Fluid-structure interaction analysis of a patient-specific right coronary artery with physiological velocity and pressure waveforms

Coupled fluid–structure interaction (FSI) analysis of the human right coronary artery (RCA) has been carried out to investigate the effects of wall compliance on coronary hemodynamics. A 3-D model of a stenosed RCA was reconstructed based on multislice computerized tomography images. A velocity waveform in the proximal RCA and a pressure waveform in the distal RCA of a patient with a severe stenosis were acquired with a catheter delivered wire probe and applied as boundary conditions. The arterial wall was modeled as a Mooney–Rivlin hyperelastic material. The predicted maximum wall displacement (3.85 mm) was comparable with the vessel diameter (∼4 mm), but the diameter variation was much smaller, 0.134 mm at the stenosis and 0.486 mm in the distal region. Comparison of the computational results between the FSI and rigid-wall models showed that the instantaneous wall shear stress (WSS) distributions were affected by diameter variation in the arterial wall; increasing systolic blood pressure dilated the vessel and consequently lowered WSS, whereas the opposite occurred when pressure started to decrease. However, the effects of wall compliance on time-averaged WSS (TAWSS) and oscillatory shear index (OSI) were insignificant (4.5 and 2.7% difference in maximum TAWSS and OSI, respectively). Copyright © 2009 John Wiley & Sons, Ltd.

[1]  A. Hughes,et al.  Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery. , 2008, American journal of physiology. Heart and circulatory physiology.

[2]  Dimos Poulikakos,et al.  A study on the compliance of a right coronary artery and its impact on wall shear stress. , 2008, Journal of biomechanical engineering.

[3]  T. Tezduyar,et al.  Arterial fluid mechanics modeling with the stabilized space–time fluid–structure interaction technique , 2008 .

[4]  C. M. Scotti,et al.  Wall stress and flow dynamics in abdominal aortic aneurysms: finite element analysis vs. fluid–structure interaction , 2008, Computer methods in biomechanics and biomedical engineering.

[5]  N. Koshiba,et al.  Multiphysics simulation of blood flow and LDL transport in a porohyperelastic arterial wall model. , 2007, Journal of biomechanical engineering.

[6]  Milan Sonka,et al.  Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study. , 2007, European heart journal.

[7]  Thomas H Marwick,et al.  A new technique for assessing arterial pressure wave forms and central pressure with tissue Doppler , 2007, Cardiovascular ultrasound.

[8]  Guang-Zhong Yang,et al.  Evaluation of carotid artery wall volume measurement using novel semiautomated analysis software , 2006, Journal of magnetic resonance imaging : JMRI.

[9]  Alejandro F. Frangi,et al.  CFD Analysis Incorporating the Influence of Wall Motion: Application to Intracranial Aneurysms , 2006, MICCAI.

[10]  Charles A. Taylor,et al.  A coupled momentum method for modeling blood flow in three-dimensional deformable arteries , 2006 .

[11]  T. Tezduyar,et al.  Fluid–structure Interaction Modeling of Aneurysmal Conditions with High and Normal Blood Pressures , 2006 .

[12]  Alun D. Hughes,et al.  Evidence of a Dominant Backward-Propagating “Suction” Wave Responsible for Diastolic Coronary Filling in Humans, Attenuated in Left Ventricular Hypertrophy , 2006, Circulation.

[13]  J. M. Tarbell,et al.  A Computational Study of Flow in a Compliant Carotid Bifurcation–Stress Phase Angle Correlation with Shear Stress , 2005, Annals of Biomedical Engineering.

[14]  P. Serruys,et al.  The role of shear stress in the destabilization of vulnerable plaques and related therapeutic implications , 2005, Nature Clinical Practice Cardiovascular Medicine.

[15]  Frits Mastik,et al.  Three-Dimensional Palpography of Human Coronary Arteries , 2005, Herz Kardiovaskuläre Erkrankungen.

[16]  Dalin Tang,et al.  3D MRI-Based Multicomponent FSI Models for Atherosclerotic Plaques , 2004, Annals of Biomedical Engineering.

[17]  Hui Zhu,et al.  Relationship Between the Dynamic Geometry and Wall Thickness of a Human Coronary Artery , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[18]  Jie Zheng,et al.  Effect of Stenosis Asymmetry on Blood Flow and Artery Compression: A Three-Dimensional Fluid-Structure Interaction Model , 2003, Annals of Biomedical Engineering.

[19]  Fotis Sotiropoulos,et al.  Numerical simulation of flow in mechanical heart valves: grid resolution and the assumption of flow symmetry. , 2003, Journal of biomechanical engineering.

[20]  C. Ross Ethier,et al.  Effects of Cardiac Motion on Right Coronary Artery Hemodynamics , 2003, Annals of Biomedical Engineering.

[21]  A. Hughes,et al.  Reproducibility Study of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Carotid Bifurcation Flow , 2003, Annals of Biomedical Engineering.

[22]  R D Kamm,et al.  On the sensitivity of wall stresses in diseased arteries to variable material properties. , 2003, Journal of biomechanical engineering.

[23]  Morton H. Friedman,et al.  Coronary Artery Dynamics In Vivo , 2002, Annals of Biomedical Engineering.

[24]  C. R. Ethier,et al.  Factors Influencing Blood Flow Patterns in the Human Right Coronary Artery , 2001, Annals of Biomedical Engineering.

[25]  R. Ogden,et al.  A New Constitutive Framework for Arterial Wall Mechanics and a Comparative Study of Material Models , 2000 .

[26]  M. Unser,et al.  Interpolation revisited [medical images application] , 2000, IEEE Transactions on Medical Imaging.

[27]  S. Alper,et al.  Hemodynamic shear stress and its role in atherosclerosis. , 1999, JAMA.

[28]  L. Brush,et al.  McDonaldʼs Blood Flow in Arteries , 1991 .

[29]  T. O'donnell,et al.  Pulsatile flow and atherosclerosis in the human carotid bifurcation: Positive correlation between plaque location and low and oscillating shear stress: Ku DN, Giddens DP, Zarins CK, et al. Arteriosclerosis 1985; 5: 293–302 , 1986 .

[30]  C. Rhie,et al.  A numerical study of the turbulent flow past an isolated airfoil with trailing edge separation , 1982 .

[31]  R. Schroter,et al.  Arterial Wall Shear and Distribution of Early Atheroma in Man , 1969, Nature.

[32]  J. Womersley.  Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known , 1955, The Journal of physiology.

[33]  S. Einav,et al.  Influence of microcalcifications on vulnerable plaque mechanics using FSI modeling. , 2008, Journal of biomechanics.

[34]  Erling Falk,et al.  Mechanical stresses in carotid plaques using MRI-based fluid-structure interaction models. , 2008, Journal of biomechanics.

[35]  D. Vorp,et al.  Biomechanics of abdominal aortic aneurysm. , 2007, Journal of biomechanics.

[36]  P. Hoskins,et al.  Numerical analysis of pulsatile blood flow and vessel wall mechanics in different degrees of stenoses. , 2007, Journal of biomechanics.

[37]  D. Vorp,et al.  The effects of aneurysm on the biaxial mechanical behavior of human abdominal aorta. , 2006, Journal of biomechanics.

[38]  R. Ogden,et al.  Mechanics of biological tissue , 2006 .

[39]  G. Truskey,et al.  Hemodynamic parameters and early intimal thickening in branching blood vessels. , 2001, Critical reviews in biomedical engineering.

[40]  M. Unser,et al.  Interpolation Revisited , 2000, IEEE Trans. Medical Imaging.

[41]  D. Liepsch,et al.  Flow Characteristics in an Anatomically Realistic Compliant Carotid Artery Bifurcation Model. , 1999, Computer methods in biomechanics and biomedical engineering.

[42]  Timothy J. Barth,et al.  The design and application of upwind schemes on unstructured meshes , 1989 .