Nucleophilic Substitution Reactions on Chlorinated Thiophene Derivatives as Basis for the Synthesis of Thienoanellated O,N- and S,N-Heterocycles

The reactivity of 5-acetyl-2-chloro-3-nitrothiophene with amines, alcohols, thiols and bifunctional compounds, as well as reactions of methyl 5-chloro-4-nitro-2-thiophene-carboxylate with various hydrazides are described. These substitution reactions provide an easy access to thieno-anellated heterocycles