Prevention of Breast Cancer (Part I): Epidemiology, Risk Factors, and Risk Assessment Tools

ABSTRACT Advances in breast cancer research have led to declining death rates from this disease because of early detection through mammographic screening and improved therapy for breast cancer. The concept that breast cancer, in some cases, can be prevented has been explored over the last three decades. This article, part I of a two-part series, will focus on the epidemiology, the risk factors associated with breast cancer, and the available risk assessment tools, which can help define who should be considered for risk reduction strategies. Part II will focus on discussing risk reduction strategies.

[1]  J. Cronin,et al.  Summary of the workshop , 1992 .

[2]  D. Albanes,et al.  Adiposity, adult weight change, and postmenopausal breast cancer risk. , 2006, Archives of internal medicine.

[3]  W D Flanders,et al.  The lifetime risk of developing breast cancer. , 1993, Journal of the National Cancer Institute.

[4]  J. Cerhan,et al.  Recreational physical activity and risk of postmenopausal breast cancer based on hormone receptor status. , 2006, Archives of internal medicine.

[5]  J. Manson,et al.  The Women’s Health Initiative Randomized Controlled Dietary Modification Trial , 2022 .

[6]  G. Colditz,et al.  Summary of the workshop , 1998, Cancer.

[7]  S. Haslam,et al.  Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. , 1998, Cancer research.

[8]  S. Yuasa,et al.  Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: Associations and interactions in an international case‐control study , 1990, International journal of cancer.

[9]  V Shane Pankratz,et al.  Benign breast disease and the risk of breast cancer. , 2005, The New England journal of medicine.

[10]  J. Manson,et al.  Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. , 2008, Archives of internal medicine.

[11]  R. Hiatt,et al.  Calcium plus vitamin D supplementation and the risk of breast cancer. , 2008, Journal of the National Cancer Institute.

[12]  J. López-Sáez,et al.  Selenium in Breast Cancer , 2003, Oncology.

[13]  R. Goldbohm,et al.  Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease , 2001, The Lancet.

[14]  B. Friedenson Oral contraceptives and the risk of breast cancer. , 2002, The New England journal of medicine.

[15]  H A Risch,et al.  The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions , 2008, British Journal of Cancer.

[16]  Bingshu E. Chen,et al.  Breast cancer mortality trends in the United States according to estrogen receptor status and age at diagnosis. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  Eric J Feuer,et al.  The decrease in breast-cancer incidence in 2003 in the United States. , 2007, The New England journal of medicine.

[18]  J. Manson,et al.  Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. , 2008, JAMA.

[19]  D. Berry,et al.  Effect of screening and adjuvant therapy on mortality from breast cancer , 2005 .

[20]  G. Noël,et al.  [Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomized controlled trial]. , 1999, Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique.

[21]  J Chang-Claude,et al.  Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. , 1998, American journal of human genetics.

[22]  C. Ulrich,et al.  Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. , 2004, Cancer research.

[23]  R. Krauss Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial , 2006, Current atherosclerosis reports.

[24]  A. Jemal,et al.  Cancer Statistics, 2008 , 2008, CA: a cancer journal for clinicians.

[25]  J. Manson,et al.  Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. , 2006, JAMA.

[26]  J. Manson,et al.  Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. , 1999, Journal of the National Cancer Institute.

[27]  Yikyung Park,et al.  Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study. , 2009, American journal of epidemiology.

[28]  Victor Kipnis,et al.  Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health-AARP Diet and Health Study cohort. , 2007, Journal of the National Cancer Institute.

[29]  C. Perou,et al.  Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. , 2006, JAMA.

[30]  M H Gail,et al.  Validating and improving models for projecting the absolute risk of breast cancer. , 2001, Journal of the National Cancer Institute.

[31]  D. Zava,et al.  Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. , 1997, Nutrition and cancer.

[32]  L. Jones,et al.  Impact of breast cancer on African American women: priority areas for research in the next decade. , 2002, American journal of public health.

[33]  W. Willett,et al.  Adult weight change and risk of postmenopausal breast cancer. , 2006, JAMA.

[34]  Loki Natarajan,et al.  Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial. , 2007, JAMA.

[35]  M. Thun,et al.  Recreational physical activity and risk of postmenopausal breast cancer in a large cohort of US women , 2003, Cancer Causes & Control.

[36]  Julian Peto,et al.  Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies , 1996, The Lancet.

[37]  Christine A Erdmann,et al.  Radiation and breast cancer: a review of current evidence , 2004, Breast Cancer Research.

[38]  R. A. Johnson,et al.  Data on Prior Pesticide Use Collected from Self‐and Proxy Respondents , 1993, Epidemiology.

[39]  Jean-Philippe Antignac,et al.  Global gene expression profiles induced by phytoestrogens in human breast cancer cells. , 2008, Endocrine-related cancer.

[40]  R. Vierkant,et al.  Stratification of breast cancer risk in women with atypia: a Mayo cohort study. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  John Robbins,et al.  National cross sectional survey to determine whether the decision to delivery interval is critical in emergency caesarean section , 2004, BMJ : British Medical Journal.

[42]  J. Kelsey,et al.  Exogenous estrogens and other factors in the epidemiology of breast cancer. , 1981, Journal of the National Cancer Institute.

[43]  T. Sellers,et al.  Intake of vitamins A, C, and E and postmenopausal breast cancer. The Iowa Women's Health Study. , 1996, American journal of epidemiology.

[44]  W. Willett,et al.  A prospective study of age-specific physical activity and premenopausal breast cancer. , 2008, Journal of the National Cancer Institute.

[45]  N. Cook,et al.  Lifetime physical activity and risk of breast cancer , 2001, British Journal of Cancer.

[46]  R. Elledge,et al.  Premalignant and In Situ Breast Disease: Biology and Clinical Implications , 2005, Annals of Internal Medicine.

[47]  J. Manson,et al.  Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. , 2006, JAMA.

[48]  V. Beral,et al.  Passive smoking and breast cancer in never smokers: prospective study and meta-analysis. , 2008, International journal of epidemiology.

[49]  J. Manson,et al.  Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial , 2005, JAMA.

[50]  J. Manson,et al.  Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. , 2009, Journal of the National Cancer Institute.

[51]  James Dignam,et al.  Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial , 1999, The Lancet.

[52]  K. Robien,et al.  the Iowa Women's Health Study , 2008 .

[53]  C. Kooperberg,et al.  Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study. , 2003, JAMA.

[54]  J. Berlin,et al.  Lifetime recreational exercise activity and breast cancer risk among black women and white women. , 2005, Journal of the National Cancer Institute.

[55]  M. Pike,et al.  Epidemiology of soy exposures and breast cancer risk , 2008, British Journal of Cancer.

[56]  J. Manson,et al.  β-Carotene Supplementation and Incidence of Cancer and Cardiovascular Disease: the Women's Health Study. , 1999, Journal of the National Cancer Institute.

[57]  Giovanni Parmigiani,et al.  BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[58]  J. Corton,et al.  Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. , 1998, Endocrinology.

[59]  Cathy J Bradley,et al.  Race, socioeconomic status, and breast cancer treatment and survival. , 2002, Journal of the National Cancer Institute.

[60]  J R Marshall,et al.  Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. , 2000, American journal of epidemiology.

[61]  L. Robison,et al.  Breast Cancer after Childhood Cancer: A Report from the Childhood Cancer Survivor Study , 2004, Annals of Internal Medicine.

[62]  B. Arun,et al.  Genetic Predisposition to Breast Cancer and Genetic Counseling and Testing , 2008 .

[63]  W. Willett,et al.  Intake of dairy products, calcium, and vitamin d and risk of breast cancer. , 2002, Journal of the National Cancer Institute.

[64]  D. Hunter,et al.  Coffee, tea, caffeine and risk of breast cancer: A 22‐year follow‐up , 2008, International journal of cancer.

[65]  Julian Peto,et al.  Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Collaborative Group on Hormonal Factors in Breast Cancer , 1996 .

[66]  Melissa Bondy,et al.  Projecting individualized absolute invasive breast cancer risk in African American women. , 2007, Journal of the National Cancer Institute.

[67]  R. Hoover,et al.  Menstrual factors and risk of breast cancer. , 1988, Cancer investigation.

[68]  W. Willett,et al.  Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. , 2002, International journal of epidemiology.

[69]  R. Langer,et al.  Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. , 2003, JAMA.

[70]  J L Kelsey,et al.  Radiation and other environmental exposures and breast cancer. , 1993, Epidemiologic reviews.

[71]  J. Corton,et al.  Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β. , 1998, Endocrinology.

[72]  N Risch,et al.  Autosomal dominant inheritance of early‐onset breast cancer. Implications for risk prediction , 1994, Cancer.

[73]  J. Manson,et al.  Use of a dummy (pacifier) during sleep and risk of sudden infant death syndrome (SIDS): population based case-control study , 2005, BMJ : British Medical Journal.

[74]  Ames,et al.  Cohort studies of fat intake and the risk of breast cancer--a pooled analysis. , 2000 .

[75]  Physical activity and the risk of breast cancer. , 1997, The New England journal of medicine.