ABSENCE OF THE PROLIFERATION OF SMOOTH ENDOPLASMIC RETICULUM IN HEPATOCYTES OF THE MOUSE TREATED WITH DEHYDROACETIC ACID

It is well known that phenobarbital and other chemicals administered to animals cause the marked proliferation of the smooth endoplasmic reticulum in the hepatocyte and stimulate a variety of microsomal drug metabolisms in the liver (l, 2). On the other hand, 3-methylcholanthrene and 3,4-benzpylene have little or no effect on the proliferation of the smooth endoplasmic reticulum, although these chemicals increase the activities of a few drug metabolizing enzymes (1). The