Lidocaine-Induced Seizures after Intraurethral Instillation: A Case Report

Lidocaine is commonly used to facilitate catheterization and cystoscopy in urology. Lidocaine, when used for topical anesthesia, has mild side effects such as disorientation, drowsiness, perioral numbness, muscle twitching, vertigo, and tinnitus occasionally. However, its severe side effects, such as hypersensitivity, seizures, respiratory depression, and arrhythmia, are rare with topical use. Only 1 published report about seizures after urethral instillation was found. We report on 2 cases with lidocaine-induced seizures after intraurethral instillation and review the related literature to analyze the risk factors.