Islands of linkage disequilibrium

A detailed knowledge of patterns of linkage disequilibrium in human populations is widely seen as a prerequisite for effective population-based disease gene mapping. New data suggest that linkage disequilibrium is highly structured into discrete blocks of sequence separated by hot spots of recombination.

[1]  E. Boerwinkle,et al.  Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. , 1998, American journal of human genetics.

[2]  P. Zaphiropoulos,et al.  The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. , 2000, Gene.

[3]  A. Paulussen,et al.  Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans. , 2000, Pharmacogenetics.

[4]  E. Boerwinkle,et al.  Recombinational and mutational hotspots within the human lipoprotein lipase gene. , 2000, American journal of human genetics.

[5]  Ann Daly,et al.  Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression , 2001, Nature Genetics.

[6]  A. Jeffreys,et al.  Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex , 2001, Nature Genetics.

[7]  M. Daly,et al.  High-resolution haplotype structure in the human genome , 2001, Nature Genetics.

[8]  Frank Dudbridge,et al.  Haplotype tagging for the identification of common disease genes , 2001, Nature Genetics.

[9]  Pardis C Sabeti,et al.  Linkage disequilibrium in the human genome , 2001, Nature.

[10]  J. Stephens,et al.  Haplotype Variation and Linkage Disequilibrium in 313 Human Genes , 2001, Science.

[11]  Sinead B. O'Leary,et al.  Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease , 2001, Nature Genetics.