The signalling conformation of the insulin receptor ectodomain
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C. Müller | J. Menting | T. Langer | M. Lawrence | M. Dreyer | N. Tennagels | F. Weis | P. Wohlfart | M. Margetts | S. J. Chan | Yibin Xu
[1] J. Menting,et al. How ligand binds to the type 1 insulin-like growth factor receptor , 2018, Nature Communications.
[2] Bridget Carragher,et al. Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis , 2018, Nature.
[3] T. Walz,et al. Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor , 2017, bioRxiv.
[4] D. Agard,et al. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy , 2017, Nature Methods.
[5] N. Tennagels,et al. Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function , 2016, Cardiovascular Diabetology.
[6] E. Lindahl,et al. Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2 , 2016, bioRxiv.
[7] Brian J. Smith,et al. Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor* , 2016, The Journal of Biological Chemistry.
[8] Brian J. Smith,et al. Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain. , 2016, Structure.
[9] Guanghui Yang,et al. Sampling the conformational space of the catalytic subunit of human γ-secretase , 2015, bioRxiv.
[10] Kai Zhang,et al. Gctf: Real-time CTF determination and correction , 2015, bioRxiv.
[11] S. Hubbard,et al. The insulin and IGF1 receptor kinase domains are functional dimers in the activated state , 2015, Nature Communications.
[12] Sjors H.W. Scheres,et al. Semi-automated selection of cryo-EM particles in RELION-1.3 , 2015, Journal of structural biology.
[13] P. D. Meyts,et al. Insulin/receptor binding: The last piece of the puzzle? , 2015 .
[14] M. Lawrence,et al. Structural Features of the Receptor Tyrosine Kinase Ectodomains , 2015 .
[15] Yosef Yarden,et al. Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease , 2015, Springer New York.
[16] D. Shaw,et al. How IGF-1 activates its receptor , 2014, eLife.
[17] Brian J. Smith,et al. Protective hinge in insulin opens to enable its receptor engagement , 2014, Proceedings of the National Academy of Sciences.
[18] R. Henderson,et al. High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy☆ , 2013, Ultramicroscopy.
[19] Andrzej M. Brzozowski,et al. How insulin engages its primary binding site on the insulin receptor , 2013, Nature.
[20] Sjors H.W. Scheres,et al. RELION: Implementation of a Bayesian approach to cryo-EM structure determination , 2012, Journal of structural biology.
[21] Shaoxia Chen,et al. Prevention of overfitting in cryo-EM structure determination , 2012, Nature Methods.
[22] B. Hansen,et al. Systematic Evaluation of the Metabolic to Mitogenic Potency Ratio for B10-Substituted Insulin Analogues , 2012, PloS one.
[23] Sjors H.W. Scheres,et al. A Bayesian View on Cryo-EM Structure Determination , 2012, 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI).
[24] Sharon R Grossman,et al. Integrating common and rare genetic variation in diverse human populations , 2010, Nature.
[25] Brian J. Smith,et al. Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists , 2010, Proceedings of the National Academy of Sciences.
[26] Randy J. Read,et al. Acta Crystallographica Section D Biological , 2003 .
[27] M. Lawrence,et al. N‐linked glycans of the human insulin receptor and their distribution over the crystal structure , 2008, Proteins.
[28] K. Siddle,et al. An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors* , 2008, Journal of Biological Chemistry.
[29] M. Lawrence,et al. Structure of the insulin receptor ectodomain reveals a folded-over conformation , 2006, Nature.
[30] David N Mastronarde,et al. Automated electron microscope tomography using robust prediction of specimen movements. , 2005, Journal of structural biology.
[31] Kevin Cowtan,et al. research papers Acta Crystallographica Section D Biological , 2005 .
[32] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[33] R. Henderson,et al. Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy. , 2003, Journal of molecular biology.
[34] J. Whittaker,et al. Structural biology of insulin and IGF1 receptors: implications for drug design , 2002, Nature Reviews Drug Discovery.
[35] N. Mckern,et al. High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper , 2000, FEBS letters.
[36] N. Mckern,et al. Crystallization of the first three domains of the human insulin‐like growth factor‐1 receptor , 1997, Protein science : a publication of the Protein Society.
[37] N. Mckern,et al. The Disulfide Bonds in the C-terminal Domains of the Human Insulin Receptor Ectodomain* , 1997, The Journal of Biological Chemistry.
[38] L. Cavaleri,et al. Purification and properties of insulin receptor ectodomain from large-scale mammalian cell culture. , 1995, Protein expression and purification.
[39] L. Schäffer. A model for insulin binding to the insulin receptor. , 1994, European journal of biochemistry.
[40] P. S. Kim,et al. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. , 1991, Science.
[41] L. Schäffer,et al. Immobilized insulin for high capacity affinity chromatography of insulin receptors. , 1991, The Journal of biological chemistry.
[42] J. Brange,et al. Monomeric insulins obtained by protein engineering and their medical implications , 1988, Nature.
[43] K. Siddle,et al. Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor. , 1987, The Biochemical journal.
[44] K. Siddle,et al. Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor. , 1986, The Biochemical journal.
[45] K. Jarnagin,et al. The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling , 1985, Cell.
[46] D. Neville,et al. Insulin interactions with its receptors: experimental evidence for negative cooperativity. , 1973, Biochemical and biophysical research communications.