Lack of response to family selection for directional asymmetry in Drosophila melanogaster: left and right are not distinguished in development

Family selection for directional asymmetry in the expression of the Drosophila melanogaster mutant scute had no result. Fluctuating asymmetry did not show a selection differential correlated with directional asymmetry. The unfolding of bilateral symmetry in embryogenesis can be used to explain the lack of genetic variation for directional asymmetry. Directional asymmetry provides a well-understood example of a developmental constraint in evolution. It is proposed that as no evidence is available for an independent left-right gradient in the embryo, quantitative traits can only be expressed variably along an existing gradient of positional information or a morphogen.

[1]  D. Falconer,et al.  Introduction to Quantitative Genetics. , 1961 .

[2]  W. Scharloo,et al.  Selection on Morphological Patterns , 1988 .

[3]  F. Allendorf,et al.  Fluctuating asymmetry as an indicator of stress: Implications for conservation biology. , 1989, Trends in ecology & evolution.

[4]  J. Rendel,et al.  CANALIZATION OF THE SCUTE PHENOTYPE OF DROSOPHILA , 1959 .

[5]  G. Morata,et al.  Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila. , 1976, Developmental biology.

[6]  Hilla Peretz,et al.  Ju n 20 03 Schrödinger ’ s Cat : The rules of engagement , 2003 .

[7]  K. Anderson,et al.  Establishment of dorsal-ventral polarity in the drosophila embryo: The induction of polarity by the Toll gene product , 1985, Cell.

[8]  J A Coyne.  Lack of response to selection for directional asymmetry in Drosophila melanogaster. , 1987, The Journal of heredity.

[9]  M. Akam,et al.  The molecular basis for metameric pattern in the Drosophila embryo. , 1987, Development.

[10]  W. Janning.  Gynandromorph fate maps in Drosophila. , 1978, Results and problems in cell differentiation.

[11]  A. Garcı́a-Bellido,et al.  Genetic Analysis of the Achaete-Scute System of DROSOPHILA MELANOGASTER. , 1979, Genetics.

[12]  B. Nagorcka.  A pattern formation mechanism to control spatial organization in the embryo of Drosophila melanogaster. , 1988, Journal of theoretical biology.

[13]  T. Dobzhansky,et al.  An experiment on migration and simultaneous selection for several traits in Drosophila pseudoobscura. , 1967, Genetics.

[14]  T. Schüpbach,et al.  The egg came first, of course! Anterior-posterior pattern formation in Drosophila embryogenesis and oogenesis. , 1989, Trends in genetics : TIG.

[15]  C. Nüsslein-Volhard,et al.  Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid , 1986, Nature.

[16]  A. Sturtevant.  INHERITANCE OF DIRECTION OF COILLING IN LIMNAEA. , 1923, Science.

[17]  Thomas C. Kaufman,et al.  Embryos, genes, and evolution: The developmental-genetic basis of evolutionary change , 1983 .

[18]  J. M. Smith,et al.  The Genetics of a Pattern. , 1960, Genetics.

[19]  A. El-Tantawy.  Studies in quantitative inheritance in Drosophila , 1965 .

[20]  G. Struhl,et al.  A molecular gradient in early Drosophila embryos and its role in specifying the body pattern , 1986, Nature.

[21]  H. B. Parks.  Cleavage Patterns in Drosophila and Mosaic Formation , 1936 .

[22]  B. Nagorcka,et al.  Wavelike isomorphic prepatterns in development. , 1989, Journal of theoretical biology.

[23]  K. Anderson.  Dorsal—ventral embryonic pattern genes of Drosophila , 1987 .