Affinity for self antigen selects regulatory T cells with distinct functional properties

[1]  T. Chatila,et al.  Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis , 2016, The Journal of Immunology.

[2]  K. S. Kim,et al.  Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine , 2016, Science.

[3]  G. Anderson,et al.  CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3+ T Cells , 2016, Cell reports.

[4]  M. Riese,et al.  Regulatory T Cells Require TCR Signaling for Their Suppressive Function , 2015, The Journal of Immunology.

[5]  Yi Shi,et al.  TCRklass: A New K-String–Based Algorithm for Human and Mouse TCR Repertoire Characterization , 2015, The Journal of Immunology.

[6]  E. Palmer,et al.  Optimal T-cell receptor affinity for inducing autoimmunity , 2014, Proceedings of the National Academy of Sciences.

[7]  Shirley L. Zhang,et al.  Both retention and recirculation contribute to long‐lived regulatory T‐cell accumulation in the thymus , 2014, European journal of immunology.

[8]  D. Campbell,et al.  CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets , 2014, The Journal of experimental medicine.

[9]  F. Powrie,et al.  Regulatory T cells and immune tolerance in the intestine. , 2013, Cold Spring Harbor perspectives in biology.

[10]  J. Bluestone,et al.  Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity , 2013, Front. Immunol..

[11]  L. Chatenoud,et al.  Faculty Opinions recommendation of Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. , 2013 .

[12]  S. Sakaguchi,et al.  Development and maintenance of regulatory T cells. , 2013, Immunity.

[13]  Judith N. Mandl,et al.  T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. , 2013, Immunity.

[14]  C. Govern,et al.  Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection , 2012, Proceedings of the National Academy of Sciences.

[15]  J. Weiss,et al.  Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells , 2012, The Journal of experimental medicine.

[16]  Daniel J. Kuster,et al.  Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo , 2012, The Journal of experimental medicine.

[17]  L. Klein,et al.  Regulatory T cell differentiation: turning harmful into useful. , 2012, Immunity.

[18]  C. Hsieh,et al.  A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. , 2012, Immunity.

[19]  A. Rudensky,et al.  Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict , 2012, Cell.

[20]  S. Ju,et al.  A novel function of IL-2: chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation. , 2012, Journal of autoimmunity.

[21]  P. Ricciardi-Castagnoli,et al.  Interleukin-2 Production by Dendritic Cells and its Immuno-Regulatory Functions , 2012, Front. Immun..

[22]  A. Rudensky,et al.  Regulatory T cells: mechanisms of differentiation and function. , 2012, Annual review of immunology.

[23]  L. Stern,et al.  A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands. , 2011, Immunity.

[24]  T. Chatila,et al.  A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. , 2011, Immunity.

[25]  E. Shevach,et al.  A Self-Reactive TCR Drives the Development of Foxp3+ Regulatory T Cells That Prevent Autoimmune Disease , 2011, The Journal of Immunology.

[26]  Nicole R. Cunningham,et al.  T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse , 2011, The Journal of experimental medicine.

[27]  S. Mazmanian,et al.  Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota , 2010, Proceedings of the National Academy of Sciences.

[28]  Y. Belkaid,et al.  Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells , 2010, The Journal of Immunology.

[29]  A. Rudensky,et al.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate , 2010, Nature.

[30]  R. Podolsky,et al.  Foxp3-Deficient Regulatory T Cells Do Not Revert into Conventional Effector CD4+ T Cells but Constitute a Unique Cell Subset12 , 2009, The Journal of Immunology.

[31]  T. Nomura,et al.  Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. , 2009, Immunity.

[32]  A. Rudensky,et al.  In Vivo Analysis of Dendritic Cell Development and Homeostasis , 2009, Science.

[33]  G. Anderson,et al.  Reaggregate thymus cultures. , 2008, Journal of visualized experiments : JoVE.

[34]  P. Perrin,et al.  Th2 Lymphoproliferative Disorder of LatY136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells1 , 2008, The Journal of Immunology.

[35]  Nagendra Singh,et al.  Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. , 2007, Immunity.

[36]  A. Thomson,et al.  Tolerogenic dendritic cells and the quest for transplant tolerance , 2007, Nature Reviews Immunology.

[37]  T. Chatila,et al.  Regulatory T cell development in the absence of functional Foxp3 , 2007, Nature Immunology.

[38]  A. Rudensky,et al.  Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice , 2007, Nature Immunology.

[39]  M. Bevan,et al.  T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. , 2006, Immunity.

[40]  L. Ignatowicz,et al.  Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. , 2006, Immunity.

[41]  Bernhard Moser,et al.  On the T , 2006, Fuzzy Sets Syst..

[42]  Michael Loran Dustin,et al.  Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo , 2006, The Journal of experimental medicine.

[43]  A. Rudensky,et al.  An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires , 2006, Nature Immunology.

[44]  T. Chatila,et al.  Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. , 2005, The Journal of allergy and clinical immunology.

[45]  Clemencia Pinilla,et al.  How the T Cell Repertoire Becomes Peptide and MHC Specific , 2005, Cell.

[46]  T. Phelps,et al.  Estimates of Biogenic Methane Production Rates in Deep Marine Sediments at Hydrate Ridge, Cascadia Margin , 2004, Applied and Environmental Microbiology.

[47]  A. Rudensky,et al.  Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. , 2004, Immunity.

[48]  J. Buer,et al.  Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells , 2004, The Journal of experimental medicine.

[49]  Li Li,et al.  Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.

[50]  F. Powrie,et al.  Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells1 , 2003, The Journal of Immunology.

[51]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[52]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[53]  L. Klein,et al.  Origin of regulatory T cells with known specificity for antigen , 2002, Nature Immunology.

[54]  A. Naji,et al.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[55]  W. Heath,et al.  Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements , 1998, Immunology and cell biology.

[56]  C. Kurts,et al.  CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity , 1997, The Journal of experimental medicine.

[57]  K. Rajewsky,et al.  Critical role for β7 integrins in formation of the gut-associated lymphoid tissue , 1996, Nature.

[58]  B. Malissen,et al.  Altered T cell development in mice with a targeted mutation of the CD3‐epsilon gene. , 1995, The EMBO journal.

[59]  Sharon K. Ahluwalia,et al.  Peripheral Education of the Immune System by Colonic Commensal Microbiota , 2012 .

[60]  Sang Joon Kim,et al.  A Mathematical Theory of Communication , 2006 .

[61]  Ray H. Baughman,et al.  Supporting Online Material , 2003 .

[62]  H. Ochs,et al.  The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 , 2001, Nature Genetics.

[63]  W. Bossert,et al.  The Measurement of Diversity , 2001 .

[64]  K. Rajewsky,et al.  Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. , 1996, Nature.