International Commission for Protection Against Environmental Mutagens and Carcinogens. Power frequency electric and magnetic fields: a review of genetic toxicology.

Epidemiologic studies have reported a modestly increased risk of childhood leukemia associated with certain electric power wire configurations. Since cancer likely involves DNA damage, this review discusses the evidence of direct and indirect genetic toxicity effects for both electric and magnetic fields at 50- and 60-Hz and miscellaneous pulsed exposures. Exposure conditions vary greatly among different end points measured, making comparisons and conclusions among experiments difficult. Although most of the available evidence does not suggest that electric and/or magnetic fields cause DNA damage, the existence of some positive findings and limitations in the set of studies carried out suggest a need for additional work.

[1]  M. Miller,et al.  A cytohistological analysis of roots whose growth is affected by a 60-Hz electric field. , 1985, Bioelectromagnetics.

[2]  D C Thomas,et al.  Exposure to residential electric and magnetic fields and risk of childhood leukemia. , 1991, American journal of epidemiology.

[3]  P. Perry Chemical Mutagens and Sister-Chromatid Exchange , 1980 .

[4]  A. Pilla,et al.  Electromagnetic fields induced by Helmholtz aiding coils inside saline-filled boundaries. , 1983, Bioelectromagnetics.

[5]  J. A. Reese,et al.  Exposure of mammalian cells to 60-Hz magnetic or electric fields: analysis of DNA repair of induced, single-strand breaks. , 1990, Bioelectromagnetics.

[6]  O. Gandhi,et al.  Reproductive integrity of mammalian cells exposed to power frequency electromagnetic fields , 1991, Environmental and molecular mutagenesis.

[7]  Morton W. Miller,et al.  Lack of effect of extremely low frequency electric and magnetic fields on roots of Vicia faba , 1976 .

[8]  H. J. Evans,et al.  Cytological Methods for Detecting Chemical Mutagens , 1976 .

[9]  B. Greenebaum,et al.  Low-voltage ELF electric field measurements in ionic media. , 1985, Bioelectromagnetics.

[10]  J. M. García-Sagredo,et al.  Effect on SCE in Human chromosomes in vitro of low‐level pulsed magnetic field , 1990, Environmental and molecular mutagenesis.

[11]  Morton W. Miller,et al.  Inhibition and recovery of growth processes in roots of Pisum sativum L. exposed to 60-Hz electric fields. , 1981, Bioelectromagnetics.

[12]  K. H. Mild,et al.  Chromosomal effects in lymphocytes of 400 kV-substation workers , 1988, Radiation and environmental biophysics.

[13]  R D Phillips,et al.  Comparison of the coupling of grounded humans, swine and rats to vertical, 60-Hz electric fields. , 1980, Bioelectromagnetics.

[14]  M. T. Marron,et al.  Bioeffects of extremely low-frequency electromagnetic fields. Variation with intensity, waveform, and individual or combined electric and magnetic fields. , 1979, Radiation research.

[15]  R L Moore,et al.  Biological effects of magnetic fields: studies with microorganisms. , 1979, Canadian journal of microbiology.

[16]  N. Wertheimer,et al.  Electrical wiring configurations and childhood cancer. , 1979, American journal of epidemiology.

[17]  W Qassem,et al.  Cytogenetic effects of pulsing electromagnetic field on human lymphocytes in vitro: chromosome aberrations, sister-chromatid exchanges and cell kinetics. , 1991, Mutation research.

[18]  W. Schmid The Micronucleus Test for Cytogenetic Analysis , 1976 .

[19]  J. A. Reese,et al.  Exposure of mammalian cells to 60-Hz magnetic or electric fields: analysis for DNA single-strand breaks. , 1988, Bioelectromagnetics.

[20]  G. Obe,et al.  Effects of 50-hertz electromagnetic fields on proliferation and on chromosomal alterations in human peripheral lymphocytes untreated or pretreated with chemical mutagens. , 1989, Mutation research.

[21]  F. Serres CHEMICAL MUTAGENS: PRINCIPLES AND METHODS FOR THEIR DETECTION , 1972 .

[22]  H. Wachtel,et al.  Case-control study of childhood cancer and exposure to 60-Hz magnetic fields. , 1988, American journal of epidemiology.

[23]  T. Tenforde,et al.  Interaction of extremely low frequency electric and magnetic fields with humans. , 1987, Health physics.

[24]  R Hauf,et al.  Analysis of structural chromosome changes and SCE after occupational long-term exposure to electric and magnetic fields from 380 kV-systems , 1981, Radiation and environmental biophysics.

[25]  G Castellani,et al.  Spontaneous and mitomycin-C-induced micronuclei in human lymphocytes exposed to extremely low frequency pulsed magnetic fields. , 1991, Biochemical and biophysical research communications.

[26]  J. Samuel,et al.  Viabilities and mutation frequencies of CHO-K1 cells following exposure to 60-Hz electric fields , 1985 .

[27]  J. Juutilainen,et al.  Mutation frequency in Salmonella exposed to weak 100-Hz magnetic fields. , 2008, Hereditas.

[28]  M M Cohen,et al.  Effect of low-level, 60-Hz electromagnetic fields on human lymphoid cells: I. Mitotic rate and chromosome breakage in human peripheral lymphocytes. , 1986, Bioelectromagnetics.

[29]  M M Cohen,et al.  The effect of low-level 60-Hz electromagnetic fields on human lymphoid cells. II. Sister-chromatid exchanges in peripheral lymphocytes and lymphoblastoid cell lines. , 1986, Mutation research.

[30]  R. Saunders,et al.  Dominant lethal studies in male mice after exposure to a 50-Hz electric field. , 1990, Bioelectromagnetics.

[31]  G. Rodan,et al.  DNA synthesis in cartilage cells is stimulated by oscillating electric fields. , 1978, Science.

[32]  Antonio Scaglione,et al.  Chromosomal Aberrations Induced by Elf Electric Fields , 1985 .

[33]  S. Nordström,et al.  Clastogenic effects in human lymphocytes of power frequency electric fields: In vivo and in vitro studies , 1984, Radiation and environmental biophysics.

[34]  D A Savitz,et al.  Methodological issues in the epidemiology of electromagnetic fields and cancer. , 1989, Epidemiologic reviews.

[35]  W. Kaune,et al.  Residential magnetic and electric fields. , 1987, Bioelectromagnetics.

[36]  S. E. El Nahas,et al.  Micronuclei formation in somatic cells of mice exposed to 50‐Hz electric fields , 1989, Environmental and molecular mutagenesis.

[37]  A. Liboff,et al.  Time-varying magnetic fields: effect on DNA synthesis. , 1984, Science.

[38]  M. Miller,et al.  Growth rate and mitotic index analysis of Vicia faba L. roots exposed to 60-Hz electric fields. , 1985, Bioelectromagnetics.

[39]  R. Greene 60 Hz ultra-high voltage electric field effect on onion root mitotic index: A lack of impact , 1983 .

[40]  W. Carrier,et al.  Effects of Extremely Low Frequency (Elf) Electric Fields On Cell Growth and Dna Repair In Human Skin Fibroblasts , 1986, Cell and tissue kinetics.