Slowed information processing in multiple sclerosis.

Sixteen patients with a definitive diagnosis of multiple sclerosis (MS) and an equal number of matched controls were administered tests of memory and information processing speed. Results indicated a significant long-term verbal memory impairment in patients with MS, with spared short-term memory and memory scanning. Speed of information processing was evaluated with the Paced Auditory Serial Addition Test. The results for the two highest rates of presentation revealed significantly impaired processing in the MS group. Performance at the higher rates and retrieval of information from long-term memory were significantly correlated. These results suggest that slowed information processing is a deficit that contributes to long-term memory impairment in patients with MS.

[1]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[2]  I Grant,et al.  Deficient learning and memory in early and middle phases of multiple sclerosis. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[3]  Benson Df.  Subcortical dementia: a clinical approach. , 1983, Advances in neurology.

[4]  M. Albert,et al.  The `subcortical dementia' of progressive supranuclear palsy , 1974, Journal of neurology, neurosurgery, and psychiatry.

[5]  R. Medaer,et al.  Intellectual impairment in multiple sclerosis , 1984 .

[6]  D. Silberberg,et al.  New diagnostic criteria for multiple sclerosis: Guidelines for research protocols , 1983, Annals of neurology.

[7]  J. Charcot.  Lectures on the diseases of the nervous system: delivered at La Salpêtrìere , 2010 .

[8]  P. Rubé,et al.  L’examen Clinique en Psychologie , 1959 .

[9]  M. Carroll,et al.  Memory impairment in multiple sclerosis , 1984, Neuropsychologia.

[10]  T. Hammeke,et al.  Memory disturbance in chronic progressive multiple sclerosis. , 1984, Archives of neurology.

[11]  G. Paulson,et al.  The concept of subcortical dementia. , 1985, The American journal of psychiatry.

[12]  P. A. Beatty,et al.  NEUROPSYCHOLOGICAL ASPECTS OF MULTIPLE SCLEROSIS , 1977, The Journal of nervous and mental disease.

[13]  J. Kurtzke.  Rating neurologic impairment in multiple sclerosis , 1983, Neurology.

[14]  S. Sternberg.  High-Speed Scanning in Human Memory , 1966, Science.

[15]  K. Jambor.  Cognitive Functioning in Multiple Sclerosis , 1969, British Journal of Psychiatry.

[16]  D. Gronwall,et al.  The psychological effects of concussion , 1974 .