Inhibition of thymidylate synthase activity by antisense oligodeoxynucleotide and possible role in thymineless treatment.
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H. Tsai | K. Choo | L. Au | S. B. Lin | Y. Lim | P. Ts'o | S. K. Sun | F. Yang | S. K. Sun | S. B. Lin
[1] C. Chi,et al. In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-α , 2000 .
[2] D. Fabbro,et al. bcl‐xl antisense treatment induces apoptosis in breast carcinoma cells , 2000, International journal of cancer.
[3] N. Suzuki,et al. Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells. , 2000, International journal of oncology.
[4] A D Tsodikov,et al. Identification of sequence motifs in oligonucleotides whose presence is correlated with antisense activity. , 2000, Nucleic acids research.
[5] A. Rishi,et al. S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid. , 2000, Cancer research.
[6] N. Dean,et al. Antisense down‐regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5‐FUdR, 5‐FU and Tomudex in HeLa cells , 1999, British journal of pharmacology.
[7] J. C. Schmitz,et al. Repression of human thymidylate synthase mRNA translation by antisense 2'-O-methyl oligoribonucleotides. , 1998, Antisense & nucleic acid drug development.
[8] J. Koropatnick,et al. Antisense nucleic acids targeted to the thymidylate synthase (TS) mRNA translation start site stimulate TS gene transcription. , 1998, Experimental cell research.
[9] Shwu-Bin Lin,et al. Protein Kinase C η Mediates Lipopolysaccharide-induced Nitric-oxide Synthase Expression in Primary Astrocytes* , 1998, The Journal of Biological Chemistry.
[10] R. Haas,et al. Antisense strategies for the treatment of hematological malignancies and solid tumors , 1998, Annals of Hematology.
[11] A. Boulares,et al. Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis* , 1998, The Journal of Biological Chemistry.
[12] D. Stacey,et al. Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide , 1997, Oncogene.
[13] M. Lai,et al. Antisense oligodeoxynucleotides of IGF-II selectively inhibit growth of human hepatoma cells overproducing IGF-II. , 1997, Journal of biochemistry.
[14] R. Gelber,et al. Prognostic importance of thymidylate synthase expression in early breast cancer. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[15] H E Rockette,et al. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] R. Wagner. Gene inhibition using antisense oligodeoxynucleotides , 1994, Nature.
[17] T. Tamada,et al. Thymidylate synthase activity as a prognostic factor in ovarian cancer. , 1994, Oncology.
[18] L. Johnson. Posttranscriptional regulation of thymidylate synthase gene expression , 1994, Journal of cellular biochemistry.
[19] K. Keyomarsi,et al. The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme. , 1993, The Journal of biological chemistry.
[20] R. Tallarida,et al. Mechanisms of excision of 5-fluorouracil by uracil DNA glycosylase in normal human cells. , 1993, Molecular pharmacology.
[21] M. Yin,et al. Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine. , 1993, Biochemical pharmacology.
[22] G. Maley,et al. Identification of an RNA binding site for human thymidylate synthase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[23] I. Judson,et al. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. , 1991, Cancer research.
[24] M. Yin,et al. Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition. , 1991, Cancer communications.
[25] R. Eritja,et al. Equilibrium between a wobble and ionized base pair formed between fluorouracil and guanine in DNA as studied by proton and fluorine NMR. , 1988, The Journal of biological chemistry.
[26] R M Stroud,et al. Atomic structure of thymidylate synthase: target for rational drug design. , 1987, Science.
[27] O. Gotoh,et al. Nucleic Acids Research Nucleotide sequence of a functional cDNA for human thymldylate synthase , 2004 .
[28] C. Heidelberger,et al. Fluorinated pyrimidines and their nucleosides. , 1983, Advances in enzymology and related areas of molecular biology.
[29] L. Johnson,et al. Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts , 1982, Molecular and cellular biology.
[30] Masao Tanaka,et al. Utilization of 5-Fluoro-2′-deoxyuridine Triphosphate and 5-Fluoro-2′-deoxycytidine Triphosphate in DNA Synthesis by DNA Polymerases α and β from Calf Thymus , 1981 .
[31] S. Yoshida,et al. Utilization of 5-fluoro-2'-deoxyuridine triphosphate and 5-fluoro-2'-deoxycytidine triphosphate in DNA synthesis by DNA polymerases alpha and beta from calf thymus. , 1981, Cancer research.
[32] H. Ingraham,et al. Mechanism for exclusion of 5-fluorouracil from DNA. , 1980, Cancer research.
[33] P. Danenberg. Thymidylate synthetase - a target enzyme in cancer chemotherapy. , 1977, Biochimica et biophysica acta.
[34] D. Santi,et al. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. , 1974, Biochemistry.