Emerging roles of Toll-like receptor 9 in cardiometabolic disorders
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[1] B. Arneth. Systemic Lupus Erythematosus and DNA Degradation and Elimination Defects , 2019, Front. Immunol..
[2] K. Otsu,et al. Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice , 2019, JACC. Basic to translational science.
[3] B. Duvvuri,et al. Cell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases , 2019, Front. Immunol..
[4] T. Akasaka,et al. Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis , 2019, Journal of the American Heart Association.
[5] Y. Higashikuni,et al. Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia , 2018, Front. Cardiovasc. Med..
[6] 齋藤 義修. DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway , 2018 .
[7] D. Cram,et al. High levels of circulating cell‐free DNA are a biomarker of active SLE , 2018, European journal of clinical investigation.
[8] T. Kodama,et al. DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway , 2018, Cell Death & Differentiation.
[9] S. Grazioli,et al. Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases , 2018, Front. Immunol..
[10] J. Lyu,et al. Plasma‐derived exosomes contribute to inflammation via the TLR9‐NF‐&kgr;B pathway in chronic heart failure patients , 2017, Molecular immunology.
[11] L. Bryzgalov,et al. Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers , 2017, Arthritis Research & Therapy.
[12] L. Pączek,et al. The role and diagnostic value of cell-free DNA in systemic lupus erythematosus. , 2017, Clinical and experimental rheumatology.
[13] R. Arbeit,et al. IMO-8400, a toll-like receptor 7, 8, and 9 antagonist, demonstrates clinical activity in a phase 2a, randomized, placebo-controlled trial in patients with moderate-to-severe plaque psoriasis. , 2017, Clinical immunology.
[14] A. Engin. Adipocyte-Macrophage Cross-Talk in Obesity. , 2017, Advances in experimental medicine and biology.
[15] S. Alavian,et al. Liver Mitochondrial DNA Copy Number and Deletion Levels May Contribute to Nonalcoholic Fatty Liver Disease Susceptibility , 2016, Hepatitis monthly.
[16] N. Pace,et al. The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis , 2016, International journal of inflammation.
[17] C. Liu,et al. Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance. , 2016, Cell reports.
[18] I. Seljeflot,et al. Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes , 2016, Basic Research in Cardiology.
[19] I. Imoto,et al. Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance , 2016, Science Advances.
[20] R. Coffman,et al. Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. , 2016, The Journal of clinical investigation.
[21] S. Zimmer,et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice , 2016, PloS one.
[22] You-Me Kim,et al. TLR9 regulates adipose tissue inflammation and obesity‐related metabolic disorders , 2015, Obesity.
[23] M. Clément,et al. CD4+CXCR3+ T cells and plasmacytoid dendritic cells drive accelerated atherosclerosis associated with systemic lupus erythematosus. , 2015, Journal of autoimmunity.
[24] Ling Lin,et al. Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE−/− Mice , 2015, Disease markers.
[25] T. Gould,et al. Extracellular DNA and histones: double‐edged swords in immunothrombosis , 2015, Journal of thrombosis and haemostasis : JTH.
[26] S. Subramanian,et al. Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet , 2015, Nutrition & Diabetes.
[27] L. Velloso,et al. TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation. , 2015, Endocrine reviews.
[28] Daniel Konrad,et al. The gut-adipose-liver axis in the metabolic syndrome. , 2014, Physiology.
[29] Taro Kawai,et al. Toll-Like Receptor Signaling Pathways , 2014, Front. Immunol..
[30] F. Perez-Vizcaino,et al. Chronic Hydroxychloroquine Improves Endothelial Dysfunction and Protects Kidney in a Mouse Model of Systemic Lupus Erythematosus , 2014, Hypertension.
[31] A. Dick,et al. TLR9 agonist regulates angiogenesis and inhibits corneal neovascularization. , 2014, The American journal of pathology.
[32] J. Kalbfleisch,et al. The TLR9 Ligand, CpG‐ODN, Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of PI3K/Akt Signaling , 2014, Journal of the American Heart Association.
[33] S. Akira,et al. Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice , 2014, Arteriosclerosis, thrombosis, and vascular biology.
[34] F. Villarroya,et al. Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in β-cells , 2014, International Journal of Obesity.
[35] Guochun Wang,et al. Elevated plasma cfDNA may be associated with active lupus nephritis and partially attributed to abnormal regulation of neutrophil extracellular traps (NETs) in patients with systemic lupus erythematosus. , 2014, Internal medicine.
[36] Y. Higashikuni,et al. HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9. , 2013, Atherosclerosis.
[37] K. Otsu,et al. Translation of hemodynamic stress to sterile inflammation in the heart , 2013, Trends in Endocrinology & Metabolism.
[38] J. Rutledge,et al. Inflammasome-Mediated Secretion of IL-1β in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids , 2013, The Journal of Immunology.
[39] T. Zuo,et al. Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke , 2013, Neuroscience Letters.
[40] H. Crijns,et al. Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State , 2013, Arteriosclerosis, thrombosis, and vascular biology.
[41] R. Flavell,et al. Innate sensors of pathogen and stress: linking inflammation to obesity. , 2013, The Journal of allergy and clinical immunology.
[42] C. Monaco,et al. Toll-Like Receptors in Atherosclerosis , 2013, International journal of molecular sciences.
[43] A. Bowie,et al. Immune sensing of DNA. , 2013, Immunity.
[44] T. Pawson,et al. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. , 2013, Cell metabolism.
[45] A. Bennakhi,et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation , 2012, Journal of Inflammation.
[46] P. Libby. Inflammation in Atherosclerosis , 2012, Arteriosclerosis, thrombosis, and vascular biology.
[47] J. Hamming,et al. Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and Migration , 2012, Arteriosclerosis, thrombosis, and vascular biology.
[48] S. Akira,et al. Mitochondrial DNA That Escapes from Autophagy Causes Inflammation and Heart Failure , 2012, Nature.
[49] A. Fairhurst,et al. TLR7 and TLR9 in SLE: when sensing self goes wrong , 2012, Immunologic research.
[50] G. Shulman,et al. Mechanisms for Insulin Resistance: Common Threads and Missing Links , 2012, Cell.
[51] T. Weichhart,et al. Apoptotic cell-free DNA promotes inflammation in haemodialysis patients. , 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[52] S. Devaraj,et al. Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome , 2012, Diabetes Care.
[53] Seung‐Jin Kim,et al. Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice. , 2012, The Journal of nutritional biochemistry.
[54] Yue Zheng,et al. Damage-Associated Molecular Patterns , and Sterile Inflammation in Cardiovascular Disease , 2011 .
[55] J. Bargman,et al. The role of antimalarial agents in the treatment of SLE and lupus nephritis , 2011, Nature Reviews Nephrology.
[56] P. Doevendans,et al. Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis. , 2011, Clinical science.
[57] P. Sansonetti,et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment , 2011, EMBO molecular medicine.
[58] M. Fresno,et al. Toll-like receptors, inflammation, metabolism and obesity , 2011, Archives of physiology and biochemistry.
[59] D. Schrijvers,et al. Necrotic cell death in atherosclerosis , 2011, Basic Research in Cardiology.
[60] U. Švajger,et al. Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines , 2011, The Journal of Immunology.
[61] S. Tangye,et al. Inflammatory Mechanisms in Obesity , 2013 .
[62] Chad A. Cowan,et al. Rapid Cellular Turnover in Adipose Tissue , 2011, PloS one.
[63] Jeremy E. Davis,et al. Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes. , 2011, The Journal of nutritional biochemistry.
[64] K. Peter,et al. High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice , 2011, Arteriosclerosis, thrombosis, and vascular biology.
[65] A. C. Könner,et al. Toll-like receptors: linking inflammation to metabolism , 2011, Trends in Endocrinology & Metabolism.
[66] N. Tsuchimori,et al. TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules , 2011, Molecular Pharmacology.
[67] M. Bagot,et al. IL‐10 produced by activated human B cells regulates CD4+ T‐cell activation in vitro , 2010, European journal of immunology.
[68] Jon Cohen,et al. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis* , 2010, Critical care medicine.
[69] T. Suganami,et al. Adipose tissue macrophages: their role in adipose tissue remodeling , 2010, Journal of leukocyte biology.
[70] D. Brenner,et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. , 2010, Gastroenterology.
[71] S. Akira,et al. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors , 2010, Nature Immunology.
[72] R. Sorrentino,et al. The activation of liver X receptors inhibits toll‐like receptor‐9‐induced foam cell formation , 2010, Journal of cellular physiology.
[73] P. J. Pretorius,et al. Is the role of circulating DNA as a biomarker of cancer being prematurely overrated? , 2010, Clinical biochemistry.
[74] J. Tanus-Santos,et al. Circulating cell-free DNA levels in plasma increase with severity in experimental acute pulmonary thromboembolism. , 2009, Clinica chimica acta; international journal of clinical chemistry.
[75] S. Bombardieri,et al. Cell-free DNA in the plasma of patients with systemic sclerosis , 2009, Clinical Rheumatology.
[76] S. Schinner,et al. Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications , 2009 .
[77] S. Baek,et al. A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation. , 2008, Cellular signalling.
[78] G. Hotamisligil,et al. Nutrient sensing and inflammation in metabolic diseases , 2008, Nature Reviews Immunology.
[79] S. Akira,et al. Excessive CpG 1668 stimulation triggers IL‐10 production by cDC that inhibits IFN‐α responses by pDC , 2008, European journal of immunology.
[80] M. Gilliet,et al. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases , 2008, Nature Reviews Immunology.
[81] T. Kaisho,et al. Turning NF-kappaB and IRFs on and off in DC. , 2008, Trends in immunology.
[82] E. Ruokonen,et al. Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock. , 2008, Clinical chemistry.
[83] R. Coffman,et al. Treatment of lupus‐prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms , 2007, European journal of immunology.
[84] K. Strissel,et al. Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications , 2007, Diabetes.
[85] G. Ertl,et al. Mechanisms of Disease: Toll-like receptors in cardiovascular disease , 2007, Nature Clinical Practice Cardiovascular Medicine.
[86] S. Baek,et al. Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression , 2007, Experimental & Molecular Medicine.
[87] Vishnu Swarup,et al. Circulating (cell‐free) nucleic acids – A promising, non‐invasive tool for early detection of several human diseases , 2007, FEBS letters.
[88] G. Hotamisligil,et al. Inflammation and metabolic disorders , 2006, Nature.
[89] E. Chaikof,et al. Pathogen-Sensing Plasmacytoid Dendritic Cells Stimulate Cytotoxic T-Cell Function in the Atherosclerotic Plaque Through Interferon-&agr; , 2006, Circulation.
[90] K. Walley,et al. Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. , 2006, Cardiovascular research.
[91] A. Marshak‐Rothstein. Toll-like receptors in systemic autoimmune disease , 2006, Nature Reviews Immunology.
[92] A. Goldfine,et al. Inflammation and insulin resistance. , 2006, The Journal of clinical investigation.
[93] S. Akira,et al. Pathogen Recognition and Innate Immunity , 2006, Cell.
[94] T. Suganami,et al. A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor α , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[95] Shizuo Akira,et al. Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1 , 2005, The Journal of Immunology.
[96] P. Iyengar,et al. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy , 2005, Nature Medicine.
[97] Morihiro Matsuda,et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. , 2004, The Journal of clinical investigation.
[98] Shizuo Akira,et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses , 2004, Nature Immunology.
[99] B. Monks,et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome , 2004, Nature Immunology.
[100] T. Littlewood,et al. Apoptotic cell death in atherosclerosis , 2003, Current Opinion in Lipidology.
[101] Hilde van der Togt,et al. Publisher's Note , 2003, J. Netw. Comput. Appl..
[102] Peter Libby,et al. Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis , 2002, Circulation research.
[103] G. Hansson,et al. Expression of Toll-Like Receptors in Human Atherosclerotic Lesions: A Possible Pathway for Plaque Activation , 2002, Circulation.
[104] A. Krieg,et al. CpG motifs in bacterial DNA and their immune effects. , 2002, Annual review of immunology.
[105] M. Fishbein,et al. Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL , 2001, Circulation.
[106] S. Akira,et al. A Toll-like receptor recognizes bacterial DNA , 2000, Nature.
[107] H. Oral,et al. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). , 1996, Journal of the American College of Cardiology.
[108] J. Isner,et al. Apoptosis in human atherosclerosis and restenosis. , 1995, Circulation.
[109] D. A. Clayton,et al. Pervasive CpG suppression in animal mitochondrial genomes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[110] M. Szyf,et al. Methylation pattern of mouse mitochondrial DNA. , 1984, Nucleic acids research.
[111] P. Schur,et al. Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. , 1966, The Journal of clinical investigation.