Epidural caesarean section in a patient with congenital antithrombin III deficiency.

Congenital antithrombin III (AT-Ill) deficiency is an inherited autosomal dominant condition with a prevalence of 1 in 2,000 to 20,000. Affected individuals are predisposed to venous thromboembolism which is commonly precipitated by pregnancy, surgery or infection'. Untreated, AT-Ill deficiency in pregnancy is associated with an extremely high risk of thrombosis (700/0)2. The various regimens of antithrombosis prophylaxis for AT-Ill deficiency in pregnancy have implications for the provision of anaesthesia and regional analgesia.

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