MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset.

[1]  I. Bozzoni,et al.  microRNAs Modulate Spatial Memory in the Hippocampus and in the Ventral Striatum in a Region-Specific Manner , 2016, Molecular Neurobiology.

[2]  Chaoqian Xu,et al.  MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction , 2016, Cellular Physiology and Biochemistry.

[3]  T. Baram,et al.  Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks. , 2016, Cell reports.

[4]  D. Johnston,et al.  Cell-Type Specific Channelopathies in the Prefrontal Cortex of the fmr1-/y Mouse Model of Fragile X Syndrome,, , 2015, eNeuro.

[5]  D. Bartel,et al.  Predicting effective microRNA target sites in mammalian mRNAs , 2015, eLife.

[6]  Z. Xu,et al.  Reduced expression of IA channels is associated with postischemic seizures in hyperglycemic rats , 2014, Journal of neuroscience research.

[7]  H. Fröhlich,et al.  Different MicroRNA Profiles in Chronic Epilepsy Versus Acute Seizure Mouse Models , 2014, Journal of Molecular Neuroscience.

[8]  S. Nelson,et al.  Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation. , 2014, Human molecular genetics.

[9]  D. Johnston,et al.  Loss of Functional A-Type Potassium Channels in the Dendrites of CA1 Pyramidal Neurons from a Mouse Model of Fragile X Syndrome , 2013, The Journal of Neuroscience.

[10]  J. Cuevas,et al.  MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators , 2013, PloS one.

[11]  J. Prehn,et al.  Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death , 2013, Cell Death and Disease.

[12]  S. D. Moore,et al.  The Auxiliary Subunit KChIP2 Is an Essential Regulator of Homeostatic Excitability* , 2013, The Journal of Biological Chemistry.

[13]  Donncha F. O’Brien,et al.  Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects , 2012, Nature Medicine.

[14]  A. Pasquinelli MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship , 2012, Nature Reviews Genetics.

[15]  Z. Xu,et al.  Alterations of A-type potassium channels in hippocampal neurons after traumatic brain injury. , 2012, Journal of neurotrauma.

[16]  Y. Jan,et al.  Bidirectional Regulation of Dendritic Voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein , 2011, Neuron.

[17]  R. Stallings,et al.  miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. , 2011, The American journal of pathology.

[18]  D. Hoffman,et al.  DPP6 Establishes the A-Type K+ Current Gradient Critical for the Regulation of Dendritic Excitability in CA1 Hippocampal Neurons , 2011, Neuron.

[19]  S. Warren,et al.  Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling. , 2011, Molecular cell.

[20]  Yan Cheng,et al.  Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/b , 2011, Brain Research.

[21]  A. Jeromin,et al.  Fragile X Mental Retardation Protein Regulates Protein Expression and mRNA Translation of the Potassium Channel Kv4.2 , 2011, The Journal of Neuroscience.

[22]  J. Neilson,et al.  Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 , 2010, Neuron.

[23]  R. Hrachovy,et al.  Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation , 2009, Epilepsia.

[24]  D. Bartel MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[25]  K. Rhodes,et al.  Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy , 2008, Neuroscience.

[26]  Sasha F. Levy,et al.  Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. , 2007, RNA.

[27]  Daniel Johnston,et al.  Deletion of Kv4.2 Gene Eliminates Dendritic A-Type K+ Current and Enhances Induction of Long-Term Potentiation in Hippocampal CA1 Pyramidal Neurons , 2006, The Journal of Neuroscience.

[28]  Kazumi Matsuda,et al.  A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy , 2006, Neurobiology of Disease.

[29]  J. Nerbonne,et al.  Targeted Deletion of Kv4.2 Eliminates Ito,f and Results in Electrical and Molecular Remodeling, With No Evidence of Ventricular Hypertrophy or Myocardial Dysfunction , 2005, Circulation research.

[30]  M. Covarrubias,et al.  Molecular physiology and modulation of somatodendritic A-type potassium channels , 2004, Molecular and Cellular Neuroscience.

[31]  D. Johnston,et al.  Acquired Dendritic Channelopathy in Temporal Lobe Epilepsy , 2004, Science.

[32]  Daniela C. Zarnescu,et al.  Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway , 2004, Nature Neuroscience.

[33]  Gary Ruvkun,et al.  Identification of many microRNAs that copurify with polyribosomes in mammalian neurons , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[34]  K. Rhodes,et al.  A Fundamental Role for KChIPs in Determining the Molecular Properties and Trafficking of Kv4.2 Potassium Channels* , 2003, Journal of Biological Chemistry.

[35]  J. Eubanks,et al.  Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat Kv4.2 potassium channel gene , 1997, Neuroscience Letters.

[36]  Y. Jan,et al.  Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures , 1992, Neuron.

[37]  D. Henshall,et al.  microRNA and Epilepsy. , 2015, Advances in experimental medicine and biology.

[38]  Sébastien A. Gauthier,et al.  In vitro assays measuring protection by proteins such as cystatin C of primary cortical neuronal and smooth muscle cells. , 2012, Methods in molecular biology.