Flavonoids Isolated from Heat-Processed Epimedium koreanum and Their Anti-HIV-1 Activities

Systematic phytochemical investigation on heat-processed Epimedium koreanum led to the isolation of 13 flavonoids, including five new prenyl-flavonol glycosides, koreanosides A–E (1–5, resp.). Their structures were elucidated on the basis of detailed analysis of the 1D- and 2D-NMR spectroscopic data and chemical reactions. Apigenin (11) exhibited moderate anti-HIV-1 activity with an EC50 value of 12.8±3.27 μg/ml.

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