Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease

[1]  L. Vives,et al.  Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells , 2008, Proceedings of the National Academy of Sciences.

[2]  N. Blin,et al.  The CpG Island Methylator Phenotype Correlates with Long-Range Epigenetic Silencing in Colorectal Cancer , 2008, Molecular Cancer Research.

[3]  Bela Molnar,et al.  DNA methylation biomarkers for blood-based colorectal cancer screening. , 2008, Clinical chemistry.

[4]  Dao-rong Wang,et al.  Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening. , 2008, World journal of gastroenterology.

[5]  L. Hesson,et al.  Evaluation of the 3p21.3 tumour-suppressor gene cluster , 2007, Oncogene.

[6]  S. Clark,et al.  Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. , 2007, Cancer research.

[7]  Y. Kodera,et al.  P16 methylation in serum as a potential marker for the malignancy of colorectal carcinoma. , 2007, Anticancer research.

[8]  X. Solé,et al.  Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. , 2007, International journal of oncology.

[9]  M. Esteller.  Epigenetic gene silencing in cancer: the DNA hypermethylome. , 2007, Human molecular genetics.

[10]  Zhaohui Huang,et al.  Hypermethylation of SFRP2 as a Potential Marker for Stool-Based Detection of Colorectal Cancer and Precancerous Lesions , 2007, Digestive Diseases and Sciences.

[11]  M. Esteller.  Cancer epigenomics: DNA methylomes and histone-modification maps , 2007, Nature Reviews Genetics.

[12]  A. Riggs,et al.  Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay , 2007, Proceedings of the National Academy of Sciences.

[13]  H. Müller,et al.  DNA Methylation in Colorectal cancer—Impact on Screening and Therapy Monitoring Modalities? , 2007, Disease markers.

[14]  Fan Yang,et al.  Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. , 2007, World journal of gastroenterology.

[15]  D. Pinkel,et al.  Regional copy number–independent deregulation of transcription in cancer , 2006, Nature Genetics.

[16]  Clare Stirzaker,et al.  Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band , 2006, Nature Genetics.

[17]  A. Yaniv,et al.  Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway. , 2006, Molecular biology of the cell.

[18]  S. Baylin,et al.  DNA methylation and gene silencing in cancer , 2005, Nature Clinical Practice Oncology.

[19]  F. Chan,et al.  Quantitative Detection of Promoter Hypermethylation in Multiple Genes in the Serum of Patients with Colorectal Cancer , 2005, The American Journal of Gastroenterology.

[20]  L. Myeroff,et al.  Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. , 2005, Journal of the National Cancer Institute.

[21]  G. Rennert,et al.  Fecal DNA biomarkers for the detection of colorectal neoplasia: attractive, but is it feasible? , 2005, Journal of the National Cancer Institute.

[22]  Martha R. Stampfer,et al.  Chromatin Inactivation Precedes De Novo DNA Methylation during the Progressive Epigenetic Silencing of the RASSF1A Promoter , 2005, Molecular and Cellular Biology.

[23]  G. Capellá.  Is fecal DNA testing superior to fecal occult-blood testing for colorectal cancer screening? , 2005, Nature Clinical Practice Oncology.

[24]  Gabriel Capellà,et al.  Genomic determinants of prognosis in colorectal cancer. , 2005, Cancer letters.

[25]  R. Lamerz,et al.  Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[26]  M. Washington,et al.  Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[27]  M. Paz,et al.  Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. , 2005, Human molecular genetics.

[28]  F. Chan,et al.  Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study. , 2004, Clinical chemistry.

[29]  S. J. Mills,et al.  Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[30]  S. Clark,et al.  Transcriptional Gene Silencing Promotes DNA Hypermethylation through a Sequential Change in Chromatin Modifications in Cancer Cells , 2004, Cancer Research.

[31]  A. Feinberg,et al.  The history of cancer epigenetics , 2004, Nature Reviews Cancer.

[32]  G. Felsenfeld,et al.  Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9 , 2004, The EMBO journal.

[33]  Jing Yi,et al.  Detection of aberrant p16 methylation in the serum of colorectal cancer patients. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[34]  K. Kinzler,et al.  Detection of APC mutations in fecal DNA from patients with colorectal tumors. , 2002, The New England journal of medicine.

[35]  S. Goodman,et al.  Detecting colorectal cancer in stool with the use of multiple genetic targets. , 2001, Journal of the National Cancer Institute.

[36]  V. Moreno,et al.  Standardized approach for microsatellite instability detection in colorectal carcinomas. , 2000, Journal of the National Cancer Institute.

[37]  S. Clark,et al.  Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. , 1999, Cancer research.

[38]  J. Herman,et al.  CpG island methylator phenotype in colorectal cancer. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[39]  G. Capellá,et al.  Improved detection of K-ras codon 12 mutations in fecal exfoliated cells. , 1999, Laboratory investigation; a journal of technical methods and pathology.

[40]  G. Capellá,et al.  K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  D. Ahlquist.  Stool-based DNA tests for colorectal cancer: clinical potential and early results. , 2002, Reviews in gastroenterological disorders.