Degradation of synthetic polymeric scaffolds for bone and cartilage tissue repairs

Degradation studies are reported with emphasis on polymeric scaffolds in which degradation occurs viaester bond cleavage. The temporal and structural consequences of polymer degradation on TE scaffolds in the absence and in the presence of biological components in vitro and in vivo are described and compared. Finally, the functional improvement of degradable polymeric scaffolds for TEvia the formation of hybrid structures is presented.

[1]  Jingzhe Pan,et al.  A phenomenological model for the degradation of biodegradable polymers. , 2008, Biomaterials.

[2]  S. Gogolewski,et al.  Structure-property relations and cytotoxicity of isosorbide-based biodegradable polyurethane scaffolds for tissue repair and regeneration. , 2008, Journal of biomedical materials research. Part A.

[3]  S. Guelcher,et al.  Biodegradable polyurethanes: synthesis and applications in regenerative medicine. , 2008, Tissue engineering. Part B, Reviews.

[4]  H. Mizumoto,et al.  Development of articular cartilage grafts using organoid formation techniques. , 2008, Transplantation proceedings.

[5]  M. Alini,et al.  Effect of reduced oxygen tension and long-term mechanical stimulation on chondrocyte-polymer constructs , 2008, Cell and Tissue Research.

[6]  S. Lopina,et al.  Oxidative and enzymatic degradations of l-tyrosine based polyurethanes , 2007 .

[7]  Jun Li,et al.  Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol). , 2007, Biomaterials.

[8]  Hinrich Wiese,et al.  In vitro and in vivo cartilage engineering using a combination of chondrocyte-seeded long-term stable fibrin gels and polycaprolactone-based polyurethane scaffolds. , 2007, Tissue engineering.

[9]  S. Guelcher,et al.  Synthesis, in vitro degradation, and mechanical properties of two-component poly(ester urethane)urea scaffolds: effects of water and polyol composition. , 2007, Tissue engineering.

[10]  Matthias P Lutolf,et al.  Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering. , 2007, Biomaterials.

[11]  Paolo A. Netti,et al.  The performance of poly-ε-caprolactone scaffolds in a rabbit femur model with and without autologous stromal cells and BMP4 , 2007 .

[12]  A. Albertsson,et al.  Degradation Profile of Poly(ϵ‐caprolactone)–the Influence of Macroscopic and Macromolecular Biomaterial Design , 2007 .

[13]  Gordana Vunjak-Novakovic,et al.  Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. , 2007, Biomaterials.

[14]  K. Woodhouse,et al.  Characterization of biodegradable polyurethane microfibers for tissue engineering , 2007, Journal of biomaterials science. Polymer edition.

[15]  Masayuki Yamato,et al.  Cell delivery in regenerative medicine: the cell sheet engineering approach. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[16]  M. Wimmer,et al.  Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds. , 2006, Tissue engineering.

[17]  Ralph Müller,et al.  Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part II: biofunctional characteristics. , 2006, Biomacromolecules.

[18]  Shuguang Zhang,et al.  Slow release of molecules in self-assembling peptide nanofiber scaffold. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[19]  Rein V. Ulijn,et al.  Peptide-based stimuli-responsive biomaterials. , 2006, Soft matter.

[20]  Zhiyuan Zhong,et al.  In-situ formation of biodegradable hydrogels by stereocomplexation of PEG-(PLLA)8 and PEG-(PDLA)8 star block copolymers. , 2006, Biomacromolecules.

[21]  Kwideok Park,et al.  Scaffold-free, engineered porcine cartilage construct for cartilage defect repair--in vitro and in vivo study. , 2006, Artificial organs.

[22]  Kristi S Anseth,et al.  Manipulations in hydrogel degradation behavior enhance osteoblast function and mineralized tissue formation. , 2006, Tissue engineering.

[23]  Sylwester Gogolewski,et al.  Regeneration of bicortical defects in the iliac crest of estrogen-deficient sheep, using new biodegradable polyurethane bone graft substitutes. , 2006, Journal of biomedical materials research. Part A.

[24]  Joseph Jagur-Grodzinski,et al.  Polymers for tissue engineering, medical devices, and regenerative medicine. Concise general review of recent studies , 2006 .

[25]  Ivan Martin,et al.  Cartilage tissue engineering for degenerative joint disease. , 2006, Advanced drug delivery reviews.

[26]  Jerry C. Hu,et al.  A self-assembling process in articular cartilage tissue engineering. , 2006, Tissue engineering.

[27]  W. Tsai,et al.  The effects of types of degradable polymers on porcine chondrocyte adhesion, proliferation and gene expression , 2006, Journal of materials science. Materials in medicine.

[28]  Kristi S Anseth,et al.  The effect of ethylene glycol methacrylate phosphate in PEG hydrogels on mineralization and viability of encapsulated hMSCs. , 2006, Biomaterials.

[29]  H. Bianco-Peled,et al.  The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration. , 2006, Biomaterials.

[30]  Linbo Wu,et al.  Effects of porosity and pore size on in vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering. , 2005, Journal of biomedical materials research. Part A.

[31]  K. Woodhouse,et al.  Understanding the biodegradation of polyurethanes: from classical implants to tissue engineering materials. , 2005, Biomaterials.

[32]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[33]  W. D. de Jong,et al.  Tissue response to partially in vitro predegraded poly-L-lactide implants. , 2005, Biomaterials.

[34]  Lawrence J Bonassar,et al.  Poly(lactide-co-glycolide) microspheres as a moldable scaffold for cartilage tissue engineering. , 2005, Biomaterials.

[35]  Todd Emrick,et al.  PEG- and peptide-grafted aliphatic polyesters by click chemistry. , 2005, Journal of the American Chemical Society.

[36]  Michel Vert,et al.  Aliphatic polyesters: great degradable polymers that cannot do everything. , 2005, Biomacromolecules.

[37]  B. Ratner,et al.  Synthesis of segmented poly(ether urethane)s and poly(ether urethane urea)s incorporating various side-chain or backbone functionalities , 2005, Journal of biomaterials science. Polymer edition.

[38]  S. Golledge,et al.  Poly(ether urethane)s incorporating long alkyl side-chains with terminal carboxyl groups as fatty acid mimics: synthesis, structural characterization and protein adsorption , 2005, Journal of biomaterials science. Polymer edition.

[39]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[40]  Linbo Wu,et al.  In vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering. , 2004, Biomaterials.

[41]  Chad Johnson,et al.  The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. , 2004, Biomaterials.

[42]  Dietmar W Hutmacher,et al.  Current strategies for cell delivery in cartilage and bone regeneration. , 2004, Current opinion in biotechnology.

[43]  Matthias P Lutolf,et al.  Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair. , 2004, Tissue engineering.

[44]  Christine E Schmidt,et al.  Development of photocrosslinkable hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineering. , 2004, Journal of biomedical materials research. Part A.

[45]  C. Perry,et al.  Comparative study of the in vitro apatite-forming ability of poly(epsilon-caprolactone)-silica sol-gels using three osteoconductivity tests (static, dynamic, and alternate soaking process). , 2004, Journal of biomedical materials research. Part A.

[46]  R. Jayakumar,et al.  Preparation and characterization of injectable microspheres of contraceptive hormones. , 2003, International journal of pharmaceutics.

[47]  Mauro Alini,et al.  The use of biodegradable polyurethane scaffolds for cartilage tissue engineering: potential and limitations. , 2003, Biomaterials.

[48]  Sylwester Gogolewski,et al.  Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes. , 2003, Journal of biomedical materials research. Part A.

[49]  D J Mooney,et al.  Regulating Bone Formation via Controlled Scaffold Degradation , 2003, Journal of dental research.

[50]  P. Martens,et al.  Tailoring the degradation of hydrogels formed from multivinyl poly(ethylene glycol) and poly(vinyl alcohol) macromers for cartilage tissue engineering. , 2003, Biomacromolecules.

[51]  A. Göpferich,et al.  Why degradable polymers undergo surface erosion or bulk erosion. , 2002, Biomaterials.

[52]  Antonios G Mikos,et al.  Evaluation of the in vitro degradation of macroporous hydrogels using gravimetry, confined compression testing, and microcomputed tomography. , 2002, Biomacromolecules.

[53]  J. Fisher,et al.  Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model. , 2002, Journal of biomedical materials research.

[54]  J. Hubbell,et al.  Poly(ethylene glycol) block copolymers. , 2002, Journal of biotechnology.

[55]  Allan S Hoffman,et al.  Hydrogels for biomedical applications. , 2002, Advanced drug delivery reviews.

[56]  B L Currier,et al.  Biodegradable Polymer Scaffolds for Cartilage Tissue Engineering , 2001, Clinical orthopaedics and related research.

[57]  Larry L. Hench,et al.  Biomedical materials for new millennium: perspective on the future , 2001 .

[58]  O. Böstman,et al.  Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review. , 2000, Biomaterials.

[59]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[60]  S. Gogolewski,et al.  Bioresorbable polymers in trauma and bone surgery. , 2000, Injury.

[61]  P. Neuenschwander,et al.  DegraPol-foam: a degradable and highly porous polyesterurethane foam as a new substrate for bone formation. , 2000, Artificial organs.

[62]  J C Middleton,et al.  Synthetic biodegradable polymers as orthopedic devices. , 2000, Biomaterials.

[63]  K. Br,et al.  Current status of DNA vaccines in veterinary medicine. , 2000 .

[64]  R Langer,et al.  In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams. , 2000, Biomaterials.

[65]  J O Hollinger,et al.  Options for tissue engineering to address challenges of the aging skeleton. , 2000, Tissue engineering.

[66]  J. Vacanti,et al.  In vitro degradation of porous poly(L-lactic acid) foams. , 2000, Biomaterials.

[67]  O. Böstman,et al.  Adverse Tissue Reactions to Bioabsorbable Fixation Devices , 2000, Clinical orthopaedics and related research.

[68]  P. Moghe,et al.  Analysis of 3-D microstructure of porous poly(lactide-glycolide) matrices using confocal microscopy. , 1998, Journal of biomedical materials research.

[69]  Kyriacos A. Athanasiou,et al.  The effects of porosity on in vitro degradation of polylactic acid- polyglycolic acid implants used in repair of articular cartilage , 1998 .

[70]  S. Gogolewski,et al.  Effect of in vivo and in vitro degradation on molecular and mechanical properties of various low-molecular-weight polylactides. , 1997, Journal of biomedical materials research.

[71]  P. Neuenschwander,et al.  Development of degradable polyesterurethanes for medical applications: in vitro and in vivo evaluations. , 1997, Journal of biomedical materials research.

[72]  S. Gogolewski,et al.  Long-term in vivo degradation and bone reaction to various polylactides. 1. One-year results. , 1997, Biomaterials.

[73]  G Ciardelli,et al.  Interactions of osteoblasts and macrophages with biodegradable and highly porous polyesterurethane foam and its degradation products. , 1996, Journal of biomedical materials research.

[74]  Suming Li,et al.  Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence. , 1995, Biomaterials.

[75]  K. Mauritz,et al.  Bioabsorbable composites. II: Nontoxic, L-lysine-based poly(ester-urethane) matrix composites , 1993 .

[76]  S. M. Li,et al.  Bioresorbability and biocompatibility of aliphatic polyesters , 1992 .

[77]  J. Heller Controlled drug release from poly(ortho esters) — A surface eroding polymer☆ , 1985 .

[78]  R. Holmes,et al.  Bone Regeneration Within a Coralline Hydroxyapatite Implant , 1979, Plastic and reconstructive surgery.

[79]  S F Hulbert,et al.  Potential of ceramic materials as permanently implantable skeletal prostheses. , 1970, Journal of biomedical materials research.

[80]  S. Bryant,et al.  The role of hydrogel structure and dynamic loading on chondrocyte gene expression and matrix formation. , 2008, Journal of biomechanics.

[81]  Ivan Martin,et al.  Osteochondral tissue engineering. , 2007, Journal of biomechanics.

[82]  K. Anseth,et al.  The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation. , 2007, Biomaterials.

[83]  Achim Goepferich,et al.  Rational design of hydrogels for tissue engineering: impact of physical factors on cell behavior. , 2007, Biomaterials.

[84]  S. Gogolewski,et al.  Biodegradable polyurethane cancellous bone graft substitutes in the treatment of iliac crest defects. , 2007, Journal of biomedical materials research. Part A.

[85]  Christine E Schmidt,et al.  Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds. , 2005, Biomaterials.

[86]  Stephanie J Bryant,et al.  Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. , 2003, Journal of biomedical materials research. Part A.

[87]  S. Gogolewski,et al.  In vitro degradation of novel medical biodegradable aliphatic polyurethanes based on ϵ-caprolactone and Pluronics® with various hydrophilicities , 2002 .

[88]  S. Bryant,et al.  Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels. , 2002, Journal of biomedical materials research.

[89]  P Augat,et al.  In vivo investigations on composites made of resorbable ceramics and poly(lactide) used as bone graft substitutes. , 2001, Journal of biomedical materials research.

[90]  Y. Ikada,et al.  In vitro and in vivo comparison of bulk and surface hydrolysis in absorbable polymer scaffolds for tissue engineering. , 1999, Journal of biomedical materials research.

[91]  P. Neuenschwander,et al.  Chondrocyte-biocompatibility of DegraPol-foam: in vitro evaluations. , 1999, Journal of biomaterials science. Polymer edition.

[92]  C. M. Agrawal,et al.  The effects of dynamic compressive loading on biodegradable implants of 50-50% polylactic Acid-polyglycolic Acid. , 1996, Tissue engineering.

[93]  A. Göpferich,et al.  Mechanisms of polymer degradation and erosion. , 1996, Biomaterials.

[94]  H. Winet,et al.  Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers. , 1996, Biomaterials.

[95]  C. M. Agrawal,et al.  Salient Degradation Features of a 50:50 PLA/PGA Scaffold for Tissue Engineering. , 1996, Tissue engineering.

[96]  R Langer,et al.  Tissue engineering: biomedical applications. , 1995, Tissue engineering.

[97]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[98]  R Langer,et al.  Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. , 1993, Journal of biomedical materials research.

[99]  Jeffrey A. Hubbell,et al.  Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers , 1993 .