Models of higher-order structure: foldamers and beyond.

Folding, an attribute common to biological macromolecules such as proteins and nucleic acids, enables the formation of complex three-dimensional structure and thus enables the function of these exquisite molecular machines. Chemists are exploring the folding of natural and artificial systems with increasing enthusiasm and boldness of molecular design. The most recent achievements in the area of artificial folding molecules are described in this review.

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