Checkpoints: Chromosome pairing takes an unexpected twist

When meiotic cells complete S phase, homologous chromosomes pair, synapse and undergo recombination. A checkpoint protein is somehow required for meiotic chromosome pairing in C. elegans, thus providing a direct link between S phase and the rest of the meiotic program.

[1]  S. Milstein,et al.  A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans. , 2000, Molecular cell.

[2]  Jong-Soo Lee,et al.  hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response , 2000, Nature.

[3]  N. Kleckner,et al.  The leptotene-zygotene transition of meiosis. , 1998, Annual review of genetics.

[4]  S. Jackson,et al.  Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. , 1998, Genes & development.

[5]  S. Strome,et al.  Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation. , 1999, Genes & development.

[6]  R. Hawley,et al.  Requiem for distributive segregation: achiasmate segregation in Drosophila females. , 1993, Trends in genetics : TIG.

[7]  C. Barlow,et al.  The association of ATR protein with mouse meiotic chromosome cores , 1999, Chromosoma.

[8]  A. Villeneuve,et al.  Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis , 1998, Cell.

[9]  C. Westphal,et al.  Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes , 1997, Current Biology.

[10]  R. Camerini-Otero,et al.  The mouse Spo11 gene is required for meiotic chromosome synapsis. , 2000, Molecular cell.

[11]  N. Rhind,et al.  Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. , 2000, Journal of cell science.

[12]  G. Stanfield,et al.  Caenorhabditis elegans msh-5 is required for both normal and radiation-induced meiotic crossing over but not for completion of meiosis. , 2000, Genetics.

[13]  G. Roeder,et al.  A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. , 1991, Genes & development.

[14]  P. Nurse,et al.  DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts. , 2000, The Biochemical journal.

[15]  A. Villeneuve,et al.  Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2. , 2001, Genes & development.

[16]  S. Elledge,et al.  Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[17]  L. Hartwell,et al.  Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. , 2001, Molecular cell.

[18]  A. Carr,et al.  A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins , 1999, Nature Cell Biology.

[19]  J. Hodgkin,et al.  MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans , 2000, Nature.

[20]  DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts. , 2000 .

[21]  D. Agard,et al.  The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis , 1993, The Journal of cell biology.

[22]  G. Roeder,et al.  Heteroduplex DNA formation and homolog pairing in yeast meiotic mutants. , 1995, Genetics.

[23]  G. Roeder.  Meiotic chromosomes: it takes two to tango. , 1997, Genes & development.

[24]  D. Thompson,et al.  Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. , 1999, Genetics.

[25]  T. Weinert,et al.  Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. , 1999, Genetics.

[26]  P. Zipperlen,et al.  Functional genomic analysis of C. elegans chromosome I by systematic RNA interference , 2000, Nature.

[27]  H. Okano,et al.  Critical Role of Caenorhabditis elegansHomologs of Cds1 (Chk2)-Related Kinases in Meiotic Recombination , 2001, Molecular and Cellular Biology.

[28]  A. Higashitani,et al.  Caenorhabditis elegans Chk2‐like gene is essential for meiosis but dispensable for DNA repair , 2000, FEBS letters.

[29]  S. Elledge,et al.  Asf1 links Rad53 to control of chromatin assembly. , 2001, Genes & development.

[30]  S. Elledge,et al.  DNA damage-induced activation of p53 by the checkpoint kinase Chk2. , 2000, Science.

[31]  Roeder Gs.  Meiotic chromosomes: it takes two to tango , 1997 .