Placenta to cartilage: direct conversion of human placenta to chondrocytes with transformation by defined factors

A combination of only five genes—BCL6, T, c-MYC, MITF, and BAF60C—rapidly and efficiently converts postnatal human amnion into chondrocytes. This direct conversion system from noncartilage tissue to cartilaginous tissue is a major advance toward understanding cartilage development, cell-based therapy, and oncogenesis of chondrocytes.

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