Development, Optimization, and Scale-up of Process Parameters: Pan Coating
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Publisher Summary Film-coating systems are usually defined by the way the coating materials are formulated into a liquid coating system, and typically take the form of polymers applied as organic–solvent-based solutions, polymers applied as aqueous solutions, polymers applied as aqueous dispersions, and various materials applied as hot-melts. Polymers are the main building blocks of coating formulations, providing the main characteristics for the final coating formulation, and are usually characterized in terms of chemistry and molecular weight. Plasticizer is another common ingredient added to coating formulations. They are typically used to reduce the glass transition temperature and increase flexibility. Most polymers used in film-coating are essentially amorphous materials and, as such, exhibit a reasonably well-defined glass transition temperature. Colorants are typically used in film-coating formulations to improve product appearance, aid in product identification, and improve product stability. Polymers used in immediate-release film-coating formulations are generally water-soluble. Polymers are selected for their ability to form strong, flexible films, adhere strongly to tablet surfaces, form elegant films, facilitate ease of processing, and permit rapid drug release from dosage forms. Some of the polymers used in immediate-release coating formulations are cellulosic polymers, vinyl alcohol polymers, and acrylic polymers.