Low Serum Insulinlike Growth Factor II Levels Correlate with High BMI in American Indian Adults

Insulinlike growth factor II (IGF‐II) regulates metabolism and growth. In humans, both positive and negative relationships have been reported between serum IGF‐II levels and obesity. This study assessed the relationship between serum IGF‐II levels and BMI and determined whether IGF‐II levels predict weight gain.

[1]  C. Bogardus,et al.  Assessing the Role of 98 Established Loci for Body Mass Index in American Indians , 2019, Obesity.

[2]  R. Hanson,et al.  Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an APOC3 Founder Mutation , 2017, Circulation. Cardiovascular genetics.

[3]  C. Bogardus,et al.  A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians , 2017, Diabetes.

[4]  C. Bogardus,et al.  Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex‐specific diabetes signals in GLIS3 and ZFAND3 , 2017, Diabetes/metabolism research and reviews.

[5]  Eric J Tchetgen Tchetgen,et al.  Methodological Challenges in Mendelian Randomization , 2014, Epidemiology.

[6]  S. Thompson,et al.  Use of allele scores as instrumental variables for Mendelian randomization , 2013, International journal of epidemiology.

[7]  B. Browning,et al.  A fast, powerful method for detecting identity by descent. , 2011, American journal of human genetics.

[8]  V. Moskvina,et al.  On multiple‐testing correction in genome‐wide association studies , 2008, Genetic epidemiology.

[9]  D. Dunger,et al.  Low circulating IGF-II concentrations predict weight gain and obesity in humans. , 2003, Diabetes.

[10]  M. Spitz,et al.  Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[11]  C. Bouchard,et al.  Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young men. , 2002, Metabolism: clinical and experimental.

[12]  L. Riste,et al.  Epidemiology of the insulin-like growth factor system in three ethnic groups. , 2001, American journal of epidemiology.

[13]  Tom R. Gaunt,et al.  Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. , 2001, Human molecular genetics.

[14]  S. Tilghman,et al.  Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity. , 2001, Human molecular genetics.

[15]  Antonio Musarò,et al.  Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle , 2001, Nature Genetics.

[16]  J. Holly The IGF-II enigma. , 1998, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[17]  L. Almasy,et al.  Multipoint quantitative-trait linkage analysis in general pedigrees. , 1998, American journal of human genetics.

[18]  S. Humphries,et al.  Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males , 1997, International Journal of Obesity.

[19]  M. Fantone,et al.  Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus , 1997, Diabetes Care.

[20]  H. Orskov,et al.  Free insulin-like growth factors in human obesity. , 1995, Metabolism: clinical and experimental.

[21]  D. Clemmons,et al.  Insulin-like growth factors and their binding proteins: biological actions. , 1995, Endocrine reviews.

[22]  I. Robinson,et al.  High plasma insulin-like growth factor-II and low lipid content in transgenic mice: measurements of lipid metabolism. , 1994, The Journal of endocrinology.

[23]  G. Tannenbaum,et al.  Centrally administered insulin-like growth factor II fails to alter pulsatile growth hormone secretion or food intake. , 1992, Neuroendocrinology.

[24]  P. Bennett,et al.  Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. , 1990, Diabetes/metabolism reviews.

[25]  J. Flier,et al.  Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. , 1989, Molecular endocrinology.

[26]  D. Dorsa,et al.  Insulin and insulin-like growth factors in the CNS , 1988, Trends in Neurosciences.

[27]  W. Daughaday,et al.  Evidence for the role of insulin-like growth factor II (IGF-II) in the control of food intake , 1987, Physiology & Behavior.