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase. , 2000, FEMS microbiology letters.