Parecoxib, propacetamol, and their combination for analgesia after total hip arthroplasty: a randomized non‐inferiority trial

This study assessed non‐inferiority of parecoxib vs. combination parecoxib+propacetamol and compared the opioid‐sparing effects of parecoxib, propacetamol, and parecoxib+propacetamol vs. placebo after total hip arthroplasty.

[1]  H. Pommergaard,et al.  Adverse effects of perioperative paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review , 2014, Acta anaesthesiologica Scandinavica.

[2]  J B Dahl,et al.  Post‐operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review , 2014, Acta anaesthesiologica Scandinavica.

[3]  J. Pergolizzi,et al.  Intravenous acetaminophen reduces postoperative nausea and vomiting: A systematic review and meta-analysis , 2013, PAIN®.

[4]  F. Haddad,et al.  Peri-operative interventions producing better functional outcomes and enhanced recovery following total hip and knee arthroplasty: an evidence-based review , 2013, BMC Medicine.

[5]  S. Abdulla,et al.  Efficacy of three IV non-opioid-analgesics on opioid consumption for postoperative pain relief after total thyroidectomy: a randomised, double-blind trial. , 2012, Middle East journal of anaesthesiology.

[6]  H. McQuay,et al.  Mean analgesic consumption is inappropriate for testing analgesic efficacy in post-operative pain: analysis and alternative suggestion , 2011, European journal of anaesthesiology.

[7]  N. Woolacott,et al.  Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. , 2011, British journal of anaesthesia.

[8]  B. Ellger,et al.  Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minor-to-intermediate surgery: a randomised, double-blind trial , 2011, European journal of anaesthesiology.

[9]  A. Khattab,et al.  Combined parecoxib and I.V. paracetamol provides additional analgesic effect with better postoperative satisfaction in patients undergoing anterior cruciate ligament reconstruction , 2011, Saudi journal of anaesthesia.

[10]  C. Arndt,et al.  Postoperative analgesia with parecoxib, acetaminophen, and the combination of both: a randomized, double-blind, placebo-controlled trial in patients undergoing thyroid surgery. , 2010, British journal of anaesthesia.

[11]  H. Kehlet,et al.  Fast-track hip and knee replacement — what are the issues? , 2010, Acta orthopaedica.

[12]  A. Merry,et al.  Combining Paracetamol (Acetaminophen) with Nonsteroidal Antiinflammatory Drugs: A Qualitative Systematic Review of Analgesic Efficacy for Acute Postoperative Pain , 2010, Anesthesia and analgesia.

[13]  D. Revicki,et al.  Reduction in Opioid-Related Adverse Events and Improvement in Function with Parecoxib followed by Valdecoxib Treatment after Non-Cardiac Surgery , 2009, Clinical drug investigation.

[14]  E. Kalso,et al.  Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomy , 2008, Acta anaesthesiologica Scandinavica.

[15]  S. Kreuer,et al.  The Efficacy of the Non-Opioid Analgesics Parecoxib, Paracetamol and Metamizol for Postoperative Pain Relief After Lumbar Microdiscectomy , 2006, Anesthesia and analgesia.

[16]  N. Nussmeier,et al.  Safety and Efficacy of the Cyclooxygenase-2 Inhibitors Parecoxib and Valdecoxib after Noncardiac Surgery , 2006, Anesthesiology.

[17]  M. Tramèr,et al.  Does Multimodal Analgesia with Acetaminophen, Nonsteroidal Antiinflammatory Drugs, or Selective Cyclooxygenase-2 Inhibitors and Patient-controlled Analgesia Morphine Offer Advantages over Morphine Alone?: Meta-analyses of Randomized Trials , 2005, Anesthesiology.

[18]  P. White The Changing Role of Non-Opioid Analgesic Techniques in the Management of Postoperative Pain , 2005, Anesthesia and analgesia.

[19]  A. Basbaum,et al.  Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System* , 2005, Journal of Biological Chemistry.

[20]  P. Zufferey,et al.  Effects of Nonsteroidal Antiinflammatory Drugs on Patient-controlled Analgesia Morphine Side Effects: Meta-analysis of Randomized Controlled Trials , 2005, Anesthesiology.

[21]  M. Beaussier,et al.  A Randomized, Double-Blind Comparison Between Parecoxib Sodium and Propacetamol for Parenteral Postoperative Analgesia After Inguinal Hernia Repair in Adult Patients , 2005, Anesthesia and analgesia.

[22]  F. Bonnet,et al.  Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. , 2005, British journal of anaesthesia.

[23]  O. Mathiesen,et al.  Reduction of opioid‐related adverse events using opioid‐sparing analgesia with COX‐2 inhibitors lacks documentation: A systematic review , 2005, Acta anaesthesiologica Scandinavica.

[24]  D. Hanna,et al.  Reliability and Validity of the Perioperative Opioid-Related Symptom Distress Scale , 2004, Anesthesia and analgesia.

[25]  C. Cleeland,et al.  The Utility and Validity of the Modified Brief Pain Inventory in a Multiple-Dose Postoperative Analgesic Trial , 2004, The Clinical journal of pain.

[26]  F. Chung,et al.  Dose-response relationship between opioid use and adverse effects after ambulatory surgery. , 2004, Journal of pain and symptom management.

[27]  D. Fegley,et al.  Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[28]  G. Joshi,et al.  Effective Treatment of Laparoscopic Cholecystectomy Pain with Intravenous Followed by Oral COX-2 Specific Inhibitor , 2004, Anesthesia and analgesia.

[29]  R. Hubbard,et al.  Parecoxib Sodium, a Parenteral Cyclooxygenase 2 Selective Inhibitor, Improves Morphine Analgesia and Is Opioid-sparing following Total Hip Arthroplasty , 2003, Anesthesiology.

[30]  P. Coriat,et al.  Adjunctive analgesia with intravenous propacetamol does not reduce morphine-related adverse effects. , 2003, British journal of anaesthesia.

[31]  R. Hubbard,et al.  Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia. , 2003, British journal of anaesthesia.

[32]  M. Kuss,et al.  Efficacy and Safety of Intravenous Parecoxib Sodium in Relieving Acute Postoperative Pain following Gynecologic Laparotomy Surgery , 2002, Anesthesiology.

[33]  P. White,et al.  Effect of Parecoxib, A Novel Intravenous Cyclooxygenase Type-2 Inhibitor, on the Postoperative Opioid Requirement and Quality of Pain Control , 2002, Anesthesiology.

[34]  J. Dahl,et al.  Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia. , 2002, British journal of anaesthesia.

[35]  H. Kehlet,et al.  Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. , 2002, British journal of anaesthesia.

[36]  F. Camu,et al.  Valdecoxib, a COX-2–Specific Inhibitor, Is an Efficacious, Opioid-Sparing Analgesic in Patients Undergoing Hip Arthroplasty , 2002, American journal of therapeutics.

[37]  R. Botting,et al.  Mechanism of action of acetaminophen: is there a cyclooxygenase 3? , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[38]  P. Coriat,et al.  Randomised, placebo‐controlled study of the postoperative analgesic effects of ketoprofen after spinal fusion surgery , 2000, Acta anaesthesiologica Scandinavica.

[39]  K. Samii,et al.  Postoperative analgesia withiv propacetamol and ketoprofen combination after disc surgery , 1997, Canadian journal of anaesthesia = Journal canadien d'anesthesie.