Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.

[1]  Thomas M. Wasylenko,et al.  Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells , 2013, Nature Communications.

[2]  E. White,et al.  Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids , 2013, Proceedings of the National Academy of Sciences.

[3]  G. Stephanopoulos,et al.  Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle*♦ , 2013, The Journal of Biological Chemistry.

[4]  John M. Asara,et al.  Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.

[5]  G. Stephanopoulos,et al.  In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. , 2013, Cell metabolism.

[6]  A. Lane,et al.  Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. , 2012, Cell metabolism.

[7]  F. Khuri,et al.  Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. , 2011, Molecular cell.

[8]  Jesse M. Platt,et al.  Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability , 2011, Proceedings of the National Academy of Sciences.

[9]  Christian M. Metallo,et al.  Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia , 2011, Nature.

[10]  W. Marston Linehan,et al.  Reductive carboxylation supports growth in tumor cells with defective mitochondria , 2011, Nature.

[11]  C. Thompson,et al.  Glutamine addiction: a new therapeutic target in cancer. , 2010, Trends in biochemical sciences.

[12]  M. Brand,et al.  Degradation of an intramitochondrial protein by the cytosolic proteasome , 2010, Journal of Cell Science.

[13]  A. G. de Herreros,et al.  The Hypoxia-controlled FBXL14 Ubiquitin Ligase Targets SNAIL1 for Proteasome Degradation* , 2009, The Journal of Biological Chemistry.

[14]  Z. Ronai,et al.  Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis , 2009, Pigment cell & melanoma research.

[15]  J. Mendell,et al.  Abstract #LB-186: c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2009 .

[16]  Z. Ronai,et al.  The Ubiquitin Ligase Siah2 and the Hypoxia Response , 2009, Molecular Cancer Research.

[17]  Anthony Mancuso,et al.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction , 2008, Proceedings of the National Academy of Sciences.

[18]  D. Bowtell,et al.  The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways , 2008, Proceedings of the National Academy of Sciences.

[19]  N. Denko,et al.  Hypoxia, HIF1 and glucose metabolism in the solid tumour , 2008, Nature Reviews Cancer.

[20]  Robert A. Harris,et al.  Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells* , 2008, Journal of Biological Chemistry.

[21]  G. Semenza,et al.  HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. , 2006, Cell metabolism.

[22]  N. Denko,et al.  HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. , 2006, Cell metabolism.

[23]  F. Kaper,et al.  Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. , 2005, Cancer research.

[24]  D. Bowtell,et al.  Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia , 2004, Cell.

[25]  M. Leonard,et al.  Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Mulchand S Patel,et al.  Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases , 2001, Experimental & Molecular Medicine.

[27]  Michael I. Wilson,et al.  C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.

[28]  Gary Fiskum,et al.  Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation , 1995, Molecular and Cellular Biochemistry.

[29]  R. Harris,et al.  Mammalian α‐keto acid dehydrogenase complexes: gene regulation and genetic defects 1 , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  D. Bowtell,et al.  Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. , 2004, The Journal of biological chemistry.