Multicenter Research Study of the Relationship between Density of Resistant Isolates of Extended-Spectrum Beta-Lactamase Producing Bacteria and Density of Antibiotics Use in the KYUSYU-YAMAGUCHI Region

Hospital Abstract The detection rate of extended-spectrum beta-lactamase ( ESBL ) producing bacteria varies in diŠerent regions, so surveillance of the detection rate of ESBL producing bacteria in each region is beneˆcial for infectious disease treatment and infectious disease control. We conducted a multicenter research study on measures to promote the correct use of antimicrobial agents, by examining the detection rate of ESBL producing bacteria and the antimicrobial use density ( AUD ) at 29 facili-ties in the KYUSYU  YAMAGUCHI region. The formulation planning and the adoption of a notiˆ-cation system for carbapenem prescription were associated with a signiˆcant reduction in the AUD of carbapenems. However, this approach resulted in signiˆcant increase in the AUD of 3rd generation cephalosporins. There was no signiˆcant diŠerence in the detection rate of ESBL producing bacteria between regions. However, the detection rate of ESBL producing bacteria tended to be higher in Fukuoka prefecture compared to other region. There was no signiˆcant relationship between the AUD of antimicrobial agents, 4th generation cephalosporins and carbapenems, and the detection rate of ESBL producing bacteria. These results suggest that the spread of ESBL producing bacteria is connected to horizontal infection in hospitals and antimicrobial use for outpatients. Therefore, we think that combined measures should be undertaken to prevent the spread of ESBL