Chapter 14 – Continuous Operations

[1]  Tom Van Gerven,et al.  A review of intensification of photocatalytic processes , 2007 .

[2]  Robert C. R. Wootton,et al.  A Microfabricated Nanoreactor for Safe, Continuous Generation and Use of Singlet Oxygen , 2002 .

[3]  Martyn Poliakoff,et al.  The Continuous Acid-Catalysed Etherification of Aliphatic Alcohols Using Stoichiometric Quantities of Dialkyl Carbonates , 2010 .

[4]  Wolfgang Ehrfeld,et al.  Microreactors: New Technology for Modern Chemistry , 2000 .

[5]  Lukas Küpper,et al.  An Ozonolysis−Reduction Sequence for the Synthesis of Pharmaceutical Intermediates in Microstructured Devices , 2009 .

[6]  San Kiang,et al.  Crystallization Process Development of an Active Pharmaceutical Ingredient and Particle Engineering via the Use of Ultrasonics and Temperature Cycling , 2003 .

[7]  Paul Watts,et al.  The synthesis of peptides using micro reactors , 2001 .

[8]  Jeffrey M. Kallemeyn,et al.  The Development of Continuous Process for Alkene Ozonolysis Based on Combined in Situ FTIR, Calorimetry, and Computational Chemistry , 2011 .

[9]  M. Fray,et al.  [3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions , 2010 .

[10]  Paul Watts,et al.  Benchmarking of Microreactor Applications , 2004 .

[11]  Nicholas E. Leadbeater,et al.  Preparation of cisplatin using microwave heating and continuous-flow processing as tools , 2011 .

[12]  Gregory Hughes,et al.  Development of an Improved Immobilized CAL-B for the Enzymatic Resolution of a Key Intermediate to Odanacatib , 2011 .

[13]  Patricia Short.  MICROREACTORS HIT THE MAJOR LEAGUES: Suppliers of microreactor technology aim BEYOND SPECIALTY NICHES at industrial markets , 2008 .

[14]  Etzer Darout,et al.  The synthesis of azabicyclic heterocycles , 2010 .

[15]  Ricardo J. Bogaert-Alvarez,et al.  Continuous Processing to Control a Potentially Hazardous Process: Conversion of Aryl 1,1-Dimethylpropargyl Ethers to 2,2-Dimethylchromenes (2,2-Dimethyl-2H-1-Benzopyrans) , 2001 .

[16]  V. Rekha,et al.  A Simple, Efficient, Green, Cost Effective and Chemoselective Process for the Esterification of Carboxylic Acids , 2009 .

[17]  Zuyi Li,et al.  A practical high through-put continuous process for the synthesis of chiral cyanohydrins. , 2002, The Journal of organic chemistry.

[18]  Michael Freemantle.  NEWS OF THE WEEK: FINDING THE BEST CONDITIONS RAPIDLYMicrofluidic device can optimize even complex organic transformations , 2005 .

[19]  Jeffrey A. Pfefferkorn,et al.  Development of an Early Enabling Synthesis for PF-03052334-02: A Novel Hepatoselective HMG-CoA Reductase Inhibitor , 2011 .

[20]  Klavs F Jensen,et al.  Microreactor-based reaction optimization in organic chemistry--glycosylation as a challenge. , 2005, Chemical communications.

[21]  Rick Mullin.  PAYING ATTENTION TO MANUFACTURING: Consortia aim to BRIDGE THE GAP between drug development and manufacturing with a technology and engineering focus , 2011 .

[22]  Paul Watts,et al.  Micro reactors: a new tool for the synthetic chemist. , 2007, Organic & biomolecular chemistry.

[23]  Steven V. Ley,et al.  The Changing Face of Organic Synthesis , 2008 .

[24]  Martin D. Johnson,et al.  Development of Safe and Scalable Continuous-Flow Methods for Palladium-Catalyzed Aerobic Oxidation Reactions. , 2010, Green chemistry : an international journal and green chemistry resource : GC.

[25]  Russell Dahl,et al.  Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence. , 2008, The Journal of organic chemistry.

[26]  Mark Pickworth,et al.  A practical flow reactor for continuous organic photochemistry. , 2005, The Journal of organic chemistry.

[27]  Simon J. F. Macdonald,et al.  A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor , 2011 .

[28]  S. Haswell,et al.  Clean and selective oxidation of aromatic alcohols using silica-supported Jones’ reagent in a pressure-driven flow reactor , 2006 .

[29]  Michael A. Gonzalez,et al.  High Conversion, Solvent Free, Continuous Synthesis of Imidazolium Ionic Liquids In Spinning Tube-in-Tube Reactors , 2009 .

[30]  J. W. Butcher,et al.  Synthesis of semisynthetic dipeptides using N-carboxyanhydrides and chiral induction on raney nickel. A method practical for large scale , 1988 .

[31]  Mark W. Becker,et al.  Research and Development of an Efficient Synthesis of Hexahydrofuro[2,3-b]furan-3-ol Moiety—A Key Component of the HIV Protease Inhibitor Candidates , 2007 .

[32]  A Manz,et al.  Chemical amplification: continuous-flow PCR on a chip. , 1998, Science.

[33]  Keith J. Carpenter,et al.  Process Development: Physicochemical Concepts , 2000 .

[34]  Edward L. Paul,et al.  Crystallization of Organic Compounds: An Industrial Perspective , 2009 .

[35]  Jeremy L. Steinbacher,et al.  Greener approaches to organic synthesis using microreactor technology. , 2007, Chemical reviews.

[36]  Gary A. Leeke,et al.  Continuous-Flow Suzuki−Miyaura Reaction in Supercritical Carbon Dioxide , 2007 .

[37]  Oljan Repic,et al.  Large scale microwave-accelerated esterification of carboxylic acids with dimethyl carbonate , 2002 .

[38]  Steven V. Ley,et al.  Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles , 2007 .

[39]  Floris P. J. T. Rutjes,et al.  Fast Scale-Up Using Microreactors: Pyrrole Synthesis from Micro to Production Scale , 2011 .

[40]  Steven J. Broadwater,et al.  The continuous-flow synthesis of Ibuprofen. , 2009, Angewandte Chemie.

[41]  A. Maureen Rouhi.  MICROREACTORS EYED FOR INDUSTRIAL USE , 2004 .

[42]  N. Hoffmann,et al.  Photochemical reactions as key steps in organic synthesis. , 2008, Chemical reviews.

[43]  Uwe Dingerdissen,et al.  Ozonolysis of Acetic Acid 1-Vinyl-hexyl Ester in a Falling Film Microreactor , 2007 .

[44]  J. Hutton,et al.  A SIMPLE LABORATORY PROCEDURE FOR THE PREPARATION OF NITRILES FROM ALCOHOLS VIA UNSTABLE CHLORIDES IN LARGE QUANTITIES , 1980 .

[45]  Michael Freemantle.  MICROPROCESSING ON A LARGE SCALE: Use of microchannel reactors for the chemical process industries gathers momentum , 2004 .

[46]  L. Proctor,et al.  Development of a Continuous Process for the Industrial Generation of Diazomethane1 , 2002 .

[47]  T. Mason.  Ultrasound in synthetic organic chemistry , 1997 .

[48]  C. Oliver Kappe,et al.  Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes , 2010 .

[49]  P. Hampton,et al.  Continuous Organic Synthesis in a Spinning Tube-in-Tube Reactor: TEMPO-Catalyzed Oxidation of Alcohols by Hypochlorite , 2008 .

[50]  Dominique M. Roberge,et al.  Dibal-H Reduction of Methyl Butyrate into Butyraldehyde using Microreactors , 2008 .

[51]  Timothy M. Braden,et al.  Improved Synthesis of 1-(Azidomethyl)-3,5-bis-(trifluoromethyl)benzene: Development of Batch and Microflow Azide Processes , 2009 .

[52]  Dominique M. Roberge,et al.  Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries? , 2005 .

[53]  Nicholas E. Leadbeater,et al.  An approach for continuous-flow processing of reactions that involve the in situ formation of organic products , 2011 .

[54]  Ulf Tilstam,et al.  The Newman−Kwart Rearrangement Revisited: Continuous Process under Supercritical Conditions† , 2009 .

[55]  Martyn Poliakoff,et al.  Continuous Acid-Catalyzed Methylations in Supercritical Carbon Dioxide: Comparison of Methanol, Dimethyl Ether and Dimethyl Carbonate as Methylating Agents , 2010 .

[56]  M. Fabiilli,et al.  On-Line Analysis of a Continuous-Flow Ozonolysis Reaction Using Raman Spectroscopy , 2007, Applied spectroscopy.

[57]  Zhihong Chen,et al.  A Practical Method for N-Methylation of Indoles Using Dimethyl Carbonate , 2001 .

[58]  Oljan Repic,et al.  Dual nucleophilic catalysis with DABCO for the N-methylation of indoles. , 2003, The Journal of organic chemistry.

[59]  Timothy Noël,et al.  Suzuki-Miyaura cross-coupling reactions in flow: multistep synthesis enabled by a microfluidic extraction. , 2011, Angewandte Chemie.

[60]  Peng Wang,et al.  Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction , 2008 .

[61]  Klavs F. Jensen,et al.  Overcoming the Challenges of Solid Bridging and Constriction during Pd-Catalyzed C−N Bond Formation in Microreactors , 2010 .

[62]  Daniele Vigo,et al.  Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation. , 2009, The Journal of organic chemistry.

[63]  K. Mae,et al.  Room-temperature Swern oxidations by using a microscale flow system. , 2005, Angewandte Chemie.

[64]  N. Anderson.  Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes , 2001 .

[65]  George W. Roberts,et al.  Chemical reactions and chemical reactors , 2008 .

[66]  Asterios Gavriilidis,et al.  Ozonolysis in Flow Using Capillary Reactors , 2011 .

[67]  Michael W. George,et al.  Could the energy cost of using supercritical fluids be mitigated by using CO2 from carbon capture and storage (CCS) , 2011 .

[68]  Klavs F. Jensen,et al.  Aminolysis of Epoxides in a Microreactor System: A Continuous Flow Approach to β-Amino Alcohols , 2010 .

[69]  Edward L. Paul.  Design of reaction systems for specialty organic chemicals , 1988 .

[70]  Nicholas E. Leadbeater,et al.  Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor , 2010 .

[71]  Colin Ramshaw,et al.  Evaluation of a Spinning Disc Reactor for Continuous Processing1 , 2001 .

[72]  Nicholas E. Leadbeater,et al.  Approaches for Scale-Up of Microwave-Promoted Reactions , 2008 .

[73]  B. A. Pearlman,et al.  Synthesis of N-methyl-N-[(1S)-1-[(3R)-pyrrolidin-3-yl]ethyl]amine. , 2003, The Journal of organic chemistry.

[74]  Neal G. Anderson,et al.  Current Practices of Process Validation for Drug Substances and Intermediates , 2011 .

[75]  N. Kockmann,et al.  Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway? , 2008 .

[76]  Julie Zimmerman,et al.  Design Through the 12 Principles of Green Engineering , 2003, IEEE Engineering Management Review.