A Robust Multilevel DWT Densely Network for Cardiovascular Disease Classification

Cardiovascular disease is the leading cause of death worldwide. Immediate and accurate diagnoses of cardiovascular disease are essential for saving lives. Although most of the previously reported works have tried to classify heartbeats accurately based on the intra-patient paradigm, they suffer from category imbalance issues since abnormal heartbeats appear much less regularly than normal heartbeats. Furthermore, most existing methods rely on data preprocessing steps, such as noise removal and R-peak location. In this study, we present a robust classification system using a multilevel discrete wavelet transform densely network (MDD-Net) for the accurate detection of normal, coronary artery disease (CAD), myocardial infarction (MI) and congestive heart failure (CHF). First, the raw ECG signals from different databases are divided into same-size segments using an original adaptive sample frequency segmentation algorithm (ASFS). Then, the fusion features are extracted from the MDD-Net to achieve great classification performance. We evaluated the proposed method considering the intra-patient and inter-patient paradigms. The average accuracy, positive predictive value, sensitivity and specificity were 99.74%, 99.09%, 98.67% and 99.83%, respectively, under the intra-patient paradigm, and 96.92%, 92.17%, 89.18% and 97.77%, respectively, under the inter-patient paradigm. Moreover, the experimental results demonstrate that our model is robust to noise and class imbalance issues.

[1]  Christopher Cannon,et al.  The ECG: A Two-Step Approach to Diagnosis , 2003 .

[2]  U. Rajendra Acharya,et al.  A deep convolutional neural network model to classify heartbeats , 2017, Comput. Biol. Medicine.

[3]  Ramesh Kumar Sunkaria,et al.  Inferior myocardial infarction detection using stationary wavelet transform and machine learning approach , 2017, Signal, Image and Video Processing.

[4]  Li Shi,et al.  Automated interpretable detection of myocardial infarction fusing energy entropy and morphological features , 2019, Comput. Methods Programs Biomed..

[5]  Hui Han,et al.  Borderline-SMOTE: A New Over-Sampling Method in Imbalanced Data Sets Learning , 2005, ICIC.

[6]  Mohammad Bagher Shamsollahi,et al.  Multiadaptive Bionic Wavelet Transform: Application to ECG Denoising and Baseline Wandering Reduction , 2007, EURASIP J. Adv. Signal Process..

[7]  U. Rajendra Acharya,et al.  A novel automated diagnostic system for classification of myocardial infarction ECG signals using an optimal biorthogonal filter bank , 2018, Comput. Biol. Medicine.

[8]  U. Rajendra Acharya,et al.  Deep convolutional neural network for the automated diagnosis of congestive heart failure using ECG signals , 2018, Applied Intelligence.

[9]  Samarendra Dandapat,et al.  Third-order tensor based analysis of multilead ECG for classification of myocardial infarction , 2017, Biomed. Signal Process. Control..

[10]  J. Willerson,et al.  The role of coronary artery lesions in ischemic heart disease: insights from recent clinicopathologic, coronary arteriographic, and experimental studies. , 1987, Human pathology.

[11]  U. Rajendra Acharya,et al.  Automated characterization of coronary artery disease, myocardial infarction, and congestive heart failure using contourlet and shearlet transforms of electrocardiogram signal , 2017, Knowl. Based Syst..

[12]  John E Madias,et al.  ECG changes in response to diuresis in an ambulatory patient with congestive heart failure. , 2006, Congestive heart failure.

[13]  Ingrid Daubechies,et al.  The wavelet transform, time-frequency localization and signal analysis , 1990, IEEE Trans. Inf. Theory.

[14]  Heasoo Hwang,et al.  A robust deep convolutional neural network with batch-weighted loss for heartbeat classification , 2019, Expert Syst. Appl..

[15]  Kilian Q. Weinberger,et al.  Densely Connected Convolutional Networks , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[16]  Celia Shahnaz,et al.  Detection of inferior myocardial infarction using shallow convolutional neural networks , 2017, 2017 IEEE Region 10 Humanitarian Technology Conference (R10-HTC).

[17]  U. Rajendra Acharya,et al.  Automated characterization and classification of coronary artery disease and myocardial infarction by decomposition of ECG signals: A comparative study , 2017, Inf. Sci..

[18]  U. Rajendra Acharya,et al.  Automated diagnosis of congestive heart failure using dual tree complex wavelet transform and statistical features extracted from 2 s of ECG signals , 2017, Comput. Biol. Medicine.

[19]  U. Rajendra Acharya,et al.  Application of deep convolutional neural network for automated detection of myocardial infarction using ECG signals , 2017, Inf. Sci..

[20]  Jian Sun,et al.  Deep Residual Learning for Image Recognition , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[21]  U. Rajendra Acharya,et al.  Characterization of coronary artery disease using flexible analytic wavelet transform applied on ECG signals , 2017, Biomed. Signal Process. Control..

[22]  A. Goldberger Clinical Electrocardiography: A Simplified Approach , 1977 .

[23]  Philip de Chazal,et al.  Automatic classification of heartbeats using ECG morphology and heartbeat interval features , 2004, IEEE Transactions on Biomedical Engineering.

[24]  Nitesh V. Chawla,et al.  SMOTE: Synthetic Minority Over-sampling Technique , 2002, J. Artif. Intell. Res..

[25]  U. Rajendra Acharya,et al.  Automated detection and localization of myocardial infarction using electrocardiogram: a comparative study of different leads , 2016, Knowl. Based Syst..

[26]  U. Rajendra Acharya,et al.  Classification of myocardial infarction with multi-lead ECG signals and deep CNN , 2019, Pattern Recognit. Lett..

[27]  U. Rajendra Acharya,et al.  Application of higher-order spectra for the characterization of Coronary artery disease using electrocardiogram signals , 2017, Biomed. Signal Process. Control..

[28]  Huifang Huang,et al.  A new hierarchical method for inter-patient heartbeat classification using random projections and RR intervals , 2014, BioMedical Engineering OnLine.

[29]  Paul S Addison,et al.  Wavelet transforms and the ECG: a review , 2005, Physiological measurement.

[30]  Sergey Ioffe,et al.  Rethinking the Inception Architecture for Computer Vision , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[31]  Abdulhamit Subasi,et al.  Detection of congestive heart failures using C4.5 Decision Tree , 2013, SOCO 2013.

[32]  Andrew Zisserman,et al.  Very Deep Convolutional Networks for Large-Scale Image Recognition , 2014, ICLR.

[33]  Jeffrey M. Hausdorff,et al.  Physionet: Components of a New Research Resource for Complex Physiologic Signals". Circu-lation Vol , 2000 .

[34]  F. Sebening,et al.  [Coronary artery disease]. , 1980, Verhandlungen der Deutschen Gesellschaft fur Herz- und Kreislaufforschung.

[35]  Radford M. Neal Pattern Recognition and Machine Learning , 2007, Technometrics.

[36]  U. Rajendra Acharya,et al.  Characterization of Cardiovascular Diseases Using Wavelet Packet Decomposition and Nonlinear Measures of Electrocardiogram Signal , 2017, IEA/AIE.

[37]  Ross B. Girshick,et al.  Focal Loss for Dense Object Detection , 2017, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[38]  David Menotti,et al.  How the choice of samples for building arrhythmia classifiers impact their performances , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[39]  Dumitru Erhan,et al.  Going deeper with convolutions , 2014, 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).