The UCSC Genome Browser Database: update 2009

The UCSC Genome Browser Database (GBD, http://genome.ucsc.edu) is a publicly available collection of genome assembly sequence data and integrated annotations for a large number of organisms, including extensive comparative-genomic resources. In the past year, 13 new genome assemblies have been added, including two important primate species, orangutan and marmoset, bringing the total to 46 assemblies for 24 different vertebrates and 39 assemblies for 22 different invertebrate animals. The GBD datasets may be viewed graphically with the UCSC Genome Browser, which uses a coordinate-based display system allowing users to juxtapose a wide variety of data. These data include all mRNAs from GenBank mapped to all organisms, RefSeq alignments, gene predictions, regulatory elements, gene expression data, repeats, SNPs and other variation data, as well as pairwise and multiple-genome alignments. A variety of other bioinformatics tools are also provided, including BLAT, the Table Browser, the Gene Sorter, the Proteome Browser, VisiGene and Genome Graphs.

[1]  Mary Shimoyama,et al.  The Rat Genome Database, update 2007—Easing the path from disease to data and back again , 2006, Nucleic Acids Res..

[2]  Joshua M. Korn,et al.  Mapping and sequencing of structural variation from eight human genomes , 2008, Nature.

[3]  David Haussler,et al.  The UCSC Genome Browser database: update 2010 , 2009, Nucleic Acids Res..

[4]  Judith A. Blake,et al.  The Mouse Genome Database (MGD): mouse biology and model systems , 2007, Nucleic Acids Res..

[5]  Tatiana Tatusova,et al.  NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins , 2004, Nucleic Acids Res..

[6]  D. Haussler,et al.  Evolution's cauldron: Duplication, deletion, and rearrangement in the mouse and human genomes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Terrence S. Furey,et al.  The UCSC Table Browser data retrieval tool , 2004, Nucleic Acids Res..

[8]  D. Haussler,et al.  Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. , 2005, Genome research.

[9]  Terrence S. Furey,et al.  The UCSC Genome Browser Database , 2003, Nucleic Acids Res..

[10]  W. J. Kent,et al.  BLAT--the BLAST-like alignment tool. , 2002, Genome research.

[11]  Mary Goldman,et al.  The UCSC Genome Browser database: update 2011 , 2010, Nucleic Acids Res..

[12]  Sue Povey,et al.  The HGNC Database in 2008: a resource for the human genome , 2007, Nucleic Acids Res..

[13]  Joshua L. Goodman,et al.  FlyBase: integration and improvements to query tools , 2007, Nucleic Acids Res..

[14]  M. Khoury,et al.  A navigator for human genome epidemiology , 2008, Nature Genetics.

[15]  D. Haussler,et al.  Human-mouse alignments with BLASTZ. , 2003, Genome research.

[16]  Michael D Waters,et al.  Database development in toxicogenomics: issues and efforts. , 2004, Environmental health perspectives.

[17]  Stijn van Dongen,et al.  miRBase: tools for microRNA genomics , 2007, Nucleic Acids Res..

[18]  David Haussler,et al.  The UCSC genome browser database: update 2007 , 2006, Nucleic Acids Res..

[19]  Elizabeth M. Smigielski,et al.  dbSNP: the NCBI database of genetic variation , 2001, Nucleic Acids Res..

[20]  L. Feuk,et al.  Detection of large-scale variation in the human genome , 2004, Nature Genetics.

[21]  R. Nielsen,et al.  Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages. , 2002, Molecular biology and evolution.

[22]  Songyan Liu,et al.  The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse , 2005, Nucleic Acids Res..

[23]  Obi L. Griffith,et al.  ORegAnno: an open-access community-driven resource for regulatory annotation , 2007, Nucleic Acids Res..

[24]  D. Haussler,et al.  Exploring relationships and mining data with the UCSC Gene Sorter. , 2005, Genome research.

[25]  D. Haussler,et al.  Aligning multiple genomic sequences with the threaded blockset aligner. , 2004, Genome research.

[26]  David Haussler,et al.  Comparative Genomics Search for Losses of Long-Established Genes on the Human Lineage , 2007, PLoS Comput. Biol..

[27]  Daniel J. Blankenberg,et al.  Galaxy: a platform for interactive large-scale genome analysis. , 2005, Genome research.

[28]  R. Nielsen,et al.  Patterns of Positive Selection in Six Mammalian Genomes , 2008, PLoS genetics.

[29]  G. Rubin,et al.  The BDGP Gene Disruption Project , 2004, Genetics.

[30]  Ryan D. Morin,et al.  The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). , 2004, Genome research.

[31]  Kara Dolinski,et al.  Gene Ontology annotations at SGD: new data sources and annotation methods , 2007, Nucleic Acids Res..

[32]  David Haussler,et al.  The UCSC Proteome Browser , 2004, Nucleic Acids Res..

[33]  Toshihiro Tanaka The International HapMap Project , 2003, Nature.

[34]  Paul T. Groth,et al.  The ENCODE (ENCyclopedia Of DNA Elements) Project , 2004, Science.

[35]  Andreas Prlic,et al.  Ensembl 2008 , 2007, Nucleic Acids Res..

[36]  Terrence S. Furey,et al.  The UCSC Genome Browser Database: update 2006 , 2005, Nucleic Acids Res..