Recognition of Uncharged Polyamide-Linked Nucleic Acid Analogs by DNA Polymerases and Reverse Transcriptases

Department of ChemistrySwiss Federal Institute of TechnologyUniVersita¨tstrasse 16CH-8092 Zu¨rich, SwitzerlandHoechst AG, HMR Pharma Research G838D-65926 Frankfurt, GermanyReceiVed October 28, 1996Polyamide-linked nucleic acid analogs (PNAs) are DNAmimics in which the deoxyribose phosphate backbone isreplaced by uncharged N-(2-aminoethyl)glycine units.