Mathematical Model of the Rapidly Activating Delayed Rectifier Potassium Current IKr in Rabbit Sinoatrial Node

Role of IKr in Rabbit Sinoatrial Node. Introduction: A rapidly activating delayed rectifier potassium current (IKr) is known to have an important role in determining the properties of spontaneous pacing in enzymatically isolated rabbit sinoatrial node (SAN) cells. The functional characteristics of IKr are conferred by its dependence on time, voltage, and external potassium. The aim of this study was to develop a rigorous mathematical representation for IKr based on experimental findings and to investigate the role of IKr in the automaticity and intercellular communication of SAN cells.

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