Unilateral Livedoid Vasculopathy Associated With Involutional Phase of Cutaneous Infantile Hemangioma

Livedoid vasculopathy is a bilateral painful and recurrent cutaneous ulcerative disorder of the legs that leads to atrophie blanche, atrophic white-porcelain scars, and is associated with disorders of fibrinolysis and/or coagulation. We present a young boy with an association between livedoid vasculopathy in the area of a previous involuted cutaneous hemangioma. We found 4 uncommon abnormalities associated with thrombo-occlusive events: heterozygous 20210 A→G genotype of prothrombin, reduced activity of anticoagulation proteins C and S, and elevated lipoprotein (a).

[1]  J. Kujovich.  Prothrombin-Related Thrombophilia , 2014 .

[2]  R. Vasconcelos,et al.  Livedoid vasculopathy secondary to high levels of lipoprotein(a) , 2011, The British journal of dermatology.

[3]  M. Sotto,et al.  Livedoid vasculopathy as a coagulation disorder. , 2011, Autoimmunity reviews.

[4]  M. Steinhoff,et al.  Livedoid vasculopathy in a pediatric patient with elevated lipoprotein(a) levels: prompt response to continuous low-molecular-weight heparin. , 2010, Archives of dermatology.

[5]  P. Saxena,et al.  Protein S deficiency: Recurrent ischemic stroke in young , 2009, Annals of Indian Academy of Neurology.

[6]  D. Hagler,et al.  Acute myocardial infarction in a child: possible pathogenic role of patent foramen ovale associated with heritable thrombophilia. , 2004, Pediatrics.

[7]  A. Boyvat,et al.  Livedoid vasculopathy associated with heterozygous protein C deficiency , 2000, The British journal of dermatology.

[8]  D. Adams,et al.  Vascular malformations and hemangiomas: a practical approach in a multidisciplinary clinic. , 2000, AJR. American journal of roentgenology.

[9]  P. Reitsma,et al.  Geographic Distribution of the 20210 G to A Prothrombin Variant , 1998, Thrombosis and Haemostasis.

[10]  P. Simioni,et al.  Heterozygous Protein C Deficiency Associated with Multiple Congenital Hemangiomas—A Case Report , 1991, Angiology.

[11]  J. HsiehWu.  Lipoprotein(a) in vascular disease, cancer and longevity. , 2011 .

[12]  E. Baskın,et al.  Recurrent Vasculopathic Skin Lesions Associated with Homozygous Protein C Deficiency , 2007, Pediatric dermatology.

[13]  F R Rosendaal,et al.  Risk of Myocardial Infarction Associated With Factor V Leiden or Prothrombin Interaction of Coagulation Defects and Cardiovascular Risk Factors : Increased , 1998 .