Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.
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S. Green | Rebecca P A Ellston | B. Barlaam | R. Morgentin | S. Cosulich | Urs J Hancox | U. Polanska | K. Hudson | Linette Ruston | K. Page | G. Ouvry | Honorine Lebraud | M. Fitzek | Lara Ward | C. Harris | C. Lambert-van der Brempt | Bénédicte Delouvrié | G. Pasquet | Twana Saleh | Hervé Germain | M. Vautier | F. Magnien | Antoine Le Griffon | M. Lamorlette | Rebecca Ellston