Coenzymes Q levels in liver, spleen, and blood of mice with Friend leukemia virus infection.

Summary The coenzymes Q levels of blood, spleen, and liver of mice infected with Friend leukemia virus were compared with those of control groups at 10, 20, 30, and 40 days after infection. A significant increase in the total coenzymes Q level in the blood was observed. This increase reaches about fivefold the normal level, 30 days after the infection. The total coenzymes Q concentration in the liver does not change appreciably, but the relative concentration of coenzyme Q10 begins to increase 10 days after infection. No change in coenzymes Q level or in the homolog present was observed in the spleen of the infected mice.

[1]  P. Myers,et al.  Estimation of individual coenzyme Q homologues in a coenzyme Q mixture by densitometry. , 1972, Journal of chromatography.

[2]  B. Chipperfield,et al.  Ubiquinone and nucleic acid concentrations in the heart muscle of cancer patients and normal controls. , 1971, Clinica chimica acta; international journal of clinical chemistry.

[3]  K. Folkers,et al.  Biosynthesis of ubiquinone-10 from p-hydroxybenzoic acid by leucocytes of the human and rhesus monkey. , 1970, Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie.

[4]  W. Phillips,et al.  Ubiquinone levels of human liver in health and disease. , 1969, Canadian Journal of Physiology and Pharmacology.

[5]  P. Efrati,et al.  Cytochemical demonstration of the co-enzyme ubiquinone in normal human blood and bone marrow cells. , 1969, Acta Haematologica.

[6]  K. Folkers,et al.  Determination and levels of coenzyme Q10 in human blood. , 1968, Analytical biochemistry.

[7]  M. Shichiri,et al.  Apparent low levels of ubiquinone in rat and human neoplastic tissues. , 1968, Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie.

[8]  J. Nilsson,et al.  New procedures for assay and stability of coenzyme Q10 in human blood. , 1968, Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie.

[9]  Y. Yamamoto,et al.  Catabolism of cholesterol in a rat transplanted with Walker carcinoma and the interrelation with beta-carotene and ubiquinone. , 1967, Gan.

[10]  T. Sugimura,et al.  Studies on ubiquinone (coenzyme Q) in neoplastic tissues. , 1962, Gan.

[11]  A. Diplock,et al.  The effect of vitamin A on ubiquinone and ubichromenol in the rat, and its relation to the effect of vitamin E , 1962, British Journal of Nutrition.

[12]  I. Brodsky,et al.  A graded-response assay for the Friend leukemia virus. , 1959, Journal of the National Cancer Institute.