Discovery of a new dendritic cell subset derived from immature granulocytes

iii DEDICATION v ACKNOWLEDGEMENT vi CONTENTS viii LIST OF ABBREVIATIONS ix INTRODUCTION 1 LITERATURE REVIEW 5 MATERIALS AND METHODS 34 RESULTS 46 DISCUSSION 79 SUMMARY 90 REFERENCES 91

[1]  D. Kaplan.  In vivo function of Langerhans cells and dermal dendritic cells. , 2010, Trends in immunology.

[2]  R. Steinman,et al.  Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas , 2010, Cell.

[3]  B. Holzmann,et al.  LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. , 2010, Blood.

[4]  S. Rankin,et al.  Neutrophil kinetics in health and disease , 2010, Trends in immunology.

[5]  B. Chambers,et al.  Plasmacytoid dendritic cell‐induced migration and activation of NK cells in vivo , 2010, European journal of immunology.

[6]  Y. Ogawa,et al.  Intravital imaging of IL-1beta production in skin. , 2010, The Journal of investigative dermatology.

[7]  C. Kurts,et al.  Cross-priming in health and disease , 2010, Nature Reviews Immunology.

[8]  B. Weiss-Steider,et al.  Sodium caseinate induces secretion of macrophage colony-stimulating factor from neutrophils. , 2010, Immunobiology.

[9]  E. Devilard,et al.  Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells. , 2010, Blood.

[10]  A. Flisser,et al.  Dendritic Cells in the Gut: Interaction with Intestinal Helminths , 2010, Journal of biomedicine & biotechnology.

[11]  M. Nussenzweig,et al.  Origin and development of dendritic cells , 2010, Immunological reviews.

[12]  S. Boddupalli,et al.  Instructive cytokine signals in dendritic cell lineage commitment , 2010, Immunological reviews.

[13]  F. Ginhoux,et al.  The origin and development of nonlymphoid tissue CD103+ DCs , 2009, The Journal of experimental medicine.

[14]  H. Matsushima,et al.  IL‐33 promotes DC development in BM culture by triggering GM‐CSF production , 2009, European journal of immunology.

[15]  Leesun Kim,et al.  Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. , 2009, Immunity.

[16]  K. Bhoola,et al.  Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease‐9 and myeloperoxidase in human neutrophils: involvement of mitogen‐activated protein kinase family , 2009, Journal of leukocyte biology.

[17]  E. Unanue,et al.  Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation , 2009, Proceedings of the National Academy of Sciences.

[18]  H. Matsushima,et al.  Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells. , 2009, Cancer research.

[19]  John R. Ledford,et al.  A TLR2 Agonist in German Cockroach Frass Activates MMP-9 Release and Is Protective against Allergic Inflammation in Mice1 , 2009, The Journal of Immunology.

[20]  O. Soehnlein.  Direct and alternative antimicrobial mechanisms of neutrophil-derived granule proteins , 2009, Journal of Molecular Medicine.

[21]  L. Lanier,et al.  Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction , 2009, The Journal of experimental medicine.

[22]  A. Brooks,et al.  Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells , 2009, Nature Immunology.

[23]  A. Rudensky,et al.  In Vivo Analysis of Dendritic Cell Development and Homeostasis , 2009, Science.

[24]  Miriam Merad,et al.  Dendritic cell homeostasis. , 2009, Blood.

[25]  C. Münz,et al.  Dendritic Cell Interactions with NK Cells from Different Tissues , 2009, Journal of Clinical Immunology.

[26]  C. Harding,et al.  MHC molecules and microbial antigen processing in phagosomes. , 2009, Current opinion in immunology.

[27]  L. O’Neill,et al.  The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress , 2008, Immunological reviews.

[28]  Hossam Ebaid,et al.  Upregulation of major histocompatibility complex class II, CD83, CD64, and CD14 on polymorphonuclear neutrophils stimulated with interleukin-15. , 2008, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[29]  F. Ginhoux,et al.  Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells , 2008, Nature Reviews Immunology.

[30]  J. Blander.  Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors , 2008, Annals of the rheumatic diseases.

[31]  E. Unanue,et al.  Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity , 2008, Science.

[32]  L. Zitvogel,et al.  Killer dendritic cells: IKDC and the others. , 2008, Current opinion in immunology.

[33]  U. V. von Andrian,et al.  Mechanisms and consequences of dendritic cell migration. , 2008, Immunity.

[34]  W. Liles,et al.  The phagocytes: neutrophils and monocytes. , 2008, Blood.

[35]  Hidde L. Ploegh,et al.  The known unknowns of antigen processing and presentation , 2008, Nature Reviews Immunology.

[36]  P. Schneider,et al.  Intestinal Bacteria Condition Dendritic Cells to Promote IgA Production , 2008, PloS one.

[37]  J. Hamilton.  Colony-stimulating factors in inflammation and autoimmunity , 2008, Nature Reviews Immunology.

[38]  A. Di Nardo,et al.  Mast Cell Cathelicidin Antimicrobial Peptide Prevents Invasive Group A Streptococcus Infection of the Skin1 , 2008, The Journal of Immunology.

[39]  J. Villadangos,et al.  The cell biology of cross‐presentation and the role of dendritic cell subsets , 2008, Immunology and cell biology.

[40]  I. Mellman,et al.  Spinophilin participates in information transfer at immunological synapses , 2008, The Journal of cell biology.

[41]  Ken Jacobson,et al.  Distribution and lateral mobility of DC-SIGN on immature dendritic cells–implications for pathogen uptake , 2008, Journal of Cell Science.

[42]  T. Elliott,et al.  Molecular machinations of the MHC-I peptide loading complex. , 2008, Current opinion in immunology.

[43]  M. Hornef,et al.  Developmental switch of intestinal antimicrobial peptide expression , 2008, The Journal of experimental medicine.

[44]  F. Ginhoux,et al.  Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state , 2007, The Journal of experimental medicine.

[45]  K. Hogquist,et al.  Identification of a novel population of Langerin+ dendritic cells , 2007, The Journal of experimental medicine.

[46]  E. Devilard,et al.  The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells , 2007, The Journal of experimental medicine.

[47]  G. Hanna,et al.  Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity. , 2007, Blood.

[48]  Michael B. Brenner,et al.  CD1 antigen presentation: how it works , 2007, Nature Reviews Immunology.

[49]  Yuekang Xu,et al.  Differential Development of Murine Dendritic Cells by GM-CSF versus Flt3 Ligand Has Implications for Inflammation and Trafficking1 , 2007, The Journal of Immunology.

[50]  P. Crocker,et al.  Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection , 2007, International immunology.

[51]  Melanie Bahlo,et al.  Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo , 2007, Nature Immunology.

[52]  V. Barnaba,et al.  Neutrophils efficiently cross-prime naive T cells in vivo. , 2007, Blood.

[53]  D. Jarrossay,et al.  Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow , 2007, Nature Immunology.

[54]  R. Steinman,et al.  Taking dendritic cells into medicine , 2007, Nature.

[55]  W. Paul.  Dendritic Cells Bask in the Limelight , 2007, Cell.

[56]  N. Borregaard,et al.  Neutrophil granules: a library of innate immunity proteins. , 2007, Trends in immunology.

[57]  K. Hirata,et al.  Efficient Cross-Presentation by Heat Shock Protein 90-Peptide Complex-Loaded Dendritic Cells via an Endosomal Pathway , 2007, The Journal of Immunology.

[58]  J. Villadangos,et al.  Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo , 2007, Nature Reviews Immunology.

[59]  Yong‐jun Liu,et al.  Development of dendritic-cell lineages. , 2007, Immunity.

[60]  P. Roché.  Faculty Opinions recommendation of Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. , 2007 .

[61]  M. Nussenzweig,et al.  Origin of dendritic cells in peripheral lymphoid organs of mice , 2007, Nature Immunology.

[62]  E. Gilboa.  DC-based cancer vaccines. , 2007, The Journal of clinical investigation.

[63]  Sven Burgdorf,et al.  Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation , 2007, Science.

[64]  I. Mellman,et al.  Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination , 2006, Nature.

[65]  H. Ploegh,et al.  Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover. , 2006, The Journal of investigative dermatology.

[66]  T. Hökfelt,et al.  Induction of the Antimicrobial Peptide CRAMP in the Blood-Brain Barrier and Meninges after Meningococcal Infection , 2006, Infection and Immunity.

[67]  M. Idzko,et al.  IL‐6 and IL‐8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids , 2006, Journal of leukocyte biology.

[68]  G. Raposo,et al.  NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells , 2006, Cell.

[69]  G. Belz,et al.  The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[70]  G. Woods,et al.  Neonatal exposure to UV‐B radiation leads to a large reduction in Langerhans cell density, but by maturity, there is an enhanced ability of dendritic cells to stimulate T cells , 2006, Immunology and cell biology.

[71]  Li Wu,et al.  Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes , 2006, Nature Immunology.

[72]  R. Medzhitov,et al.  Toll-dependent selection of microbial antigens for presentation by dendritic cells , 2006, Nature.

[73]  J. Connolly,et al.  Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. , 2006, Blood.

[74]  T. Moran,et al.  Toll-Like Receptor-Independent Triggering of Dendritic Cell Maturation by Viruses , 2006, Journal of Virology.

[75]  Carl Nathan,et al.  Neutrophils and immunity: challenges and opportunities , 2006, Nature Reviews Immunology.

[76]  I. Weissman,et al.  Flk2+ myeloid progenitors are the main source of Langerhans cells. , 2006, Blood.

[77]  B. Porse,et al.  Systems biology of neutrophil differentiation and immune response. , 2006, Current opinion in immunology.

[78]  L. Lanier,et al.  Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity , 2006, Nature Medicine.

[79]  P. Opolon,et al.  A novel dendritic cell subset involved in tumor immunosurveillance , 2006, Nature Medicine.

[80]  F. Ginhoux,et al.  Langerhans cells arise from monocytes in vivo , 2006, Nature Immunology.

[81]  Ana Cumano,et al.  A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells , 2006, Science.

[82]  Y. Ogawa,et al.  Discovery of novel immunostimulants by dendritic-cell-based functional screening. , 2005, Blood.

[83]  Osamu Takeuchi,et al.  IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction , 2005, Nature Immunology.

[84]  Peter Cresswell,et al.  Mechanisms of MHC class I‐restricted antigen processing and cross‐presentation , 2005, Immunological reviews.

[85]  D. Accapezzato,et al.  Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo , 2005, The Journal of experimental medicine.

[86]  T. Honjo,et al.  Involvement of Fractalkine/CX3CL1 Expression by Dendritic Cells in the Enhancement of Host Immunity against Legionella pneumophila , 2005, Infection and Immunity.

[87]  P. Morel,et al.  Polarization of naive T cells into Th1 or Th2 by distinct cytokine‐driven murine dendritic cell populations: implications for immunotherapy , 2005, Journal of leukocyte biology.

[88]  S. Chakrabarti,et al.  Regulation of matrix metalloproteinase‐9 release from IL‐8‐stimulated human neutrophils , 2005, Journal of leukocyte biology.

[89]  P. Perrin,et al.  Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. , 2005, Immunity.

[90]  T. Geijtenbeek,et al.  Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN , 2005, The Journal of experimental medicine.

[91]  Soumaya Bennouna,et al.  Microbial Antigen Triggers Rapid Mobilization of TNF-α to the Surface of Mouse Neutrophils Transforming Them into Inducers of High-Level Dendritic Cell TNF-α Production1 , 2005, The Journal of Immunology.

[92]  L. Joosten,et al.  Transdifferentiation of polymorphonuclear neutrophils to dendritic-like cells at the site of inflammation in rheumatoid arthritis: evidence for activation by T cells , 2005, Annals of the rheumatic diseases.

[93]  Henry C. Chang,et al.  Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate , 2005, Science.

[94]  Hidde L Ploegh,et al.  CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance , 2005, Science.

[95]  Jose L Pruneda-Paz,et al.  Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection , 2004, Nature Immunology.

[96]  J. Harty,et al.  Neutrophil Involvement in Cross-Priming CD8+ T Cell Responses to Bacterial Antigens1 , 2004, The Journal of Immunology.

[97]  K. Rock,et al.  Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. , 2004, Immunity.

[98]  N. Delaleu,et al.  Interleukin-1 beta and interleukin-18: regulation and activity in local inflammation. , 2004, Periodontology 2000.

[99]  Qingsheng Li,et al.  Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation1 , 2004, The Journal of Immunology.

[100]  Li Wu,et al.  Development of dendritic cell system. , 2004, Cellular & molecular immunology.

[101]  L. Costa,et al.  The induction of MMP-9 release from granulocytes by vitamin E in UHMWPE. , 2004, Biomaterials.

[102]  T. Cover,et al.  Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. , 2003, Blood.

[103]  R. Flavell,et al.  STAT3 is required for Flt3L-dependent dendritic cell differentiation. , 2003, Immunity.

[104]  T. Curiel,et al.  Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection 1 , 2003, The Journal of Immunology.

[105]  M. Kapsenberg.  Dendritic-cell control of pathogen-driven T-cell polarization , 2003, Nature Reviews Immunology.

[106]  N. Borregaard,et al.  Neutrophil granules and secretory vesicles in inflammation. , 2003, Microbes and infection.

[107]  Adil I. Khan,et al.  L-Selectin Ligands in Lymphoid Tissues and Models of Inflammation , 2003, Inflammation.

[108]  C. Leclerc,et al.  In Vivo, Dendritic Cells Can Cross-Present Virus-Like Particles Using an Endosome-to-Cytosol Pathway 1 , 2003, The Journal of Immunology.

[109]  M. Jenkins,et al.  Antigen presentation to naive CD4 T cells in the lymph node , 2003, Nature Immunology.

[110]  A. D'amico,et al.  The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid Predendritic Cells Are within the Bone Marrow Hemopoietic Precursors Expressing Flt3 , 2003, The Journal of experimental medicine.

[111]  R. Steinman,et al.  Activation of Natural Killer T Cells by -Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein , 2003 .

[112]  Steffen Jung,et al.  Blood monocytes consist of two principal subsets with distinct migratory properties. , 2003, Immunity.

[113]  C. Ardavı́n.  Origin, precursors and differentiation of mouse dendritic cells , 2003, Nature Reviews Immunology.

[114]  E. Pamer,et al.  TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. , 2003, Immunity.

[115]  E. Clark,et al.  Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF. , 2003, Blood.

[116]  M. Brenner,et al.  IL-6 Production by Pulmonary Dendritic Cells Impedes Th1 Immune Responses 1 , 2003, The Journal of Immunology.

[117]  G. Belz,et al.  Cutting Edge: Conventional CD8α+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-11 , 2003, The Journal of Immunology.

[118]  I. Mellman,et al.  Activation of Lysosomal Function During Dendritic Cell Maturation , 2003, Science.

[119]  P. Hertzog,et al.  Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors. , 2003, Blood.

[120]  L. Brown,et al.  Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus , 2003, Immunology and cell biology.

[121]  H. Geuze,et al.  MHC Class II Compartments in Human Dendritic Cells Undergo Profound Structural Changes Upon Activation , 2002, Traffic.

[122]  K. Andrassy,et al.  Up‐regulation of the dendritic cell marker CD83 on polymorphonuclear neutrophils (PMN): divergent expression in acute bacterial infections and chronic inflammatory disease , 2002, Clinical and Experimental Immunology.

[123]  H. Macdonald,et al.  Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage. , 2002, Blood.

[124]  D. Tough,et al.  Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. , 2002, Blood.

[125]  Steffen Jung,et al.  In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. , 2002, Immunity.

[126]  Taku Sato,et al.  Identification of CD8alpha+CD11c- lineage phenotype-negative cells in the spleen as committed precursor of CD8alpha+ dendritic cells. , 2002, Blood.

[127]  J. Cyster,et al.  Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis1 , 2002, The Journal of Immunology.

[128]  R. Germain,et al.  Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes , 2002, Science.

[129]  S. Rafii,et al.  Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand , 2002, Cell.

[130]  C. Figdor,et al.  C-type lectin receptors on dendritic cells and langerhans cells , 2002, Nature Reviews Immunology.

[131]  F. Lechner,et al.  Cross‐presentation of virus‐like particles by skin‐derived CD8– dendritic cells: a dispensable role for TAP , 2002, European journal of immunology.

[132]  D. Kuhns,et al.  Thioglycollate peritonitis in mice lacking C5, 5‐lipoxygenase, or p47phox: complement, leukotrienes, and reactive oxidants in acute inflammation , 2002, Journal of leukocyte biology.

[133]  Yong‐jun Liu,et al.  Mouse and human dendritic cell subtypes , 2002, Nature Reviews Immunology.

[134]  C. Arias,et al.  Characterization of a common precursor population for dendritic cells , 2002, Nature.

[135]  A. D'amico,et al.  Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. , 2001, Blood.

[136]  Marc Dalod,et al.  Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology , 2001, Nature Immunology.

[137]  Takaaki Ohtake,et al.  Innate antimicrobial peptide protects the skin from invasive bacterial infection , 2001, Nature.

[138]  A. Lanzavecchia,et al.  Mouse pre‐immunocytes as non‐proliferating multipotent precursors of macrophages, interferon‐producing cells, CD8α+ and CD8α– dendritic cells , 2001 .

[139]  Jacques Neefjes,et al.  The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors , 2001, Current Biology.

[140]  Kenneth Huttner,et al.  Processing site and gene structure for the murine antimicrobial peptide CRAMP , 2001, Peptides.

[141]  C. Elmets,et al.  The role of ICAM‐1 molecule in the migration of Langerhans cells in the skin and regional lymph node , 2001, European journal of immunology.

[142]  P. E. Van den Steen,et al.  Gelatinase B: a tuner and amplifier of immune functions. , 2001, Trends in immunology.

[143]  B. Weiss-Steider,et al.  Granulocyte colony-stimulating factor induces neutrophils to secrete macrophage colony-stimulating factor. , 2001, Cytokine.

[144]  Y. Liu,et al.  Dendritic Cell Subsets and Lineages, and Their Functions in Innate and Adaptive Immunity , 2001, Cell.

[145]  D. Umetsu,et al.  Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen , 2001, Nature Immunology.

[146]  C. Benoist,et al.  The Dendritic Cell Populations of Mouse Lymph Nodes1 , 2001, The Journal of Immunology.

[147]  I. Weissman,et al.  Dendritic cell potentials of early lymphoid and myeloid progenitors. , 2001, Blood.

[148]  P. Srivastava,et al.  CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. , 2001, Immunity.

[149]  P. Godowski,et al.  Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 21 , 2001, The Journal of Immunology.

[150]  K. Nakamura,et al.  Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. , 2001, Biochemical and biophysical research communications.

[151]  M. Kronenberg,et al.  Presentation of self and microbial lipids by CD1 molecules. , 2001, Current opinion in immunology.

[152]  A. Bendelac,et al.  CD1 and lipid antigens: intracellular pathways for antigen presentation. , 2001, Current opinion in immunology.

[153]  G. Seymour,et al.  Cytokines in periodontal disease: where to from here? , 2001, Acta odontologica Scandinavica.

[154]  K. Rock,et al.  Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[155]  A. D'amico,et al.  The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations , 2000, The Journal of Immunology.

[156]  W. Gong,et al.  Expression of CCR6 and CD83 by cytokine-activated human neutrophils. , 2000, Blood.

[157]  K. Rock,et al.  Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation , 2000, The Journal of experimental medicine.

[158]  F. Facchetti,et al.  The plasmacytoid monocyte: from morphology to function. , 2000, Advances in clinical pathology : the official journal of Adriatic Society of Pathology.

[159]  A. Aderem,et al.  Toll-like receptors in the induction of the innate immune response , 2000, Nature.

[160]  H. Rammensee,et al.  The heat shock protein gp96 induces maturation of dendritic cells and down‐regulation of its receptor , 2000, European journal of immunology.

[161]  B. Pulendran,et al.  Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. , 2000, Blood.

[162]  G. Macpherson,et al.  Dendritic cell–B‐cell interaction: dendritic cells provide B cells with CD40‐independent proliferation signals and CD40‐dependent survival signals , 2000, Immunology.

[163]  Douglas S Kwon,et al.  DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells , 2000, Cell.

[164]  G. Halliday,et al.  Langerhans cells migrate to local lymph nodes following cutaneous infection with an arbovirus. , 2000, The Journal of investigative dermatology.

[165]  P. Cresswell,et al.  The nature of the MHC class I peptide loading complex , 1999, Immunological reviews.

[166]  R. Steinman,et al.  Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. , 1999, Immunity.

[167]  M. Foti,et al.  Early events in dendritic cell maturation induced by LPS. , 1999, Microbes and infection.

[168]  Sebastian Amigorena,et al.  Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells , 1999, Nature Cell Biology.

[169]  C. Figdor,et al.  Generation and functional characterization of mouse monocyte‐derived dendritic cells , 1999, European journal of immunology.

[170]  G. Hartmann,et al.  CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[171]  L. Williams,et al.  Secondary lymphoid-tissue chemokine (SLC) is chemotactic for mature dendritic cells. , 1999, Blood.

[172]  T. Honjo,et al.  Fractalkine and macrophage‐derived chemokine: T cell‐attracting chemokines expressed in T cell area dendritic cells , 1999, European journal of immunology.

[173]  K. Andrassy,et al.  Expression of major histocompatibility class II antigens on polymorphonuclear neutrophils in patients with Wegener's granulomatosis. , 1999, Kidney international.

[174]  M. Foti,et al.  Coordinated events during bacteria-induced DC maturation. , 1999, Immunology today.

[175]  A. Ohta,et al.  The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells , 1999, The Journal of experimental medicine.

[176]  Hanno Langen,et al.  Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA , 1999, The Journal of experimental medicine.

[177]  R. Maldonado-López,et al.  CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo , 1999, The Journal of experimental medicine.

[178]  R. Steinman,et al.  Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells , 1998, The Journal of experimental medicine.

[179]  P. Ricciardi-Castagnoli,et al.  Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. , 1998, Journal of immunology.

[180]  R. Offringa,et al.  Cross-priming of CTL responses in vivo does not require antigenic peptides in the endoplasmic reticulum of immunizing cells. , 1998, Journal of immunology.

[181]  Loise M. Francisco,et al.  Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes , 1998, The Journal of experimental medicine.

[182]  Y. Yamaguchi,et al.  EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. , 1998, Journal of immunology.

[183]  J. Banchereau,et al.  Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. , 1998, Journal of immunology.

[184]  S. Gordon,et al.  Recognizing death: the phagocytosis of apoptotic cells. , 1998, Trends in cell biology.

[185]  J. Banchereau,et al.  A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. , 1998, Immunity.

[186]  Alan J. Waring,et al.  Activities of LL-37, a Cathelin-Associated Antimicrobial Peptide of Human Neutrophils , 1998, Antimicrobial Agents and Chemotherapy.

[187]  A. Pombo,et al.  Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. , 1998, Journal of immunology.

[188]  C. Caux,et al.  Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites , 1998, The Journal of experimental medicine.

[189]  J. Cyster,et al.  Epstein-Barr Virus–induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells , 1998, The Journal of experimental medicine.

[190]  S. Menon,et al.  Leukocystatin, A New Class II Cystatin Expressed Selectively by Hematopoietic Cells* , 1998, The Journal of Biological Chemistry.

[191]  I. Mellman,et al.  Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells , 1998, Cell.

[192]  P. Ricciardi-Castagnoli,et al.  Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[193]  O. Majdic,et al.  Neutrophil Granulocyte–committed Cells Can Be Driven to Acquire Dendritic Cell Characteristics , 1998, The Journal of experimental medicine.

[194]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[195]  M. Albert,et al.  Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs , 1998, Nature.

[196]  S. Aiba.  Maturation of dendritic cells induced by cytokines and haptens. , 1998, The Tohoku journal of experimental medicine.

[197]  W. Heath,et al.  Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements , 1998, Immunology and cell biology.

[198]  J. Cyster,et al.  A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[199]  Jonathan M. Austyn,et al.  Dendritic cells , 1998, Current opinion in hematology.

[200]  R. Steinman,et al.  TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor , 1997, The Journal of experimental medicine.

[201]  D. Bainton,et al.  The Human Antibacterial Cathelicidin, hCAP-18, Is Synthesized in Myelocytes and Metamyelocytes and Localized to Specific Granules in Neutrophils , 1997 .

[202]  A. Lanzavecchia,et al.  The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells , 1997, European journal of immunology.

[203]  J. Drijfhout,et al.  Mannose receptor‐mediated uptake of antigens strongly enhances HLA class II‐restricted antigen presentation by cultured dendritic cells , 1997, European journal of immunology.

[204]  R. Steinman,et al.  High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes , 1997, The Journal of experimental medicine.

[205]  R. Steinman,et al.  Developmental regulation of MHC class II transport in mouse dendritic cells , 1997, Nature.

[206]  Antonio Lanzavecchia,et al.  Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells , 1997, Nature.

[207]  H. Wigzell,et al.  The Expression of the Gene Coding for the Antibacterial Peptide LL-37 Is Induced in Human Keratinocytes during Inflammatory Disorders* , 1997, The Journal of Biological Chemistry.

[208]  J. Banchereau,et al.  Human Dendritic Cells Skew Isotype Switching of CD40-activated Naive B Cells towards IgA1 and IgA2 , 1997, The Journal of experimental medicine.

[209]  B. Stockinger,et al.  Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells. , 1997, Journal of immunology.

[210]  P. Ricciardi-Castagnoli,et al.  Dendritic cell maturation is required for initiation of the immune response , 1997, Journal of leukocyte biology.

[211]  Francesca Granucci,et al.  Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures , 1997, The Journal of experimental medicine.

[212]  T. Mak,et al.  Costimulation of CD28- T lymphocytes by 4-1BB ligand. , 1997, Journal of immunology.

[213]  A. Dunn,et al.  The influence of granulocyte/macrophage colony‐stimulating factor on dendritic cell levels in mouse lymphoid organs , 1997, European journal of immunology.

[214]  Li Wu,et al.  Dendritic Cell Development in Culture from Thymic Precursor Cells in the Absence of Granulocyte/Macrophage Colony-stimulating Factor , 1996, The Journal of experimental medicine.

[215]  J. Banchereau,et al.  Dendritic cells capable of stimulating T cells in germinal centres , 1996, Nature.

[216]  E. Maraskovsky,et al.  Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified , 1996, The Journal of experimental medicine.

[217]  K. Shortman,et al.  Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny , 1996, The Journal of experimental medicine.

[218]  T. Tedder,et al.  Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. , 1996, Journal of immunology.

[219]  J. Odeberg,et al.  The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. , 1996, European journal of biochemistry.

[220]  Y. Uehara,et al.  A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph , 1996, The Journal of experimental medicine.

[221]  P. Cresswell.  Invariant Chain Structure and MHC Class II Function , 1996, Cell.

[222]  P. A. Peterson,et al.  Antigen‐presenting Function of the Mouse CD1 Molecule a , 1996, Annals of the New York Academy of Sciences.

[223]  T. Bieber,et al.  Activation of human epidermal Langerhans cells by engagement of the high affinity receptor for IgE, Fc epsilon RI. , 1995, Journal of immunology.

[224]  T. Bieber,et al.  Membrane and soluble Fc gamma RII/III modulate the antigen-presenting capacity of murine dendritic epidermal Langerhans cells for IgG-complexed antigens. , 1995, Journal of immunology.

[225]  C Danieli,et al.  Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products , 1995, The Journal of experimental medicine.

[226]  W. Kast,et al.  Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells , 1995, The Journal of experimental medicine.

[227]  P. Pizcueta,et al.  L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites , 1995, The Journal of experimental medicine.

[228]  W. Kast,et al.  MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells. , 1995, Journal of immunology.

[229]  R. Steinman,et al.  The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing , 1995, Nature.

[230]  M. Kovacsovics-Bankowski,et al.  A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules , 1995, Science.

[231]  J. Banchereau,et al.  Activation of human dendritic cells through CD40 cross-linking , 1994, The Journal of experimental medicine.

[232]  Kristin A. Hogquist,et al.  T cell receptor antagonist peptides induce positive selection , 1994, Cell.

[233]  C. Sousa,et al.  Phagocytosis of antigens by Langerhans cells in vitro , 1993, The Journal of experimental medicine.

[234]  H. Moll.  Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis. , 1993, Immunology today.

[235]  R. Steinman,et al.  Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[236]  R. Steinman,et al.  Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor , 1992, The Journal of experimental medicine.

[237]  C. Doerschuk.  The role of CD18-mediated adhesion in neutrophil sequestration induced by infusion of activated plasma in rabbits. , 1992, American journal of respiratory cell and molecular biology.

[238]  Li Wu,et al.  The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells , 1992, The Journal of experimental medicine.

[239]  M. Bevan.  Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay , 1976, The Journal of experimental medicine.

[240]  R. Steinman,et al.  IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE , 1974, The Journal of experimental medicine.

[241]  M. Farquhar,et al.  THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW , 1971, The Journal of experimental medicine.

[242]  G. Cartwright,et al.  Neutrophil kinetics in acute infection. , 1967, The Journal of clinical investigation.

[243]  R. Kizek,et al.  Matrix metalloproteinases. , 2010, Current medicinal chemistry.

[244]  Meredith O'Keeffe,et al.  M-CSF: a novel plasmacytoid and conventional dendritic cell poietin. , 2008, Blood.

[245]  A. Dolganiuc,et al.  The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity. , 2008, Critical reviews in immunology.

[246]  Shalin H. Naik,et al.  Steady-state and inflammatory dendritic-cell development , 2007, Nature Reviews Immunology.

[247]  Soumaya Bennouna,et al.  Microbial antigen triggers rapid mobilization of TNF-alpha to the surface of mouse neutrophils transforming them into inducers of high-level dendritic cell TNF-alpha production. , 2005, Journal of immunology.

[248]  Yong‐jun Liu,et al.  IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. , 2005, Annual review of immunology.

[249]  A. Segal,et al.  How neutrophils kill microbes. , 2005, Annual review of immunology.

[250]  S. Saeland,et al.  Langerin/CD207 sheds light on formation of birbeck granules and their possible function in langerhans cells , 2003, Immunologic research.

[251]  I. Weissman,et al.  Langerhans cells renew in the skin throughout life under steady-state conditions , 2003, Nature Immunology.

[252]  Laurence Zitvogel,et al.  Antigen presentation and T cell stimulation by dendritic cells. , 2002, Annual review of immunology.

[253]  Kirsten van Nierop,et al.  Human follicular dendritic cells: function, origin and development. , 2002, Seminars in immunology.

[254]  W. Heath,et al.  Cross-presentation, dendritic cells, tolerance and immunity. , 2001, Annual review of immunology.

[255]  C Caux,et al.  Immunobiology of dendritic cells. , 2000, Annual review of immunology.

[256]  M. Probst-Kepper,et al.  Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. , 2000, Immunity.

[257]  S. Porcelli,et al.  The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. , 1999, Annual review of immunology.

[258]  A. Peters.  Just how big is the pulmonary granulocyte pool? , 1998, Clinical science.

[259]  D. Bainton,et al.  The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. , 1997, Blood.

[260]  J. Banchereau,et al.  Follicular dendritic cells and germinal centers. , 1996, International review of cytology.

[261]  J. Hogg,et al.  Leukocyte traffic in the lung. , 1995, Annual review of physiology.

[262]  Cees van Kooten,et al.  Activation os Human Dendritic Cells through CD40 Cross-I;nking By Christophe Caux, Catherine Massacrier, B6atrice Vanbervliet, , 1994 .