Variation in the heritability of body mass index based on diverse twin studies: a systematic review

Over the past three decades, twin studies have shown variation in the heritability of obesity. This study examined the difference of body mass index (BMI) heritability (BMI‐H) by population characteristics, such as sex, age, time period of observation and average BMI, as well as by broad social‐environmental factors as indicated by country‐level gross domestic product (GDP) per capita and GDP growth rate.

[1]  M. King,et al.  Genetic influences on changes in body mass index: a longitudinal analysis of women twins. , 1997, Obesity research.

[2]  J. Kaprio,et al.  The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies , 2010, International Journal of Obesity.

[3]  Jennifer R Harris,et al.  Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. , 2003, Twin research : the official journal of the International Society for Twin Studies.

[4]  J. Kaprio,et al.  Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men , 2008, Genetic epidemiology.

[5]  A. Rissanen,et al.  Effects of gender and age on the heritability of body mass index. , 1991, International journal of obesity.

[6]  Y. Hur Sex Difference in Heritability of BMI in South Korean Adolescent Twins , 2007, Obesity.

[7]  H. Snieder,et al.  Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study , 2011, Hypertension Research.

[8]  M. McGue,et al.  Sex and age specific assessment of genetic and environmental influences on body mass index in twins. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[9]  S. Heymsfield,et al.  Race effects in the genetics of adolescents' body mass index. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[10]  Daniel L. Koller,et al.  Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. , 2013, American journal of epidemiology.

[11]  T. Spector,et al.  The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influences. , 2003, Arthritis and rheumatism.

[12]  B. Popkin,et al.  The sweetening of the world's diet. , 2003, Obesity research.

[13]  T. Sørensen,et al.  Increased Genetic Variance of BMI with a Higher Prevalence of Obesity , 2011, PloS one.

[14]  A. Rissanen,et al.  Distribution and heritability of BMI in Finnish adolescents aged 16 y and 17 y: A study of 4884 twins and 2509 singletons , 1999, International Journal of Obesity.

[15]  J. Wardle,et al.  Increasing Heritability of BMI and Stronger Associations With the FTO Gene Over Childhood , 2008, Obesity.

[16]  P. Poulsen,et al.  Genetic versus environmental aetiology of the metabolic syndrome among male and female twins , 2001, Diabetologia.

[17]  H. Snieder,et al.  Heritability of Obesity‐related Phenotypes and Association with Adiponectin Gene Polymorphisms in the Chinese National Twin Registry , 2010, Annals of human genetics.

[18]  L. Groop,et al.  Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins , 2000, Diabetologia.

[19]  Jaakko Kaprio,et al.  Genetics of Tracking of Body Mass Index from Birth to Late Middle Age: Evidence from Twin and Family Studies , 2009, Obesity Facts.

[20]  B. Swinburn,et al.  Economic growth and obesity: an interesting relationship with world-wide implications. , 2012, Economics and human biology.

[21]  M. Lee,et al.  Genetic and environmental relationships between Framingham Risk Score and adiposity measures in Koreans: the Healthy Twin study. , 2012, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[22]  P. Magnus,et al.  Sex‐specific effects for body mass index in the new Norwegian twin panel , 1995, Genetic epidemiology.

[23]  D. Allison,et al.  Genetic and environmental contributions to body mass index: comparative analysis of monozygotic twins, dizygotic twins and same-age unrelated siblings , 2009, International Journal of Obesity.

[24]  Joanne M. Meyer Genetic Studies of Obesity across the Life Span , 1995 .

[25]  L. Lambertini,et al.  Epigenetics in women's health care. , 2010, The Mount Sinai journal of medicine, New York.

[26]  A. Rissanen,et al.  Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins , 2009, International Journal of Obesity.

[27]  Kaare Christensen,et al.  Total and regional fat distribution is strongly influenced by genetic factors in young and elderly twins. , 2005, Obesity research.

[28]  J. Connell,et al.  Glucocorticoids contribute to the heritability of leptin in Scottish adult female twins , 2004, Clinical endocrinology.

[29]  D. Dunger,et al.  Heritability of childhood weight gain from birth and risk markers for adult metabolic disease in prepubertal twins. , 2009, The Journal of clinical endocrinology and metabolism.

[30]  Lina W. Olsen,et al.  Secular Trends in Childhood Obesity in Denmark During 50 Years in Relation to Economic Growth , 2007, Obesity.

[31]  A. Drewnowski,et al.  The nutrition transition: new trends in the global diet. , 2009, Nutrition reviews.

[32]  Xiping Xu,et al.  Adiposity is inversely related to insulin sensitivity in relatively lean Chinese adolescents: a population-based twin study. , 2010, The American journal of clinical nutrition.

[33]  A. Stunkard,et al.  A twin study approach towards understanding genetic contributions to body size and metabolic rate. , 1991, Acta geneticae medicae et gemellologiae.

[34]  K. Alt,et al.  Contribution of genetic and environmental factors to variation in body compartments--a twin study in adults. , 2004, Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur.

[35]  B. Swinburn,et al.  An “ecological” approach to the obesity pandemic , 1997, BMJ.

[36]  G. Willemsen,et al.  Genetic Regulation of Growth in Height and Weight from 3 to 12 Years of Age: A Longitudinal Study of Dutch Twin Children , 2007, Twin Research and Human Genetics.

[37]  G. Beunen,et al.  Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities , 2007, Diabetologia.

[38]  M. McGue,et al.  A cross-sectional examination of height, weight, and body mass index in adult twins. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[39]  D. Allison,et al.  Assortative marriages by body mass index have increased simultaneously with the obesity epidemic , 2012, Front. Gene..

[40]  V. Somers,et al.  Heritability of plasma leptin levels: a twin study. , 1999, Journal of hypertension.

[41]  E. Rampersaud,et al.  Physical activity and the association of common FTO gene variants with body mass index and obesity. , 2008, Archives of internal medicine.

[42]  Ambady Ramachandran,et al.  Trends in prevalence of diabetes in Asian countries. , 2012, World journal of diabetes.

[43]  G. Mcclearn,et al.  The body-mass index of twins who have been reared apart. , 1990, The New England journal of medicine.

[44]  J. Kaprio,et al.  Genetic Influences on Change in BMI from Middle to Old Age: A 29-Year Follow-up Study of Twin Sisters , 2009, Behavior genetics.

[45]  H. Snieder,et al.  Testing the fetal origins hypothesis in twins: the Birmingham twin study , 2001, Diabetologia.

[46]  C. Bogardus Missing Heritability and GWAS Utility , 2009, Obesity.

[47]  B. Popkin,et al.  Why have physical activity levels declined among Chinese adults? Findings from the 1991-2006 China Health and Nutrition Surveys. , 2009, Social science & medicine.

[48]  A. Rissanen,et al.  Body weight in the Finnish Twin Cohort. , 1990, Diabetes research and clinical practice.

[49]  D. Corella,et al.  A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. , 2011, The Journal of nutrition.

[50]  D. Boomsma,et al.  Body Size in Five-Year-Old Twins: Heritability and Comparison to Singleton Standards , 2006, Twin Research and Human Genetics.

[51]  A. Rissanen,et al.  Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins , 2009, International Journal of Obesity.

[52]  F. Rasmussen,et al.  Increasing Genetic Variance of Body Mass Index during the Swedish Obesity Epidemic , 2011, PloS one.

[53]  A. Rissanen,et al.  Modification effects of physical activity and protein intake on heritability of body size and composition. , 2009, The American journal of clinical nutrition.